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Schema
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Pathway
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Entries
Signaling by TGF-beta Receptor Complex
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authored
[InstanceEdit:171270] Heldin, CH, Moustakas, A, Huminiecki, L, Jassal, B, 2006年02月02日
created
[InstanceEdit:170836] Jassal, B, 2006年01月18日 10:19:52
dbId
170834
diseasePathways
[Pathway:R-HSA-3642279] TGFBR2 MSI Frameshift Mutants in Cancer - Homo sapiens
[Pathway:R-HSA-3645790] TGFBR2 Kinase Domain Mutants in Cancer - Homo sapiens
[Pathway:R-HSA-3656535] TGFBR1 LBD Mutants in Cancer - Homo sapiens
[Pathway:R-HSA-3656532] TGFBR1 KD Mutants in Cancer - Homo sapiens
[Pathway:R-HSA-3311021] SMAD4 MH2 Domain Mutants in Cancer - Homo sapiens
[Pathway:R-HSA-3304356] SMAD2/3 Phosphorylation Motif Mutants in Cancer - Homo sapiens
[Pathway:R-HSA-3315487] SMAD2/3 MH2 Domain Mutants in Cancer - Homo sapiens
displayName
Signaling by TGF-beta Receptor Complex
edited
[InstanceEdit:178162] Jassal, B, 2006年04月18日 13:31:36
[InstanceEdit:2187413] Jassal, B, 2012年04月10日
eventOf
[Pathway:R-HSA-9006936] Signaling by TGFB family members - Homo sapiens
figure
[Figure:1996285] /figures/Pathway_Illustrations/TGFb_72_oicr.png
goBiologicalProcess
[GO_BiologicalProcess:19282] transforming growth factor beta receptor signaling pathway
hasDiagram
true
hasEHLD
false
hasEvent
[Pathway:R-HSA-2173789] TGF-beta receptor signaling activates SMADs - Homo sapiens
[Pathway:R-HSA-2173791] TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) - Homo sapiens
[Pathway:R-HSA-2173793] Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer - Homo sapiens
isInDisease
false
isInferred
false
lastUpdatedDate
2023年09月13日
literatureReference
[LiteratureReference:1497896] New regulatory mechanisms of TGF-beta receptor function
maxDepth
4
modified
[InstanceEdit:11064438] Weiser, Joel, 2025年08月28日
name
Signaling by TGF-beta Receptor Complex
Transforming Growth Factor (TGF) beta signaling
orthologousEvent
[Pathway:R-MMU-170834] Signaling by TGF-beta Receptor Complex - Mus musculus
[Pathway:R-RNO-170834] Signaling by TGF-beta Receptor Complex - Rattus norvegicus
[Pathway:R-CFA-170834] Signaling by TGF-beta Receptor Complex - Canis familiaris
[Pathway:R-BTA-170834] Signaling by TGF-beta Receptor Complex - Bos taurus
[Pathway:R-SSC-170834] Signaling by TGF-beta Receptor Complex - Sus scrofa
[Pathway:R-DRE-170834] Signaling by TGF-beta Receptor Complex - Danio rerio
[Pathway:R-XTR-170834] Signaling by TGF-beta Receptor Complex - Xenopus tropicalis
[Pathway:R-GGA-170834] Signaling by TGF-beta Receptor Complex - Gallus gallus
[Pathway:R-DME-170834] Signaling by TGF-beta Receptor Complex - Drosophila melanogaster
[Pathway:R-CEL-170834] Signaling by TGF-beta Receptor Complex - Caenorhabditis elegans
[Pathway:R-DDI-170834] Signaling by TGF-beta Receptor Complex - Dictyostelium discoideum
[Pathway:R-SPO-170834] Signaling by TGF-beta Receptor Complex - Schizosaccharomyces pombe
[Pathway:R-SCE-170834] Signaling by TGF-beta Receptor Complex - Saccharomyces cerevisiae
[Pathway:R-PFA-170834] Signaling by TGF-beta Receptor Complex - Plasmodium falciparum
releaseDate
2006年04月24日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:178196] Heldin, CH, 2006年04月18日 14:26:12
[InstanceEdit:2250308] Huang, Tao, 2012年05月14日
[InstanceEdit:2584311] Chen, Ye-Guang, 2012年11月14日
revised
[InstanceEdit:2186634] Orlic-Milacic, M, 2012年04月04日
schemaClass
Pathway
species
[Species:48887] Homo sapiens
stId
R-HSA-170834
summation
[Summation:171269] The TGF-beta/BMP pathway incorporates several signaling path...
