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Schema
>
Complex
>
Entries
ERBB2:ERBIN:HSP90:CDC37 [plasma membrane]
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compartment
[Compartment:876] plasma membrane
consumedByEvent
[Reaction:R-HSA-1227964] ERBB2 homodimerization - Homo sapiens
[Reaction:R-HSA-1227964] ERBB2 homodimerization - Homo sapiens
[Reaction:R-HSA-1918095] CUL5 mediates ubiquitination of ERBB2 - Homo sapiens
[Reaction:R-HSA-1918092] CHIP (STUB1) mediates ubiquitination of ERBB2 - Homo sapiens
[Reaction:R-HSA-9665726] ERBB2 binds pertuzumab - Homo sapiens
[Reaction:R-HSA-9652264] ERBB2 binds TKIs - Homo sapiens
[Reaction:R-HSA-9652277] ERBB2 binds trastuzumab - Homo sapiens
[Reaction:R-HSA-1963589] ERBB2 forms heterodimers with ligand-activated ERBB receptors: EGFR, ERBB3 and ERBB4 - Homo sapiens
[Reaction:R-HSA-1963589] ERBB2 forms heterodimers with ligand-activated ERBB receptors: EGFR, ERBB3 and ERBB4 - Homo sapiens
[Reaction:R-HSA-1963589] ERBB2 forms heterodimers with ligand-activated ERBB receptors: EGFR, ERBB3 and ERBB4 - Homo sapiens
[Reaction:R-HSA-1963589] ERBB2 forms heterodimers with ligand-activated ERBB receptors: EGFR, ERBB3 and ERBB4 - Homo sapiens
created
[InstanceEdit:1227968] Orlic-Milacic, Marija, 2011年03月14日
dbId
1227970
displayName
ERBB2:ERBIN:HSP90:CDC37 [plasma membrane]
hasComponent
[Complex:R-HSA-1225828] CDC37 [cytosol]
[EntityWithAccessionedSequence:R-HSA-372889] ERBB2 [plasma membrane]
[EntityWithAccessionedSequence:R-HSA-1358718] ERBIN [plasma membrane]
[Complex:R-HSA-1221657] HSP90 [cytosol]
inDisease
false
includedLocation
[Compartment:70101] cytosol
inferredTo
[Complex:R-MMU-1227970] ERBB2:ERBIN:HSP90:CDC37 [plasma membrane] - Mus musculus
[Complex:R-RNO-1227970] ERBB2:ERBIN:HSP90:CDC37 [plasma membrane] - Rattus norvegicus
[Complex:R-CFA-1227970] ERBB2:ERBIN:HSP90:CDC37 [plasma membrane] - Canis familiaris
[Complex:R-BTA-1227970] ERBB2:ERBIN:HSP90:CDC37 [plasma membrane] - Bos taurus
[Complex:R-SSC-1227970] ERBB2:ERBIN:HSP90:CDC37 [plasma membrane] - Sus scrofa
[Complex:R-DRE-1227970] ERBB2:ERBIN:HSP90:CDC37 [plasma membrane] - Danio rerio
[Complex:R-GGA-1227970] ERBB2:ERBIN:HSP90:CDC37 [plasma membrane] - Gallus gallus
[Complex:R-DME-1227970] ERBB2:ERBIN:HSP90:CDC37 [plasma membrane] - Drosophila melanogaster
[Complex:R-CEL-1227970] ERBB2:ERBIN:HSP90:CDC37 [plasma membrane] - Caenorhabditis elegans
isChimeric
false
maxDepth
3
modified
[InstanceEdit:9646486] Orlic-Milacic, Marija, 2019年05月24日
name
ERBB2:ERBIN:HSP90:CDC37
schemaClass
Complex
species
[Species:48887] Homo sapiens
stId
R-HSA-1227970
updateTrackers
[UpdateTracker:9872093] Update Tracker - [Complex:1227970] ERBB2:ERBIN:HSP90:CDC37 [plasma membrane] - v41:[removeCompartment]
