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Schema
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Reaction
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Entries
D-glyceraldehyde 3-phosphate + sedoheptulose 7-phosphate<=> xylulose 5-phosphate+ribose 5-phosphate
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catalystActivity
[CatalystActivity:71323] transketolase activity of TKT dimer [cytosol]
catalystActivityReference
[CatalystActivityReference:9643773] transketolase activity of TKT dimer [cytosol] Aspartate 155 of human transketolase is essential for thiamine diphosphate-magnesium binding, and cofactor binding is required for dimer formation
category
transition
compartment
[Compartment:70101] cytosol
created
[InstanceEdit:163728] Gopinathrao, G, 2005年05月06日 17:09:17
crossReference
[DatabaseIdentifier:9934066] RHEA:10509
dbId
163741
displayName
D-glyceraldehyde 3-phosphate + sedoheptulose 7-phosphate<=> xylulose 5-phosphate+ribose 5-phosphate
eventOf
[Pathway:R-HSA-163754] Insulin effects increased synthesis of Xylulose-5-Phosphate - Homo sapiens
[Pathway:R-HSA-71336] Pentose phosphate pathway - Homo sapiens
input
[SimpleEntity:R-ALL-29578] GA3P [cytosol]
[SimpleEntity:R-ALL-29882] SH7P [cytosol]
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:199810] Aspartate 155 of human transketolase is essential for thiamine diphosphate-magnesium binding, and cofactor binding is required for dimer formation
maxDepth
1
modified
[InstanceEdit:10867632] Weiser, Joel, 2025年08月27日
name
D-glyceraldehyde 3-phosphate + sedoheptulose 7-phosphate<=> xylulose 5-phosphate+ribose 5-phosphate
TKT dimer transfers two-carbon ketol group onto GA3P
orthologousEvent
[Reaction:R-CEL-163741] D-glyceraldehyde 3-phosphate + sedoheptulose 7-phosphate<=> xylulose 5-phosphate+ribose 5-phosphate - Caenorhabditis elegans
[Reaction:R-DME-163741] D-glyceraldehyde 3-phosphate + sedoheptulose 7-phosphate<=> xylulose 5-phosphate+ribose 5-phosphate - Drosophila melanogaster
[Reaction:R-GGA-163741] D-glyceraldehyde 3-phosphate + sedoheptulose 7-phosphate<=> xylulose 5-phosphate+ribose 5-phosphate - Gallus gallus
[Reaction:R-XTR-163741] D-glyceraldehyde 3-phosphate + sedoheptulose 7-phosphate<=> xylulose 5-phosphate+ribose 5-phosphate - Xenopus tropicalis
[Reaction:R-SSC-163741] D-glyceraldehyde 3-phosphate + sedoheptulose 7-phosphate<=> xylulose 5-phosphate+ribose 5-phosphate - Sus scrofa
[Reaction:R-BTA-163741] D-glyceraldehyde 3-phosphate + sedoheptulose 7-phosphate<=> xylulose 5-phosphate+ribose 5-phosphate - Bos taurus
[Reaction:R-CFA-163741] D-glyceraldehyde 3-phosphate + sedoheptulose 7-phosphate<=> xylulose 5-phosphate+ribose 5-phosphate - Canis familiaris
[Reaction:R-RNO-163741] D-glyceraldehyde 3-phosphate + sedoheptulose 7-phosphate<=> xylulose 5-phosphate+ribose 5-phosphate - Rattus norvegicus
[Reaction:R-MMU-163741] D-glyceraldehyde 3-phosphate + sedoheptulose 7-phosphate<=> xylulose 5-phosphate+ribose 5-phosphate - Mus musculus
output
[SimpleEntity:R-ALL-73578] R5P [cytosol]
[SimpleEntity:R-ALL-29790] XY5P [cytosol]
precedingEvent
[Reaction:R-HSA-70454] TPI1 dimer isomerizes DHAP to GA3P - Homo sapiens
[Reaction:R-HSA-163764] D-fructose 6-phosphate + D-erythrose 4-phosphate <=> sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate - Homo sapiens
releaseDate
2005年09月26日
reverseReaction
[Reaction:R-HSA-71324] ribose 5-phosphate + xylulose 5-phosphate <=> sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate
reviewStatus
[ReviewStatus:9821382] five stars
revised
[InstanceEdit:469644] D'Eustachio, P, 2010年01月24日
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-163741
summation
[Summation:178634] Cytosolic transketolase (TKT) catalyzes the reversible react...
updateTrackers
[UpdateTracker:9791027] Update Tracker - [Reaction:163741] D-glyceraldehyde 3-phosphate + sedoheptulose 7-phosphate<=> xylulose 5-phosphate+ribose 5-phosphate - v32:[modifyText]
[UpdateTracker:9792271] Update Tracker - [Reaction:163741] D-glyceraldehyde 3-phosphate + sedoheptulose 7-phosphate<=> xylulose 5-phosphate+ribose 5-phosphate - v22:[addLiteratureReference]
[UpdateTracker:9864189] Update Tracker - [Reaction:163741] D-glyceraldehyde 3-phosphate + sedoheptulose 7-phosphate<=> xylulose 5-phosphate+ribose 5-phosphate - v88:[modifyText]
[UpdateTracker:9781228] Update Tracker - [Reaction:163741] D-glyceraldehyde 3-phosphate + sedoheptulose 7-phosphate<=> xylulose 5-phosphate+ribose 5-phosphate - v61:[modifyText]
Referrals
(updatedInstance)
[UpdateTracker:9791027] Update Tracker - [Reaction:163741] D-glyceraldehyde 3-phosphate + sedoheptulose 7-phosphate<=> xylulose 5-phosphate+ribose 5-phosphate - v32:[modifyText]
[UpdateTracker:9792271] Update Tracker - [Reaction:163741] D-glyceraldehyde 3-phosphate + sedoheptulose 7-phosphate<=> xylulose 5-phosphate+ribose 5-phosphate - v22:[addLiteratureReference]
[UpdateTracker:9864189] Update Tracker - [Reaction:163741] D-glyceraldehyde 3-phosphate + sedoheptulose 7-phosphate<=> xylulose 5-phosphate+ribose 5-phosphate - v88:[modifyText]
[UpdateTracker:9781228] Update Tracker - [Reaction:163741] D-glyceraldehyde 3-phosphate + sedoheptulose 7-phosphate<=> xylulose 5-phosphate+ribose 5-phosphate - v61:[modifyText]
(hasEvent)
[Pathway:R-HSA-163754] Insulin effects increased synthesis of Xylulose-5-Phosphate
[Pathway:R-HSA-71336] Pentose phosphate pathway
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