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Schema
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Reaction
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Entries
Assembly of an Active Transcription Complex
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authored
[InstanceEdit:193029] Bortz, E, Garcia-Sastre, A, 2007年02月12日 19:39:05
category
binding
compartment
[Compartment:7660] nucleoplasm
created
[InstanceEdit:168327] 2007年04月16日 22:35:07
crossReference
[DatabaseIdentifier:11944910] Mondo:0005812
dbId
168326
disease
[Disease:1660558] influenza
displayName
Assembly of an Active Transcription Complex
eventOf
[Pathway:R-HSA-168325] Viral Messenger RNA Synthesis - Homo sapiens
followingEvent
[Reaction:R-HSA-168280] Priming and Initiation of Transcription - Homo sapiens
goBiologicalProcess
[GO_BiologicalProcess:6686] viral transcription
input
[OtherEntity:R-ALL-158444] Mature intronless transcript derived mRNA [nucleoplasm]
[Complex:R-FLU-192720] Viral Polymerase [nucleoplasm]
[Complex:R-FLU-193302] vRNA (Genomic):NP Complex [nucleoplasm]
isInDisease
true
isInferred
false
literatureReference
[LiteratureReference:168991] Differential activation of the influenza virus polymerase via template RNA binding
[LiteratureReference:169042] A unique cap(m7GpppXm)-dependent influenza virion endonuclease cleaves capped RNAs to generate the primers that initiate viral RNA transcription
[LiteratureReference:192737] RNA-dependent activation of primer RNA production by influenza virus polymerase: different regions of the same protein subunit constitute the two required RNA-binding sites
[LiteratureReference:192890] The RNA polymerase of influenza a virus is stabilized by interaction with its viral RNA promoter
[LiteratureReference:192648] Two separate sequences of PB2 subunit constitute the RNA cap-binding site of influenza virus RNA polymerase
maxDepth
1
modified
[InstanceEdit:9830342] Matthews, Lisa, 2023年03月08日
name
Assembly of an Active Transcription Complex
output
[Complex:R-FLU-192703] vRNA Transcription Complex [nucleoplasm]
precedingEvent
[Reaction:R-HSA-192912] NP binds vRNA - Homo sapiens
[Reaction:R-HSA-192830] Viral Polymerase Assembly - Homo sapiens
regulatedBy
[PositiveRegulation:R-HSA-192796] Positive regulation by 'RNA Polymerase II (phosphorylated):TFIIF:capped pre-mRNA [nucleoplasm]'
[PositiveRegulation:R-HSA-192819] Positive regulation by 'NP [nucleoplasm]'
relatedSpecies
[Species:9031716] Influenza A virus
releaseDate
2006年01月23日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:193030] Squires, B, 2007年02月12日 19:39:22
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-168326
summation
[Summation:169032] The 5' end of the vRNA associates with a binding site on the...
updateTrackers
[UpdateTracker:9792521] Update Tracker - [Reaction:168326] Assembly of an Active Transcription Complex - v20:[addInput, addOutput, addRegulator, add_removeLiteratureReference, modifyText]
[UpdateTracker:9792461] Update Tracker - [Reaction:168326] Assembly of an Active Transcription Complex - v21:[modifyText]
Referrals
(updatedInstance)
[UpdateTracker:9792521] Update Tracker - [Reaction:168326] Assembly of an Active Transcription Complex - v20:[addInput, addOutput, addRegulator, add_removeLiteratureReference, modifyText]
[UpdateTracker:9792461] Update Tracker - [Reaction:168326] Assembly of an Active Transcription Complex - v21:[modifyText]
(hasEvent)
[Pathway:R-HSA-168325] Viral Messenger RNA Synthesis
(precedingEvent)
[Reaction:R-HSA-168280] Priming and Initiation of Transcription
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