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Go!
Schema
>
Complex
>
Entries
nsp15 hexamer [cytosol]
Show undefined attributes
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compartment
[Compartment:70101] cytosol
componentOf
[Complex:R-HSA-9682726] nsp15:RB1 [cytosol] - Homo sapiens
consumedByEvent
[Reaction:R-HSA-9682712] nsp15 binds RB1 - Homo sapiens
[Reaction:R-HSA-9683393] nsp15 binds nsp8 - Homo sapiens
created
[InstanceEdit:9682717] Orlic-Milacic, Marija, 2020年04月13日
crossReference
[DatabaseIdentifier:11944911] Mondo:0005091
dbId
9682715
disease
[Disease:9678120] severe acute respiratory syndrome
displayName
nsp15 hexamer [cytosol]
hasComponent
6 ×
[EntityWithAccessionedSequence:R-COV-9678288] pp1ab-nsp15 [cytosol]
inDisease
true
inferredTo
[Complex:R-COV-9694570] nsp15 hexamer [cytosol] - Severe acute respiratory syndrome coronavirus 2
isChimeric
false
literatureReference
[LiteratureReference:9682714] The coronavirus endoribonuclease Nsp15 interacts with retinoblastoma tumor suppressor protein
[LiteratureReference:9683204] Structural and functional analyses of the severe acute respiratory syndrome coronavirus endoribonuclease Nsp15
[LiteratureReference:9683208] Crystal structure of a monomeric form of severe acute respiratory syndrome coronavirus endonuclease nsp15 suggests a role for hexamerization as an allosteric switch
[LiteratureReference:9683220] Crystal structure and mechanistic determinants of SARS coronavirus nonstructural protein 15 define an endoribonuclease family
[LiteratureReference:9683386] RNA recognition and cleavage by the SARS coronavirus endoribonuclease
[LiteratureReference:9683389] Mutational analysis of the SARS virus Nsp15 endoribonuclease: identification of residues affecting hexamer formation
maxDepth
2
modified
[InstanceEdit:9698636] Cook, Justin, 2020年08月27日
name
nsp15 hexamer
producedByEvent
[Reaction:R-HSA-9682718] nsp15 forms a hexamer - Homo sapiens
schemaClass
Complex
species
[Species:9678119] Human SARS coronavirus
stId
R-COV-9682715
Referrals
(activeUnit)
[CatalystActivity:9705953] RNA endonuclease activity producing 3'-phosphomonoesters, hydrolytic mechanism of RTC [double membrane vesicle viral factory outer membrane]
[NegativeRegulation:9693594] Negative regulation by 'RTC [double membrane vesicle viral factory outer membrane]'
(hasComponent)
[Complex:R-HSA-9682726] nsp15:RB1 [cytosol]
[Complex:R-COV-9683403] nsp7:nsp8:nsp12:nsp14:nsp10:nsp13:nsp15 [cytosol]
(input)
[Reaction:R-HSA-9682712] nsp15 binds RB1
[Reaction:R-HSA-9683393] nsp15 binds nsp8
(output)
[Reaction:R-HSA-9682718] nsp15 forms a hexamer
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