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Schema
>
Reaction
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Entries
PAPSS1,2 transfer PO4(2-) group from ATP to APS to form PAPS
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catalystActivity
[CatalystActivity:174366] adenylylsulfate kinase activity of PAPSS1,2 [cytosol]
category
transition
compartment
[Compartment:70101] cytosol
created
[InstanceEdit:174378] Jassal, Bijay, 2006年02月17日
crossReference
[DatabaseIdentifier:9941469] RHEA:24153
[DatabaseIdentifier:12610974] Rhea:24153
dbId
174389
displayName
PAPSS1,2 transfer PO4(2-) group from ATP to APS to form PAPS
eventOf
[Pathway:R-HSA-174362] Transport and metabolism of PAPS - Homo sapiens
followingEvent
[Reaction:R-HSA-741449] SLC35B2,3 exchange cytosolic PAPS with Golgi PAP - Homo sapiens
[Reaction:R-HSA-158849] Phenol can form a sulfate conjugate - Homo sapiens
[Reaction:R-HSA-176609] cholesterol + PAPS => cholesterol sulfate + PAP - Homo sapiens
[Reaction:R-HSA-176646] p-nitrophenol + PAPS => p-nitrophenol sulfate + PAP - Homo sapiens
[Reaction:R-HSA-158468] SULT1A1 dimer sulfonates PARA to PARA-SO4 - Homo sapiens
[Reaction:R-HSA-176517] SULTs transfer (SO4)2- group to PREG - Homo sapiens
[Reaction:R-HSA-176585] 3,5,3'-triiodothyronine + PAPS => 3,5,3'-triiodothyronine 4-sulfate + PAP - Homo sapiens
[Reaction:R-HSA-176521] beta-estradiol + PAPS => beta-estradiol 3-sulfate + PAP - Homo sapiens
[Reaction:R-HSA-176494] SULTs transfer (SO4)2- group to 27HCHOL - Homo sapiens
[Reaction:R-HSA-158860] SULT1A1 dimer sulfonates NHABP - Homo sapiens
[Reaction:R-HSA-176588] lithocholate + PAPS => lithocholate sulfate + PAP - Homo sapiens
[Reaction:R-HSA-176631] dehydroepiandrosterone (DHEA) + PAPS => DHEA sulfate + PAP - Homo sapiens
[Reaction:R-HSA-176474] 3,3'-diiodothyronine + PAPS => 3,3'-diiodothyronine 4-sulfate + PAP - Homo sapiens
[Reaction:R-HSA-176664] estrone + PAPS => estrone 3-sulfate + PAP - Homo sapiens
[Reaction:R-HSA-159358] SULT1A3,4 dimers sulfate DA to DAOS - Homo sapiens
[Reaction:R-HSA-176604] taurolithocholate + PAPS => taurolithocholate sulfate + PAP - Homo sapiens
[Reaction:R-HSA-176669] N-hydroxy-2-acetylaminofluorene + PAPS => 2-acetylaminofluorene-N-sulfate + PAP - Homo sapiens
goBiologicalProcess
[GO_BiologicalProcess:80800] 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process
input
[SimpleEntity:R-ALL-174370] APS [cytosol]
[SimpleEntity:R-ALL-113592] ATP [cytosol]
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:176653] Mutations in orthologous genes in human spondyloepimetaphyseal dysplasia and the brachymorphic mouse
[LiteratureReference:176622] Sulfation in high endothelial venules: cloning and expression of the human PAPS synthetase
[LiteratureReference:176713] Molecular cloning, expression, and characterization of human bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase and its functional domains
maxDepth
1
modified
[InstanceEdit:11033291] Weiser, Joel, 2025年08月28日
name
PAPSS1,2 transfer PO4(2-) group from ATP to APS to form PAPS
adenylyl sulfate (APS) + ATP => PAPS + ADP
APS reacts with another ATP molecule to form PAPS
orthologousEvent
[Reaction:R-MMU-174389] PAPSS1,2 transfer PO4(2-) group from ATP to APS to form PAPS - Mus musculus
[Reaction:R-CFA-174389] PAPSS1,2 transfer PO4(2-) group from ATP to APS to form PAPS - Canis familiaris
[Reaction:R-BTA-174389] PAPSS1,2 transfer PO4(2-) group from ATP to APS to form PAPS - Bos taurus
[Reaction:R-SSC-174389] PAPSS1,2 transfer PO4(2-) group from ATP to APS to form PAPS - Sus scrofa
[Reaction:R-DRE-174389] PAPSS1,2 transfer PO4(2-) group from ATP to APS to form PAPS - Danio rerio