updateTrackers
[UpdateTracker:9788508] Update Tracker - [Pathway:170834] Signaling by TGF-beta Receptor Complex - v41:[addLiteratureReference, add_removeHasEvent, modifyText]
[UpdateTracker:9791780] Update Tracker - [Pathway:170834] Signaling by TGF-beta Receptor Complex - v26:[modifyText]
[UpdateTracker:9792516] Update Tracker - [Pathway:170834] Signaling by TGF-beta Receptor Complex - v20:[updateContainedRLE]
[UpdateTracker:9785229] Update Tracker - [Pathway:170834] Signaling by TGF-beta Receptor Complex - v52:[updateContainedPathway]
[UpdateTracker:9788960] Update Tracker - [Pathway:170834] Signaling by TGF-beta Receptor Complex - v39:[updateContainedRLE]
[UpdateTracker:9789353] Update Tracker - [Pathway:170834] Signaling by TGF-beta Receptor Complex - v38:[modifyText, updateContainedRLE]
[UpdateTracker:9774688] Update Tracker - [Pathway:170834] Signaling by TGF-beta Receptor Complex - v81:[updateContainedPathway, updateIndirectRLE]
[UpdateTracker:9788161] Update Tracker - [Pathway:170834] Signaling by TGF-beta Receptor Complex - v43:[updateIndirectRLE]
[UpdateTracker:9787233] Update Tracker - [Pathway:170834] Signaling by TGF-beta Receptor Complex - v46:[updateContainedPathway, updateIndirectRLE]
[UpdateTracker:9842349] Update Tracker - [Pathway:170834] Signaling by TGF-beta Receptor Complex - v86:[updateIndirectRLE]
[UpdateTracker:9775548] Update Tracker - [Pathway:170834] Signaling by TGF-beta Receptor Complex - v78:[updateContainedPathway, updateIndirectRLE]
[UpdateTracker:9781836] Update Tracker - [Pathway:170834] Signaling by TGF-beta Receptor Complex - v60:[updateIndirectRLE]
[UpdateTracker:9775264] Update Tracker - [Pathway:170834] Signaling by TGF-beta Receptor Complex - v80:[updateIndirectRLE]
[UpdateTracker:9775485] Update Tracker - [Pathway:170834] Signaling by TGF-beta Receptor Complex - v79:[updateContainedPathway, updateIndirectRLE]
[UpdateTracker:9777366] Update Tracker - [Pathway:170834] Signaling by TGF-beta Receptor Complex - v72:[updateIndirectRLE]
[UpdateTracker:9789737] Update Tracker - [Pathway:170834] Signaling by TGF-beta Receptor Complex - v37:[updateContainedRLE]
[UpdateTracker:9792147] Update Tracker - [Pathway:170834] Signaling by TGF-beta Receptor Complex - v23:[updateContainedRLE]
[UpdateTracker:9787682] Update Tracker - [Pathway:170834] Signaling by TGF-beta Receptor Complex - v44:[modifyText, updateContainedPathway, updateIndirectRLE]
Referrals
(hasEvent)
[Pathway:R-HSA-9006936] Signaling by TGFB family members
(hasEncapsulatedEvent)
[Pathway:R-HSA-2173793] Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
[Pathway:R-HSA-8878159] Transcriptional regulation by RUNX3
[Pathway:R-HSA-1980143] Signaling by NOTCH1
[Pathway:R-HSA-9617828] FOXO-mediated transcription of cell cycle genes
[Pathway:R-HSA-9692914] SARS-CoV-1-host interactions
[Pathway:R-HSA-9839373] Signaling by TGFBR3
(normalPathway)
