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Schema
>
Reaction
>
Entries
PAPSS1,2 transfer SO4(2-) group to ATP to form APS
Show undefined attributes
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catalystActivity
[CatalystActivity:174381] sulfate adenylyltransferase (ATP) activity of PAPSS1,2 [cytosol]
category
transition
compartment
[Compartment:70101] cytosol
created
[InstanceEdit:174378] Jassal, Bijay, 2006年02月17日
crossReference
[DatabaseIdentifier:12610843] Rhea:18134
[DatabaseIdentifier:9941489] RHEA:18134
dbId
174392
displayName
PAPSS1,2 transfer SO4(2-) group to ATP to form APS
eventOf
[Pathway:R-HSA-174362] Transport and metabolism of PAPS - Homo sapiens
followingEvent
[Reaction:R-HSA-174389] PAPSS1,2 transfer PO4(2-) group from ATP to APS to form PAPS - Homo sapiens
[Reaction:R-HSA-71732] PPA1 hydrolyzes pyrophosphate to orthophosphate - Homo sapiens
goBiologicalProcess
[GO_BiologicalProcess:80800] 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process
input
[SimpleEntity:R-ALL-113592] ATP [cytosol]
[SimpleEntity:R-ALL-70106] H+ [cytosol]
[SimpleEntity:R-ALL-174375] SO4(2-) [cytosol]
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:176622] Sulfation in high endothelial venules: cloning and expression of the human PAPS synthetase
[LiteratureReference:176653] Mutations in orthologous genes in human spondyloepimetaphyseal dysplasia and the brachymorphic mouse
[LiteratureReference:176713] Molecular cloning, expression, and characterization of human bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase and its functional domains
maxDepth
1
modified
[InstanceEdit:11033291] Weiser, Joel, 2025年08月28日
name
PAPSS1,2 transfer SO4(2-) group to ATP to form APS
ATP + sulfate => adenylyl sulfate (APS) + pyrophosphate
Activation of inorganic sulfate forms APS
orthologousEvent
[Reaction:R-MMU-174392] PAPSS1,2 transfer SO4(2-) group to ATP to form APS - Mus musculus
[Reaction:R-SCE-174392] PAPSS1,2 transfer SO4(2-) group to ATP to form APS - Saccharomyces cerevisiae
[Reaction:R-SPO-174392] PAPSS1,2 transfer SO4(2-) group to ATP to form APS - Schizosaccharomyces pombe
[Reaction:R-CEL-174392] PAPSS1,2 transfer SO4(2-) group to ATP to form APS - Caenorhabditis elegans
[Reaction:R-DME-174392] PAPSS1,2 transfer SO4(2-) group to ATP to form APS - Drosophila melanogaster
[Reaction:R-GGA-174392] PAPSS1,2 transfer SO4(2-) group to ATP to form APS - Gallus gallus
[Reaction:R-XTR-174392] PAPSS1,2 transfer SO4(2-) group to ATP to form APS - Xenopus tropicalis
[Reaction:R-DRE-174392] PAPSS1,2 transfer SO4(2-) group to ATP to form APS - Danio rerio
[Reaction:R-SSC-174392] PAPSS1,2 transfer SO4(2-) group to ATP to form APS - Sus scrofa
[Reaction:R-BTA-174392] PAPSS1,2 transfer SO4(2-) group to ATP to form APS - Bos taurus
[Reaction:R-CFA-174392] PAPSS1,2 transfer SO4(2-) group to ATP to form APS - Canis familiaris
[Reaction:R-RNO-174392] PAPSS1,2 transfer SO4(2-) group to ATP to form APS - Rattus norvegicus
output
[SimpleEntity:R-ALL-174370] APS [cytosol]
[SimpleEntity:R-ALL-111294] PPi [cytosol]
precedingEvent
[Reaction:R-HSA-427555] SLC26A1,2 cotransport SO4(2-), anion from extracellular region to cytosol - Homo sapiens
[Reaction:R-HSA-9941470] SLC26A11 imports SO4(2-) and H+ into cytosol - Homo sapiens
releaseDate
2005年04月11日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:9774232] Hill, David P, 2022年05月19日
revised
[InstanceEdit:9774231] D'Eustachio, Peter, 2022年05月19日
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-174392
summation
[Summation:176662] In the first step of PAPS biosynthesis, ATP and sulfate reac...
updateTrackers
[UpdateTracker:9846990] Update Tracker - [Reaction:174392] PAPSS1,2 transfer SO4(2-) group to ATP to form APS - v82:[addInput]
[UpdateTracker:9786165] Update Tracker - [Reaction:174392] PAPSS1,2 transfer SO4(2-) group to ATP to form APS - v50:[modifyText]
[UpdateTracker:9787312] Update Tracker - [Reaction:174392] PAPSS1,2 transfer SO4(2-) group to ATP to form APS - v45:[modifyText]
Referrals
(updatedInstance)
[UpdateTracker:9846990] Update Tracker - [Reaction:174392] PAPSS1,2 transfer SO4(2-) group to ATP to form APS - v82:[addInput]
[UpdateTracker:9786165] Update Tracker - [Reaction:174392] PAPSS1,2 transfer SO4(2-) group to ATP to form APS - v50:[modifyText]
[UpdateTracker:9787312] Update Tracker - [Reaction:174392] PAPSS1,2 transfer SO4(2-) group to ATP to form APS - v45:[modifyText]
(normalReaction)
[FailedReaction:R-HSA-3560794] Defective PAPSS2 does not transfer SO4(2-) group to ATP to form APS
(hasEvent)
[Pathway:R-HSA-174362] Transport and metabolism of PAPS
(precedingEvent)
[Reaction:R-HSA-174389] PAPSS1,2 transfer PO4(2-) group from ATP to APS to form PAPS
[Reaction:R-HSA-71732] PPA1 hydrolyzes pyrophosphate to orthophosphate
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