Reactome Pathway Database

Schema > EntityFunctionalStatus > Entries

loss_of_function of pT41,S45-CTNNB1 S37 mutants:Axin:GSK3:CK1alpha:APC:PP2A:AMER1 complex [cytosol] Show undefined attributes

created [InstanceEdit:4839618] Rothfels, K, 2013年11月01日

dbId 4839620

diseaseEntity [Complex:R-HSA-4839622] pT41,S45-CTNNB1 S37 mutants:Axin:GSK3:CK1alpha:APC:PP2A:AMER1 complex [cytosol]

displayName loss_of_function of pT41,S45-CTNNB1 S37 mutants:Axin:GSK3:CK1alpha:APC:PP2A:AMER1 complex [cytosol]

functionalStatus

[FunctionalStatus:2317386] loss_of_function via missense_variant

modified [InstanceEdit:9631717] Wu, G, 2018年12月12日

normalEntity [Complex:R-HSA-195313] p-T41,S45 CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol]

schemaClass EntityFunctionalStatus

Referrals

(entityFunctionalStatus)

[FailedReaction:R-HSA-4839635] CTNNB1 S37 mutants aren't phosphorylated by GSK3beta

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