[Reaction:R-XTR-174389] PAPSS1,2 transfer PO4(2-) group from ATP to APS to form PAPS - Xenopus tropicalis
[Reaction:R-GGA-174389] PAPSS1,2 transfer PO4(2-) group from ATP to APS to form PAPS - Gallus gallus
[Reaction:R-DME-174389] PAPSS1,2 transfer PO4(2-) group from ATP to APS to form PAPS - Drosophila melanogaster
[Reaction:R-CEL-174389] PAPSS1,2 transfer PO4(2-) group from ATP to APS to form PAPS - Caenorhabditis elegans
[Reaction:R-SPO-174389] PAPSS1,2 transfer PO4(2-) group from ATP to APS to form PAPS - Schizosaccharomyces pombe
[Reaction:R-SCE-174389] PAPSS1,2 transfer PO4(2-) group from ATP to APS to form PAPS - Saccharomyces cerevisiae
[Reaction:R-RNO-174389] PAPSS1,2 transfer PO4(2-) group from ATP to APS to form PAPS - Rattus norvegicus
output
[SimpleEntity:R-ALL-29370] ADP [cytosol]
[SimpleEntity:R-ALL-70106] H+ [cytosol]
[SimpleEntity:R-ALL-158471] PAPS [cytosol]
precedingEvent
[Reaction:R-HSA-174392] PAPSS1,2 transfer SO4(2-) group to ATP to form APS - Homo sapiens
releaseDate
2005年09月26日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:9774232] Hill, David P, 2022年05月19日
revised
[InstanceEdit:9774231] D'Eustachio, Peter, 2022年05月19日
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-174389
summation
[Summation:176543] In the second step of PAPS biosynthesis, adenylyl sulfate (A...
updateTrackers
[UpdateTracker:9786049] Update Tracker - [Reaction:174389] PAPSS1,2 transfer PO4(2-) group from ATP to APS to form PAPS - v50:[modifyText]
[UpdateTracker:9787321] Update Tracker - [Reaction:174389] PAPSS1,2 transfer PO4(2-) group from ATP to APS to form PAPS - v45:[modifyText]
[UpdateTracker:9846973] Update Tracker - [Reaction:174389] PAPSS1,2 transfer PO4(2-) group from ATP to APS to form PAPS - v82:[addOutput]
Referrals
(precedingEvent)
[Reaction:R-HSA-741449] SLC35B2,3 exchange cytosolic PAPS with Golgi PAP
[Reaction:R-HSA-158849] Phenol can form a sulfate conjugate
[Reaction:R-HSA-176609] cholesterol + PAPS => cholesterol sulfate + PAP
[Reaction:R-HSA-176646] p-nitrophenol + PAPS => p-nitrophenol sulfate + PAP
[Reaction:R-HSA-158468] SULT1A1 dimer sulfonates PARA to PARA-SO4
[Reaction:R-HSA-176517] SULTs transfer (SO4)2- group to PREG
[Reaction:R-HSA-176585] 3,5,3'-triiodothyronine + PAPS => 3,5,3'-triiodothyronine 4-sulfate + PAP
[Reaction:R-HSA-176521] beta-estradiol + PAPS => beta-estradiol 3-sulfate + PAP
[Reaction:R-HSA-176494] SULTs transfer (SO4)2- group to 27HCHOL
[Reaction:R-HSA-158860] SULT1A1 dimer sulfonates NHABP
[Reaction:R-HSA-176588] lithocholate + PAPS => lithocholate sulfate + PAP
[Reaction:R-HSA-176631] dehydroepiandrosterone (DHEA) + PAPS => DHEA sulfate + PAP
[Reaction:R-HSA-176474] 3,3'-diiodothyronine + PAPS => 3,3'-diiodothyronine 4-sulfate + PAP
[Reaction:R-HSA-176664] estrone + PAPS => estrone 3-sulfate + PAP
[Reaction:R-HSA-159358] SULT1A3,4 dimers sulfate DA to DAOS
[Reaction:R-HSA-176604] taurolithocholate + PAPS => taurolithocholate sulfate + PAP
[Reaction:R-HSA-176669] N-hydroxy-2-acetylaminofluorene + PAPS => 2-acetylaminofluorene-N-sulfate + PAP
(hasEvent)
[Pathway:R-HSA-174362] Transport and metabolism of PAPS
(normalReaction)
[FailedReaction:R-HSA-3560785] Defective PAPSS2 does not transfer PO4(2-) group from ATP to APS to form PAPS
(updatedInstance)
[UpdateTracker:9786049] Update Tracker - [Reaction:174389] PAPSS1,2 transfer PO4(2-) group from ATP to APS to form PAPS - v50:[modifyText]
[UpdateTracker:9787321] Update Tracker - [Reaction:174389] PAPSS1,2 transfer PO4(2-) group from ATP to APS to form PAPS - v45:[modifyText]
[UpdateTracker:9846973] Update Tracker - [Reaction:174389] PAPSS1,2 transfer PO4(2-) group from ATP to APS to form PAPS - v82:[addOutput]
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