Cover
Invasive plants facilitated by socioeconomic change harbor vectors of scrub typhus and spotted fever
Aggressively out-competing native plants, invasive plants can not only have devastating effects on ecosystems but also provide ideal habitats for arthropod disease vectors. This photo shows the whole mountain in an island of Taiwan is invaded by the exotic white popinac. Wei, et al. (2020)
Image Credit: Chi-Chien Kuo
Editorials
World neglected tropical diseases day
Peter J. Hotez, Serap Aksoy, Paul J. Brindley, Shaden Kamhawi
PLOS Neglected Tropical Diseases: published January 29, 2020 | https://doi.org/10.1371/journal.pntd.0007999
What constitutes a neglected tropical disease?
Peter J. Hotez, Serap Aksoy, Paul J. Brindley, Shaden Kamhawi
PLOS Neglected Tropical Diseases: published January 30, 2020 | https://doi.org/10.1371/journal.pntd.0008001
Viewpoints
Beyond frontiers: On invasive alien mosquito species in America and Europe
André B. B. Wilke, Giovanni Benelli, John C. Beier
PLOS Neglected Tropical Diseases: published January 9, 2020 | https://doi.org/10.1371/journal.pntd.0007864
Reviews
The importance of vector control for the control and elimination of vector-borne diseases
Anne L. Wilson, Orin Courtenay, Louise A. Kelly-Hope, Thomas W. Scott, Willem Takken, Steve J. Torr, Steve W. Lindsay
PLOS Neglected Tropical Diseases: published January 16, 2020 | https://doi.org/10.1371/journal.pntd.0007831
Reassessing therapeutic antibodies for neglected and tropical diseases
Rob Hooft van Huijsduijnen, Somei Kojima, Dee Carter, Hisafumi Okabe, Akihide Sato, Wataru Akahata, Timothy N. C. Wells, Kei Katsuno
PLOS Neglected Tropical Diseases: published January 30, 2020 | https://doi.org/10.1371/journal.pntd.0007860
Research Articles
A quantitative comparison of West Nile virus incidence from 2013 to 2018 in Emilia-Romagna, Italy
Giovanni Marini, Mattia Calzolari, Paola Angelini, Romeo Bellini, Silvia Bellini, Luca Bolzoni, Deborah Torri, Francesco Defilippo, Ilaria Dorigatti, Birgit Nikolay, Andrea Pugliese, Roberto Rosà, Marco Tamba
PLOS Neglected Tropical Diseases: published January 2, 2020 | https://doi.org/10.1371/journal.pntd.0007953
Gene expression profiling of Trypanosoma cruzi in the presence of heme points to glycosomal metabolic adaptation of epimastigotes inside the vector
Marcia C. Paes, Francis M. S. Saraiva, Natália P. Nogueira, Carolina S. D. Vieira, Felipe A. Dias, Ana Rossini, Vitor Lima Coelho, Attilio Pane, Fei Sang, Marcos Alcocer
PLOS Neglected Tropical Diseases: published January 2, 2020 | https://doi.org/10.1371/journal.pntd.0007945
Lactococcus lactis expressing sand fly PpSP15 salivary protein confers long-term protection against Leishmania major in BALB/c mice
Elaheh Davarpanah, Negar Seyed, Fariborz Bahrami, Sima Rafati, Reza Safaralizadeh, Tahereh Taheri
PLOS Neglected Tropical Diseases: published January 3, 2020 | https://doi.org/10.1371/journal.pntd.0007939
A phase 1 randomized safety, reactogenicity, and immunogenicity study of Typhax: A novel protein capsular matrix vaccine candidate for the prevention of typhoid fever
Robert T. Cartee, Ann Thanawastien, Thomas J. Griffin IV, John J. Mekalanos, Stephan Bart, Kevin P. Killeen
PLOS Neglected Tropical Diseases: published January 6, 2020 | https://doi.org/10.1371/journal.pntd.0007912
The route of infection with Leptospira interrogans serovar Copenhageni affects the kinetics of bacterial dissemination and kidney colonization
Nisha Nair, Mariana Soares Guedes, Catherine Werts, Maria Gomes-Solecki
PLOS Neglected Tropical Diseases: published January 6, 2020 | https://doi.org/10.1371/journal.pntd.0007950
Development and Validation of a simple score for diagnosis of Leptospirosis at outpatient departments
Nidhikul Temeiam, Sutthi Jareinpituk, Phichayut Phinyo, Jayanton Patumanond, Nattachai Srisawat
PLOS Neglected Tropical Diseases: published January 9, 2020 | https://doi.org/10.1371/journal.pntd.0007977
Obesity impairs resistance to Leishmania major infection in C57BL/6 mice
Vinicius Dantas Martins, Franciele Carolina Silva, Felipe Caixeta, Matheus Batista Carneiro, Graziele Ribeiro Goes, Lícia Torres, Sara Cândida Barbosa, Leonardo Vaz, Nivea Carolina Paiva, Cláudia Martins Carneiro, Leda Quercia Vieira, Ana Maria Caetano Faria, Tatiani Uceli Maioli
PLOS Neglected Tropical Diseases: published January 10, 2020 | https://doi.org/10.1371/journal.pntd.0006596
Crystal structures of Triosephosphate Isomerases from Taenia solium and Schistosoma mansoni provide insights for vaccine rationale and drug design against helminth parasites
