Reactome Pathway Database

Schema > Reaction > Entries

TGFBR2 recruits TGFBR1 Show undefined attributes

authored

[InstanceEdit:171270] Heldin, CH, Moustakas, A, Huminiecki, L, Jassal, B, 2006年02月02日

category transition

compartment

created [InstanceEdit:170836] Jassal, B, 2006年01月18日 10:19:52

dbId 170846

displayName TGFBR2 recruits TGFBR1

edited

eventOf

[Pathway:R-HSA-2173789] TGF-beta receptor signaling activates SMADs - Homo sapiens

followingEvent

[Reaction:R-HSA-170843] TGFBR2 phosphorylates TGFBR1 - Homo sapiens

input

isInDisease false

isInferred false

literatureReference

maxDepth 1

modified [InstanceEdit:10867632] Weiser, Joel, 2025年08月27日

name

TGFBR2 recruits TGFBR1
Type II receptor recruits type I receptor

orthologousEvent

output

precedingEvent

[Reaction:R-HSA-170861] Dimeric TGF-beta-1 binds to the receptor - Homo sapiens

previousReviewStatus [ReviewStatus:9821384] two stars

regulatedBy

[PositiveRegulation:9839330] Positive regulation by 'TGFB1_2:TGFBR3:TGFBR2 [plasma membrane]'

regulationReference

[RegulationReference:9840922] Positive regulation by 'TGFB1_2:TGFBR3:TGFBR2 [plasma membrane]' Betaglycan presents ligand to the TGF beta signaling receptor

releaseDate 2006年04月24日

reviewStatus [ReviewStatus:9821385] four stars

reviewed

revised

schemaClass Reaction

species

[Species:48887] Homo sapiens

stId R-HSA-170846

summation

[Summation:176012] The protein complex of dimeric TGF-beta-1 with the type II r...

updateTrackers

Referrals

(updatedInstance)

(normalReaction)

[FailedReaction:R-HSA-3656382] TGFBR2 does not recruit TGFBR1 LBD Mutants

(hasEvent)

[Pathway:R-HSA-2173789] TGF-beta receptor signaling activates SMADs

(precedingEvent)

[Reaction:R-HSA-170843] TGFBR2 phosphorylates TGFBR1

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