[Pathway:R-HSA-3642279] TGFBR2 MSI Frameshift Mutants in Cancer
[Pathway:R-HSA-3645790] TGFBR2 Kinase Domain Mutants in Cancer
[Pathway:R-HSA-3656535] TGFBR1 LBD Mutants in Cancer
[Pathway:R-HSA-3656532] TGFBR1 KD Mutants in Cancer
[Pathway:R-HSA-3311021] SMAD4 MH2 Domain Mutants in Cancer
[Pathway:R-HSA-3304356] SMAD2/3 Phosphorylation Motif Mutants in Cancer
[Pathway:R-HSA-3315487] SMAD2/3 MH2 Domain Mutants in Cancer
(updatedInstance)
[UpdateTracker:9788508] Update Tracker - [Pathway:170834] Signaling by TGF-beta Receptor Complex - v41:[addLiteratureReference, add_removeHasEvent, modifyText]
[UpdateTracker:9791780] Update Tracker - [Pathway:170834] Signaling by TGF-beta Receptor Complex - v26:[modifyText]
[UpdateTracker:9792516] Update Tracker - [Pathway:170834] Signaling by TGF-beta Receptor Complex - v20:[updateContainedRLE]
[UpdateTracker:9785229] Update Tracker - [Pathway:170834] Signaling by TGF-beta Receptor Complex - v52:[updateContainedPathway]
[UpdateTracker:9788960] Update Tracker - [Pathway:170834] Signaling by TGF-beta Receptor Complex - v39:[updateContainedRLE]
[UpdateTracker:9789353] Update Tracker - [Pathway:170834] Signaling by TGF-beta Receptor Complex - v38:[modifyText, updateContainedRLE]
[UpdateTracker:9774688] Update Tracker - [Pathway:170834] Signaling by TGF-beta Receptor Complex - v81:[updateContainedPathway, updateIndirectRLE]
[UpdateTracker:9788161] Update Tracker - [Pathway:170834] Signaling by TGF-beta Receptor Complex - v43:[updateIndirectRLE]
[UpdateTracker:9787233] Update Tracker - [Pathway:170834] Signaling by TGF-beta Receptor Complex - v46:[updateContainedPathway, updateIndirectRLE]
[UpdateTracker:9842349] Update Tracker - [Pathway:170834] Signaling by TGF-beta Receptor Complex - v86:[updateIndirectRLE]
[UpdateTracker:9775548] Update Tracker - [Pathway:170834] Signaling by TGF-beta Receptor Complex - v78:[updateContainedPathway, updateIndirectRLE]
[UpdateTracker:9781836] Update Tracker - [Pathway:170834] Signaling by TGF-beta Receptor Complex - v60:[updateIndirectRLE]
[UpdateTracker:9775264] Update Tracker - [Pathway:170834] Signaling by TGF-beta Receptor Complex - v80:[updateIndirectRLE]
[UpdateTracker:9775485] Update Tracker - [Pathway:170834] Signaling by TGF-beta Receptor Complex - v79:[updateContainedPathway, updateIndirectRLE]
[UpdateTracker:9777366] Update Tracker - [Pathway:170834] Signaling by TGF-beta Receptor Complex - v72:[updateIndirectRLE]
[UpdateTracker:9789737] Update Tracker - [Pathway:170834] Signaling by TGF-beta Receptor Complex - v37:[updateContainedRLE]
[UpdateTracker:9792147] Update Tracker - [Pathway:170834] Signaling by TGF-beta Receptor Complex - v23:[updateContainedRLE]
[UpdateTracker:9787682] Update Tracker - [Pathway:170834] Signaling by TGF-beta Receptor Complex - v44:[modifyText, updateContainedPathway, updateIndirectRLE]
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