Reactome Pathway Database

Schema > Reaction > Entries

methylmalonate semialdehyde + NAD+ + CoA + H2O => propionyl-CoA + HCO3- + NADH + H+ Show undefined attributes

catalystActivity

[CatalystActivity:10681827] methylmalonate-semialdehyde dehydrogenase (acylating, NAD) activity of ALDH6A1 [mitochondrial matrix]

category transition

compartment

[Compartment:5460] mitochondrial matrix

created [InstanceEdit:10680101] Weiser, Joel, 2025年08月27日

dbId 10681829

displayName methylmalonate semialdehyde + NAD+ + CoA + H2O => propionyl-CoA + HCO3- + NADH + H+

eventOf

[Pathway:R-GGA-70895] Branched-chain amino acid catabolism - Gallus gallus

evidenceType [EvidenceType:9965817] inferred by electronic annotation

followingEvent

[Reaction:R-GGA-71031] propionyl-CoA + CO2 + ATP <=> D-methylmalonyl-CoA + ADP + orthophosphate - Gallus gallus

inferredFrom

[Reaction:R-HSA-70893] methylmalonate semialdehyde + NAD+ + CoA + H2O => propionyl-CoA + HCO3- + NADH + H+ - Homo sapiens

input

isInDisease false

isInferred true

maxDepth 1

name

methylmalonate semialdehyde + NAD+ + CoA + H2O => propionyl-CoA + HCO3- + NADH + H+
(S)-2-methyl-3-oxopropanoate + CoA + H2O + NAD(+) => H(+) + hydrogencarbonate + NADH + propanoyl-CoA

output

precedingEvent

[Reaction:R-GGA-70885] beta-hydroxyisobutyrate + NAD+ <=> methylmalonyl semialdehyde + NADH + H+ - Gallus gallus

releaseDate 2025年09月18日

schemaClass Reaction

species

[Species:49591] Gallus gallus

stId R-GGA-70893

summation

[Summation:9965816] This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)

[Pathway:R-GGA-70895] Branched-chain amino acid catabolism

(precedingEvent)

[Reaction:R-GGA-71031] propionyl-CoA + CO2 + ATP <=> D-methylmalonyl-CoA + ADP + orthophosphate

(inferredTo)

[Reaction:R-HSA-70893] methylmalonate semialdehyde + NAD+ + CoA + H2O => propionyl-CoA + HCO3- + NADH + H+

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