Reactome Pathway Database
Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Reactome Pathway Database
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
Schema
>
Reaction
>
Entries
Activation of C1r
Show undefined attributes
Go to Details
authored
[InstanceEdit:114498] de Bono, B, 2004年08月04日 09:17:50
catalystActivity
[CatalystActivity:173628] serine-type endopeptidase activity of Antigen:IgG:C1Q:2xC1R:2xC1S [plasma membrane]
catalystActivityReference
[CatalystActivityReference:9643521] serine-type endopeptidase activity of Antigen:IgG:C1Q:2xC1R:2xC1S [plasma membrane] The crystal structure of the zymogen catalytic domain of complement protease C1r reveals that a disruptive mechanical stress is required to trigger activation of the C1 complex
category
transition
compartment
[Compartment:984] extracellular region
[Compartment:876] plasma membrane
created
[InstanceEdit:173625] de Bono, B, 2006年02月15日 11:47:49
dbId
173626
displayName
Activation of C1r
eventOf
[Pathway:R-HSA-173623] Classical antibody-mediated complement activation - Homo sapiens
followingEvent
[Reaction:R-HSA-173631] Activation of C1s - Homo sapiens
input
[Complex:R-HSA-173582] Antigen:IgG:C1Q:2xC1R:2xC1S [plasma membrane]
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:182425] Activation of C1r by proteolytic cleavage
maxDepth
1
modified
[InstanceEdit:10680101] Weiser, Joel, 2025年08月27日
name
Activation of C1r
orthologousEvent
[BlackBoxEvent:R-GGA-2132122] Activation of C1r within the C1complement complex - Gallus gallus
[Reaction:R-GGA-173626] Activation of C1r - Gallus gallus
[Reaction:R-SSC-173626] Activation of C1r - Sus scrofa
[Reaction:R-BTA-173626] Activation of C1r - Bos taurus
[Reaction:R-CFA-173626] Activation of C1r - Canis familiaris
[Reaction:R-RNO-173626] Activation of C1r - Rattus norvegicus
[Reaction:R-MMU-173626] Activation of C1r - Mus musculus
output
[Complex:R-HSA-173619] Antigen:IgG:C1Q:2x Activated C1R:2xC1S [plasma membrane]
regulatedBy
[PositiveRegulation:R-HSA-977428] Positive regulation by 'C-reactive protein pentamer:phosphocholine:C1Q [extracellular region]'
releaseDate
2005年04月11日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:181939] D'Eustachio, P, 2006年07月03日 21:35:13
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-173626
summation
[Summation:174559] C1 activation requires interaction with two separate Fc doma...
updateTrackers
[UpdateTracker:9790115] Update Tracker - [Reaction:173626] Activation of C1r - v35:[addRegulator]
Referrals
(updatedInstance)
[UpdateTracker:9790115] Update Tracker - [Reaction:173626] Activation of C1r - v35:[addRegulator]
(hasEvent)
[Pathway:R-HSA-173623] Classical antibody-mediated complement activation
(precedingEvent)
[Reaction:R-HSA-173631] Activation of C1s
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text
Download
Close
AltStyle
によって変換されたページ
(->オリジナル)
/
アドレス:
モード:
デフォルト
音声ブラウザ
ルビ付き
配色反転
文字拡大
モバイル