Reactome Pathway Database

Schema > Reaction > Entries

Activation of C1r Show undefined attributes

catalystActivity

[CatalystActivity:10323114] serine-type endopeptidase activity of Antigen:IgG:C1Q:2xC1R:2xC1S [plasma membrane]

category transition

compartment

created [InstanceEdit:10309703] Weiser, Joel, 2025年08月27日

dbId 10323126

displayName Activation of C1r

eventOf

[Pathway:R-BTA-173623] Classical antibody-mediated complement activation - Bos taurus

evidenceType [EvidenceType:9965817] inferred by electronic annotation

followingEvent

[Reaction:R-BTA-173631] Activation of C1s - Bos taurus

inferredFrom

[Reaction:R-HSA-173626] Activation of C1r - Homo sapiens

input

[Complex:R-BTA-173582] Antigen:IgG:C1Q:2xC1R:2xC1S [plasma membrane]

isInDisease false

isInferred true

maxDepth 1

name

Activation of C1r

output

[Complex:R-BTA-173619] Antigen:IgG:C1Q:2x Activated C1R:2xC1S [plasma membrane]

regulatedBy

[PositiveRegulation:10323127] Positive regulation by 'C-reactive protein pentamer:phosphocholine:C1Q [extracellular region]'

releaseDate 2025年09月18日

schemaClass Reaction

species

[Species:48898] Bos taurus

stId R-BTA-173626

summation

[Summation:9965816] This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)

[Pathway:R-BTA-173623] Classical antibody-mediated complement activation

(precedingEvent)

[Reaction:R-BTA-173631] Activation of C1s

(inferredTo)

[Reaction:R-HSA-173626] Activation of C1r

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