Reactome Pathway Database

Schema > EntityFunctionalStatus > Entries

loss_of_function of ERBB2 KD mutants (neratinib resistant):ERBIN:HSP90:CDC37 [plasma membrane] Show undefined attributes

created [InstanceEdit:9665281] Orlic-Milacic, Marija, 2019年10月30日

dbId 9665275

diseaseEntity [Complex:R-HSA-9665273] ERBB2 KD mutants (neratinib resistant):ERBIN:HSP90:CDC37 [plasma membrane]

displayName loss_of_function of ERBB2 KD mutants (neratinib resistant):ERBIN:HSP90:CDC37 [plasma membrane]

functionalStatus

[FunctionalStatus:2317386] loss_of_function via missense_variant

modified [InstanceEdit:9666683] Orlic-Milacic, Marija, 2019年11月05日

normalEntity [Complex:R-HSA-1227970] ERBB2:ERBIN:HSP90:CDC37 [plasma membrane]

schemaClass EntityFunctionalStatus

Referrals

(entityFunctionalStatus)

[FailedReaction:R-HSA-9665286] Resistant ERBB2 KD mutants do not bind neratinib

© 2025 Reactome

Cite Us!