Reactome | Collagen biosynthesis and modifying enzymes

authored

[InstanceEdit:913966] Jupe, S, 2010年07月20日

created [InstanceEdit:1650793] Jupe, S, 2011年10月12日

dbId 1650814

displayName Collagen biosynthesis and modifying enzymes

doi 10.3180/REACT_121139.1

edited

[InstanceEdit:2247551] Jupe, S, 2012年05月14日

eventOf

[Pathway:R-HSA-1474290] Collagen formation - Homo sapiens

goBiologicalProcess [GO_BiologicalProcess:20746] collagen fibril organization

hasDiagram true

hasEHLD false

hasEvent

[Reaction:R-HSA-2002460] P4HB binds Collagen chains - Homo sapiens
[Reaction:R-HSA-1650808] Prolyl 4-hydroxylase converts collagen prolines to 4-hydroxyprolines - Homo sapiens
[BlackBoxEvent:R-HSA-8948234] P4HB:4-Hyp collagen propeptides dissociates - Homo sapiens
[Reaction:R-HSA-8948230] P3HB binds 4-Hyp-collagen propeptides - Homo sapiens
[Reaction:R-HSA-1980233] Collagen prolyl 3-hydroxylase converts 4-Hyp collagen to 3,4-Hyp collagen - Homo sapiens
[BlackBoxEvent:R-HSA-8948226] Prolyl 3-hydroxylases:Fe2+:3,4-Hyp collagen propeptides dissociates - Homo sapiens
[Reaction:R-HSA-1981104] Procollagen lysyl hydroxylases convert collagen lysines to 5-hydroxylysines - Homo sapiens
[BlackBoxEvent:R-HSA-8948232] Lysyl hydroxylated collagen propeptides dissociate from Lysyl hydroxylases - Homo sapiens
[Reaction:R-HSA-8948228] COLGALT1,COLGALT2 bind Lysyl hydroxylated collagen propeptides - Homo sapiens
[Reaction:R-HSA-8948219] PLOD3 binds Lysyl hydroxylated collagen propeptides - Homo sapiens
[Reaction:R-HSA-1981120] Galactosylation of collagen propeptide hydroxylysines by procollagen galactosyltransferases 1, 2 - Homo sapiens
[Reaction:R-HSA-1981128] Galactosylation of collagen propeptide hydroxylysines by PLOD3 - Homo sapiens
[BlackBoxEvent:R-HSA-8948231] COLGALT1,COLGALT2:Galactosyl-hydroxylysyl collagen propeptides dissociates - Homo sapiens
[BlackBoxEvent:R-HSA-8948222] PLOD3:Fe2+ dimer:Galactosyl-hydroxylysyl collagen propeptides dissociates - Homo sapiens
[Reaction:R-HSA-1981157] Glucosylation of collagen propeptide hydroxylysines - Homo sapiens
[BlackBoxEvent:R-HSA-8948224] PLOD3:Fe2+ dimer:Glucosyl-galactosyl-hydroxylysyl collagen propeptides dissociates - Homo sapiens
[Pathway:R-HSA-8948216] Collagen chain trimerization - Homo sapiens
[Reaction:R-HSA-2022073] Procollagen triple helix formation - Homo sapiens
[Reaction:R-HSA-1614460] Dimerization of procollagen type VI - Homo sapiens
[Reaction:R-HSA-1614461] Tetramerization of procollagen VI - Homo sapiens
[BlackBoxEvent:R-HSA-2089971] Secretion of collagens - Homo sapiens
[BlackBoxEvent:R-HSA-2152276] Secretion of transmembrane collagens - Homo sapiens
[Reaction:R-HSA-2002428] Removal of fibrillar collagen N-propeptides - Homo sapiens
[Reaction:R-HSA-2002440] Removal of fibrillar collagen C-propeptides - Homo sapiens

isInDisease false

isInferred false

lastUpdatedDate 2017年12月18日

literatureReference

maxDepth 3

modified [InstanceEdit:10948619] Weiser, Joel, 2025年08月27日

name

Collagen biosynthesis and modifying enzymes

orthologousEvent

releaseDate 2012年06月12日

reviewStatus [ReviewStatus:9821382] five stars

reviewed

[InstanceEdit:2267224] Canty-Laird, EG, 2012年05月24日

schemaClass Pathway

species

[Species:48887] Homo sapiens

stId R-HSA-1650814

summation

[Summation:1650785] The biosynthesis of collagen is a multistep process. Collage...

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