[UpdateTracker:9900855] Update Tracker - [Complex:1227970] ERBB2:ERBIN:HSP90:CDC37 [plasma membrane] - v70:[modifyName]
Referrals
(updatedInstance)
[UpdateTracker:9872093] Update Tracker - [Complex:1227970] ERBB2:ERBIN:HSP90:CDC37 [plasma membrane] - v41:[removeCompartment]
[UpdateTracker:9900855] Update Tracker - [Complex:1227970] ERBB2:ERBIN:HSP90:CDC37 [plasma membrane] - v70:[modifyName]
(input)
[Reaction:R-HSA-1227964] ERBB2 homodimerization
[Reaction:R-HSA-1918095] CUL5 mediates ubiquitination of ERBB2
[Reaction:R-HSA-1918092] CHIP (STUB1) mediates ubiquitination of ERBB2
[Reaction:R-HSA-9665726] ERBB2 binds pertuzumab
[Reaction:R-HSA-9652264] ERBB2 binds TKIs
[Reaction:R-HSA-9652277] ERBB2 binds trastuzumab
[Reaction:R-HSA-1963589] ERBB2 forms heterodimers with ligand-activated ERBB receptors: EGFR, ERBB3 and ERBB4
(normalEntity)
[EntityFunctionalStatus:9665307] loss_of_function of ERBB2 T862A:ERBIN:HSP90:CDC37 [plasma membrane]
[EntityFunctionalStatus:9665302] loss_of_function of ERBB2 T733I:ERBIN:HSP90:CDC37 [plasma membrane]
[EntityFunctionalStatus:9665275] loss_of_function of ERBB2 KD mutants (neratinib resistant):ERBIN:HSP90:CDC37 [plasma membrane]
[EntityFunctionalStatus:9665270] loss_of_function of ERBB2 KD mutants (osimertinib resistant):ERBIN:HSP90:CDC37 [plasma membrane]
[EntityFunctionalStatus:9665310] loss_of_function of ERBB2 T798M:ERBIN:HSP90:CDC37 [plasma membrane]
[EntityFunctionalStatus:9665235] loss_of_function of ERBB2 KD mutants (trastuzumab resistant):ERBIN:HSP90:CDC37 [plasma membrane]
[EntityFunctionalStatus:9665277] loss_of_function of ERBB2 KD mutants (AEE788 resistant):ERBIN:HSP90:CDC37 [plasma membrane]
[EntityFunctionalStatus:9665279] loss_of_function of ERBB2 KD mutants (lapatinib resistant):ERBIN:HSP90:CDC37 [plasma membrane]
[EntityFunctionalStatus:9665966] loss_of_function of ERBB2 TMD/JMD mutants (pertuzumab resistant):ERBIN:HSP90:CDC37 [plasma membrane]
[EntityFunctionalStatus:9665378] gain_of_function of ERBB2 ECD mutants:ERBIN:HSP90:CDC37 [plasma membrane]
[EntityFunctionalStatus:9664569] gain_of_function of ERBB2 KD mutants:ERBIN:HSP90:CDC37 [plasma membrane]
[EntityFunctionalStatus:9820554] gain_of_function of ERBB2 TMD/JMD mutants (TKI sensitive):ERBIN:HSP90:CDC37 [plasma membrane]
[EntityFunctionalStatus:9820556] gain_of_function of ERBB2 R678Q:ERBIN:HSP90:CDC37 [plasma membrane]
[EntityFunctionalStatus:9820555] gain_of_function of ERBB2 TMD/JMD mutants (trastuzumab):ERBIN:HSP90:CDC37 [plasma membrane]
[EntityFunctionalStatus:9665889] gain_of_function of ERBB2 TMD/JMD mutants:ERBIN:HSP90:CDC37 [plasma membrane]
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