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NEXT2 is cleaved to produce NICD2 Show undefined attributes

authored

[InstanceEdit:157021] Jassal, B, 2004年12月15日 13:08:03

catalystActivity

[CatalystActivity:157355] aspartic-type endopeptidase activity of gamma-secretase complex [plasma membrane]

category transition

compartment

created [InstanceEdit:157354] Jassal, B, 2004年12月21日 14:32:26

dbId 157640

displayName NEXT2 is cleaved to produce NICD2

edited

[InstanceEdit:3159303] Haw, R, 2013年01月14日

eventOf

[Pathway:R-HSA-2979096] NOTCH2 Activation and Transmission of Signal to the Nucleus - Homo sapiens

followingEvent

[Reaction:R-HSA-157933] NICD2 traffics to the nucleus - Homo sapiens

inferredFrom

[Reaction:R-NUL-2197556] Gamma-secretase complex cleaves mNEXT2 - Homo sapiens

input

[EntityWithAccessionedSequence:R-HSA-157225] NEXT2 [plasma membrane]

isInDisease false

isInferred true

literatureReference

maxDepth 1

modified [InstanceEdit:9830342] Matthews, Lisa, 2023年03月08日

name

NEXT2 is cleaved to produce NICD2

output

precedingEvent

[Reaction:R-HSA-157629] NOTCH2-ligand complex is cleaved to produce NEXT2 - Homo sapiens

releaseDate 2013年06月11日

reviewStatus [ReviewStatus:9821382] five stars

reviewed

revised

[InstanceEdit:2980678] Orlic-Milacic, M, 2013年01月11日

schemaClass Reaction

species

[Species:48887] Homo sapiens

stId R-HSA-157640

summation

[Summation:178971] NEXT2 fragment of NOTCH2 is further cleaved at the S3 site b...

updateTrackers

Referrals

(updatedInstance)

(precedingEvent)

[Reaction:R-HSA-157933] NICD2 traffics to the nucleus

(hasEvent)

[Pathway:R-HSA-2979096] NOTCH2 Activation and Transmission of Signal to the Nucleus

(inferredTo)

[Reaction:R-NUL-2197556] Gamma-secretase complex cleaves mNEXT2

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