Glycoscience: Biology and Medicine

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Editors:

• Tamao Endo ⁰ ,
• Peter H. Seeberger ¹ ,
• Gerald W. Hart ² ,
• Chi-Huey Wong ³ ,
• …
• Naoyuki Taniguchi ⁴

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1. Tamao Endo

   1. Tokyo Metropolitan Institute of Gerontology, Tokyo Metropolitan Geriatric Hospital, Tokyo, Japan
      

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2. Peter H. Seeberger

   1. Department of Biomolecular Systems, Max-Planck-Institute of Colloids and Interfaces, Potsdam, Germany
      

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3. Gerald W. Hart

   1. Dept. Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, USA
      

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4. Chi-Huey Wong

   1. Academia Sinica, Nankang, Taipei, Taiwan
      

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5. Naoyuki Taniguchi

   1. Systems Glycobiology Group, RIKEN-Max Planck Joint Research Center for Systems Chemical Biology, Wako, Japan
      

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The aim of the book is to provide a succinct overview of the current status of glycoscience from both basic biological and medical points of view and to propose future directions, in order to facilitate further integrations of glycoscience with other fields in biological and medical studies.
Glycans (carbohydrate oligomers) are the so-called "building blocks" of carbohydrates, nucleic acids, proteins and lipids and play major roles in many biological phenomena as well as in various pathophysiological processes. However, this area of glycoscience has been neglected from the research community because glycan structures are very complex and functionally diverse and as compared to proteins and nucleic acids simple tools for the amplification, sequencing and auto-synthesis of glycans are not available. Many scientists in other fields of research have now realized that glycosylation, i.e. the addition of glycans to a protein backbone, is the most abundant post translational modification reactions and is an important field of research and sometimes they require a glycobiology and/or glycochemistry approach to be used. It is still difficult, however, for non-expert researchers to use these techniques. This book will provide numerous but simple overviews of current topics and protocols for the experiments. The book is aimed at university students and above, including non-experts in the field of glycoscience.

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1. Polylactosamine and Immunity

   • Akira Togayachi

2. Polysialic Acid

   • Chihiro Sato, Ken Kitajima

3. Polysialyltransferase Assay

   • Masaya Hane, Ken Kitajima, Chihiro Sato

4. Preparation of Glycan Array and Its Applications

   • Chung-Yi Wu, Chi-Huey Wong

5. Problems and Pitfalls of Residue Notation in Glycoinformatics

   • Thomas Lütteke

6. Profiling of Glucosylceramides by Liquid Chromatography-Tandem Mass Spectrometry

   • Kazuki Nakajima, Ayako Kohyama-Koganeya, Yoshio Hirabayashi

7. Protein O-GalNAc Glycosylation: The Most Complex and Differentially Regulated PTM

   • Hiren J. Joshi, Catharina Steentoft, Katrine T.-B. G. Schjoldager, Sergey Y. Vakhrushev, Hans H. Wandall, Henrik Clausen

8. Quantification of Prostate Cancer-Associated Aberrant Glycosylation of Prostate-Specific Antigen

   • Chikara Ohyama, Takuya Koie, Tohru Yoneyama, Yuki Tobisawa

9. Raft Signaling

   • Kohji Kasahara

10. rBC2LCN, a Novel Lectin Probe for Human Pluripotent Stem Cells

    • Hiroaki Tateno

11. Retrograde Membrane Traffic and Recycling Endosome

    • Yuichi Takeda, Tomohiko Taguchi

12. Rheumatoid Arthritis and IgG as Biomarker

    • Shiro Ohshima

13. RINGS

    • Kiyoko F. Aoki-Kinoshita

14. Role of Heparan Sulfate Proteoglycans in Central Synapses

    • Yu Yamaguchi, Fumitoshi Irie

15. Role of Mucin-Type O-Glycan in Megakaryocyte Differentiation

    • Takashi Kudo, Satoru Takahashi

16. Role of UDP-Glucose/Glycoprotein Glucosyltransferase in ER Glycoprotein Quality Control

    • Cecilia D’Alessio, Armando J. Parodi

17. Roles of the Nutrient Sensor, O-GlcNAcylation , in Chronic Diseases of Aging

    • Gerald W. Hart

18. Sialic Acid and Cancer

    • Sylvain Julien, Philippe Delannoy

19. Sialyl Sulfoglycans in Immune Regulation and Their Clinical Applications

    • Reiji Kannagi, Keiichiro Sakuma, Katsuyuki Ohmori

20. Siglec Interactions with Pathogens

    • Takashi Angata, Ajit Varki

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• Tokyo Metropolitan Institute of Gerontology, Tokyo Metropolitan Geriatric Hospital, Tokyo, Japan

  Tamao Endo

• Department of Biomolecular Systems, Max-Planck-Institute of Colloids and Interfaces, Potsdam, Germany

  Peter H. Seeberger

• Dept. Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, USA

  Gerald W. Hart

• Academia Sinica, Nankang, Taipei, Taiwan

  Chi-Huey Wong

• Systems Glycobiology Group, RIKEN-Max Planck Joint Research Center for Systems Chemical Biology, Wako, Japan

  Naoyuki Taniguchi

Naoyuki Taniguchi is with RIKEN, Japan.
Tamao Endo is with Tokyo. Metropolitan Institute of Gerontology, Japan.
Gerald Hart is with Johns Hopkins University, USA.
Peter Seeberger is with Max Planck Institute, Germany.
Chi-Huey Wong is with Academia Sinica, Taiwan.
The co-editors are Jin-ichi Inokuchi, Ken Kitajima, Shoko Nishihara, Yasuhiro Kajihara, Kenji Kadomatsu, Takashi Angata, and Yoshiki Yamaguchi.

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