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NOTCH2-ligand complex is cleaved to produce NEXT2 Show undefined attributes

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authored

[InstanceEdit:2980678] Orlic-Milacic, M, 2013年01月11日

catalystActivity

[CatalystActivity:157208] metallopeptidase activity of ADAM10:Zn2+ [plasma membrane]

category transition

compartment

[Compartment:876] plasma membrane

created [InstanceEdit:157631] Jassal, B, 2005年01月04日 16:01:41

dbId 157629

displayName NOTCH2-ligand complex is cleaved to produce NEXT2

edited

[InstanceEdit:3159303] Haw, R, 2013年01月14日

entityOnOtherCell

eventOf

[Pathway:R-HSA-2979096] NOTCH2 Activation and Transmission of Signal to the Nucleus - Homo sapiens

followingEvent

[Reaction:R-HSA-157640] NEXT2 is cleaved to produce NICD2 - Homo sapiens

inferredFrom

[Reaction:R-MMU-2193065] Adam10 cleaves Notch2 - Mus musculus

input

[Complex:R-HSA-2172171] Ub-DLL/JAG:NOTCH2 [plasma membrane]

isInDisease false

isInferred true

literatureReference

maxDepth 1

modified [InstanceEdit:9830342] Matthews, Lisa, 2023年03月08日

name

NOTCH2-ligand complex is cleaved to produce NEXT2

output

precedingEvent

[Reaction:R-HSA-2172172] Ubiquitination of DLL/JAG ligands upon binding to NOTCH2 - Homo sapiens

releaseDate 2013年06月11日

reviewStatus [ReviewStatus:9821382] five stars

reviewed

schemaClass Reaction

species

[Species:48887] Homo sapiens

stId R-HSA-157629

summation

[Summation:178988] Ligand binding induces a conformational change in NOTCH2, th...

updateTrackers

Referrals

(updatedInstance)

(hasEvent)

[Pathway:R-HSA-2979096] NOTCH2 Activation and Transmission of Signal to the Nucleus

(precedingEvent)

[Reaction:R-HSA-157640] NEXT2 is cleaved to produce NICD2

(inferredTo)

[Reaction:R-MMU-2193065] Adam10 cleaves Notch2

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