Reactome Pathway Database

Schema > Reaction > Entries

beta-hydroxyisobutyrate + NAD+ <=> methylmalonyl semialdehyde + NADH + H+ Show undefined attributes

catalystActivity

[CatalystActivity:10681820] 3-hydroxyisobutyrate dehydrogenase activity of HIBADH tetramer [mitochondrial matrix]

category transition

compartment

[Compartment:5460] mitochondrial matrix

created [InstanceEdit:10680101] Weiser, Joel, 2025年08月27日

dbId 10681822

displayName beta-hydroxyisobutyrate + NAD+ <=> methylmalonyl semialdehyde + NADH + H+

eventOf

[Pathway:R-GGA-70895] Branched-chain amino acid catabolism - Gallus gallus

evidenceType [EvidenceType:9965817] inferred by electronic annotation

followingEvent

[Reaction:R-GGA-70893] methylmalonate semialdehyde + NAD+ + CoA + H2O => propionyl-CoA + HCO3- + NADH + H+ - Gallus gallus

inferredFrom

[Reaction:R-HSA-70885] beta-hydroxyisobutyrate + NAD+ <=> methylmalonyl semialdehyde + NADH + H+ - Homo sapiens

input

isInDisease false

isInferred true

maxDepth 1

name

beta-hydroxyisobutyrate + NAD+ <=> methylmalonyl semialdehyde + NADH + H+
(S)-3-hydroxy-2-methylpropanoate + NAD(+) => (S)-2-methyl-3-oxopropanoate + H(+) + NADH

output

precedingEvent

[Reaction:R-GGA-70881] beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA - Gallus gallus

releaseDate 2025年09月18日

schemaClass Reaction

species

[Species:49591] Gallus gallus

stId R-GGA-70885

summation

[Summation:9965816] This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)

[Pathway:R-GGA-70895] Branched-chain amino acid catabolism

(precedingEvent)

[Reaction:R-GGA-70893] methylmalonate semialdehyde + NAD+ + CoA + H2O => propionyl-CoA + HCO3- + NADH + H+

(inferredTo)

[Reaction:R-HSA-70885] beta-hydroxyisobutyrate + NAD+ <=> methylmalonyl semialdehyde + NADH + H+

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