Reactome Pathway Database

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Activated TRAF6:p-IRAK2 interacts with TAK1 complex upon TLR7/8 or 9 stimulation Show undefined attributes

category binding

compartment

created [InstanceEdit:10309703] Weiser, Joel, 2025年08月27日

dbId 10349385

displayName Activated TRAF6:p-IRAK2 interacts with TAK1 complex upon TLR7/8 or 9 stimulation

eventOf

[Pathway:R-BTA-975163] IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation - Bos taurus

evidenceType [EvidenceType:9965817] inferred by electronic annotation

followingEvent

[Reaction:R-BTA-975103] Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 upon TLR7/8 or 9 activation - Bos taurus

inferredFrom

[Reaction:R-HSA-975097] Activated TRAF6:p-IRAK2 interacts with TAK1 complex upon TLR7/8 or 9 stimulation - Homo sapiens

input

isInDisease false

isInferred true

maxDepth 1

name

Activated TRAF6:p-IRAK2 interacts with TAK1 complex upon TLR7/8 or 9 stimulation

output

[Complex:R-BTA-975099] p-IRAK2:K63-linked pUb oligo-TRAF6:free K63 pUb:TAK1 complex [endosome membrane]

precedingEvent

releaseDate 2025年09月18日

schemaClass Reaction

species

[Species:48898] Bos taurus

stId R-BTA-975097

summation

[Summation:9965816] This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)

[Pathway:R-BTA-975163] IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation

(precedingEvent)

[Reaction:R-BTA-975103] Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 upon TLR7/8 or 9 activation

(inferredTo)

[Reaction:R-HSA-975097] Activated TRAF6:p-IRAK2 interacts with TAK1 complex upon TLR7/8 or 9 stimulation

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