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9938225
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PD-L1 (CD274) glycosylation plays a critical role in determi...
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Summation
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PD-L1 (CD274) glycosylation plays a critical role in determining the protein function and stability. PD-L1 is N-glycosylated at N192, N200 and N219 by the OST complex (STT3A and STT3A) in the ER lumen. This process is important for PD-L1 stability and inhibits its targeting for proteasomal degradation by GSK3B (Li et al., 2016, Hsu et al., 2018). Also, JAK1 activated by the IL6 pathway positively regulate the glycosylation process by aiding in the recruitment of endoplasmic reticulum-associated N-glycosyltransferase STT3A (part of the OST-A complex) to catalyse PD-L1 glycosylation (Chan et al., 2019).