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Signaling by FGFR1 amplification mutants
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authored
[InstanceEdit:2105031] Rothfels, K, 2012年02月09日
compartment
[Compartment:70101] cytosol
[Compartment:984] extracellular region
[Compartment:876] plasma membrane
[Compartment:7660] nucleoplasm
created
[InstanceEdit:1839119] Rothfels, K, 2011年10月27日
crossReference
[DatabaseIdentifier:12757882] BioModels Database:BIOMD0000000664
[DatabaseIdentifier:11944892] Mondo:0004992
[DatabaseIdentifier:12757884] BioModels Database:BIOMD0000000883
dbId
1839120
disease
[Disease:1500689] cancer
displayName
Signaling by FGFR1 amplification mutants
edited
[InstanceEdit:2252592] Rothfels, K, 2012年05月16日
eventOf
[Pathway:R-HSA-1839124] FGFR1 mutant receptor activation - Homo sapiens
hasDiagram
false
hasEHLD
false
hasEvent
[Reaction:R-HSA-1982065] Ligand-independent dimerization of overexpressed FGFR1b - Homo sapiens
[Reaction:R-HSA-1982066] Ligand-independent phosphorylation of overexpressed FGFR1 - Homo sapiens
[Reaction:R-HSA-5654544] Ligand-independent dimerization of overexpressed FGFR1c - Homo sapiens
[Reaction:R-HSA-5654545] Ligand-independent phosphorylation of overexpressed FGFR1c - Homo sapiens
[Reaction:R-HSA-2023462] Tyrosine kinase inhibitors bind and inhibit overexpressed FGFR1 dimers - Homo sapiens
isInDisease
true
isInferred
false
lastUpdatedDate
2015年03月23日
literatureReference
[LiteratureReference:1614274] Targeting mutant fibroblast growth factor receptors in cancer
[LiteratureReference:1307938] Fibroblast growth factor signalling: from development to cancer
[LiteratureReference:1982028] Frequent and focal FGFR1 amplification associates with therapeutically tractable FGFR1 dependency in squamous cell lung cancer
[LiteratureReference:1982030] Inhibitor-Sensitive FGFR1 Amplification in Human Non-Small Cell Lung Cancer
[LiteratureReference:1986648] Genomic imbalances in rhabdomyosarcoma cell lines affect expression of genes frequently altered in primary tumors: an approach to identify candidate genes involved in tumor development
[LiteratureReference:2011995] FGFR1 amplification drives endocrine therapy resistance and is a therapeutic target in breast cancer
[LiteratureReference:2012016] Recurrent FGFR1 amplification and high FGFR1 protein expression in oral squamous cell carcinoma (OSCC)
[LiteratureReference:2012006] High-resolution single nucleotide polymorphism array analysis of epithelial ovarian cancer reveals numerous microdeletions and amplifications
[LiteratureReference:2012008] High-throughput tissue microarray analysis of 3p25 (RAF1) and 8p12 (FGFR1) copy number alterations in urinary bladder cancer
[LiteratureReference:2012003] Gene amplifications associated with the development of hormone-resistant prostate cancer
[LiteratureReference:2012011] Inducible FGFR-1 activation leads to irreversible prostate adenocarcinoma and an epithelial-to-mesenchymal transition
[LiteratureReference:2012018] SOX2 is an amplified lineage-survival oncogene in lung and esophageal squamous cell carcinomas
[LiteratureReference:2011992] Characterization of the recurrent 8p11-12 amplicon identifies PPAPDC1B, a phosphatase protein, as a new therapeutic target in breast cancer
[LiteratureReference:2012004] Genomic and expression analysis of the 8p11-12 amplicon in human breast cancer cell lines
[LiteratureReference:2011999] Fibroblast growth factor (FGF) and FGF receptor-mediated autocrine signaling in non-small-cell lung cancer cells
[LiteratureReference:2011997] FGFR1 emerges as a potential therapeutic target for lobular breast carcinomas
[LiteratureReference:2012000] Gene amplification profiling of esophageal squamous cell carcinomas by DNA array CGH
maxDepth
2
modified
[InstanceEdit:12757879] Weiser, Joel, 2025年08月05日
name
Signaling by FGFR1 amplification mutants
releaseDate
2012年06月12日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:2248845] Ezzat, S, 2012年05月15日
schemaClass
Pathway
species
[Species:48887] Homo sapiens
stId
R-HSA-1839120
summation
[Summation:2012091] Amplification or activation of FGFR1 has been reported in l...
updateTrackers
[UpdateTracker:9785027] Update Tracker - [Pathway:1839120] Signaling by FGFR1 amplification mutants - v52:[addHasEvent, updateContainedRLE]
Referrals
(updatedInstance)
[UpdateTracker:9785027] Update Tracker - [Pathway:1839120] Signaling by FGFR1 amplification mutants - v52:[addHasEvent, updateContainedRLE]
(hasEvent)
[Pathway:R-HSA-1839124] FGFR1 mutant receptor activation
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