Pedro Jimenez-Sandoval, Eduardo Castro-Torres, Rogelio González-González, Corina Díaz-Quezada, Misraim Gurrola, Laura D. Camacho-Manriquez, Lucia Leyva-Navarro, Luis G. Brieba
PLOS Neglected Tropical Diseases: published January 10, 2020 | https://doi.org/10.1371/journal.pntd.0007815
Ivermectin as an adjuvant to anti-epileptic treatment in persons with onchocerciasis-associated epilepsy: A randomized proof-of-concept clinical trial
Michel Mandro, Joseph Nelson Siewe Fodjo, Deby Mukendi, Alfred Dusabimana, Sonia Menon, Steven Haesendonckx, Richard Lokonda, Swabra Nakato, Francoise Nyisi, Germain Abhafule, Deogratias Wonya’Rossi, Jean Marie Jakwong, Patrick Suykerbuyk, Jacques Meganck, An Hotterbeekx, Robert Colebunders
PLOS Neglected Tropical Diseases: published January 10, 2020 | https://doi.org/10.1371/journal.pntd.0007966
An observational prospective cohort study of the epidemiology of hospitalized patients with acute febrile illness in Indonesia
Muhammad Hussein Gasem, Herman Kosasih, Emiliana Tjitra, Bachti Alisjahbana, Muhammad Karyana, Dewi Lokida, Aaron Neal, C. Jason Liang, Abu Tholib Aman, Mansyur Arif, Pratiwi Sudarmono, Suharto, Tuti Parwati Merati, Vivi Lisdawati, Siswanto, Sophia Siddiqui, H. Clifford Lane, for INA-RESPOND
PLOS Neglected Tropical Diseases: published January 10, 2020 | https://doi.org/10.1371/journal.pntd.0007927
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Antileishmanial activity of Urtica dioica extract against zoonotic cutaneous leishmaniasis
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Patients help other patients: Qualitative study on a longstanding community cooperative to tackle leprosy in India
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PLOS Neglected Tropical Diseases: published January 13, 2020 | https://doi.org/10.1371/journal.pntd.0007984
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PLOS Neglected Tropical Diseases: published January 15, 2020 | https://doi.org/10.1371/journal.pntd.0007845
Systematic review of the effectiveness of selected drugs for preventive chemotherapy for Taenia solium taeniasis
Michelle M. Haby, Leopoldo A. Sosa Leon, Ana Luciañez, Ruben Santiago Nicholls, Ludovic Reveiz, Meritxell Donadeu
PLOS Neglected Tropical Diseases: published January 16, 2020 | https://doi.org/10.1371/journal.pntd.0007873
Under-detection of blood culture-positive enteric fever cases: The impact of missing data and methods for adjusting incidence estimates
Merryn Voysey, Dikshya Pant, Mila Shakya, Xinxue Liu, Rachel Colin-Jones, Katherine Theiss-Nyland, Nicola Smith, Shrijana Shrestha, Buddha Basnyat, Andrew J. Pollard, Virginia E. Pitzer
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PLOS Neglected Tropical Diseases: published January 17, 2020 | https://doi.org/10.1371/journal.pntd.0007965
Assessing the impact of aggregating disease stage data in model predictions of human African trypanosomiasis transmission and control activities in Bandundu province (DRC)
María Soledad Castaño, Martial L. Ndeffo-Mbah, Kat S. Rock, Cody Palmer, Edward Knock, Erick Mwamba Miaka, Joseph M. Ndung’u, Steve Torr, Paul Verlé, Simon E. F. Spencer, Alison Galvani, Caitlin Bever, Matt J. Keeling, Nakul Chitnis
PLOS Neglected Tropical Diseases: published January 21, 2020 | https://doi.org/10.1371/journal.pntd.0007976
Utility of primary cells to examine NPC1 receptor expression in Mops condylurus, a potential Ebola virus reservoir
Marcel Bokelmann, Kathryn Edenborough, Nicole Hetzelt, Petra Kreher, Angelika Lander, Andreas Nitsche, Uwe Vogel, Heinz Feldmann, Emmanuel Couacy-Hymann, Andreas Kurth
PLOS Neglected Tropical Diseases: published January 21, 2020 | https://doi.org/10.1371/journal.pntd.0007952
Oropouche virus cases identified in Ecuador using an optimised qRT-PCR informed by metagenomic sequencing
Emma L. Wise, Sully Márquez, Jack Mellors, Verónica Paz, Barry Atkinson, Bernardo Gutierrez, Sonia Zapata, Josefina Coloma, Oliver G. Pybus, Simon K. Jackson, Gabriel Trueba, Gyorgy Fejer, Christopher H. Logue, Steven T. Pullan
PLOS Neglected Tropical Diseases: published January 21, 2020 | https://doi.org/10.1371/journal.pntd.0007897
Crystal violet structural analogues identified by in silico drug repositioning present anti-Trypanosoma cruzi activity through inhibition of proline transporter TcAAAP069
Melisa Sayé, Lucrecia Gauna, Edward Valera-Vera, Chantal Reigada, Mariana R. Miranda, Claudio A. Pereira
PLOS Neglected Tropical Diseases: published January 21, 2020 | https://doi.org/10.1371/journal.pntd.0007481
Heatwaves and dengue outbreaks in Hanoi, Vietnam: New evidence on early warning
Jian Cheng, Hilary Bambrick, Laith Yakob, Gregor Devine, Francesca D. Frentiu, Do Thi Thanh Toan, Pham Quang Thai, Zhiwei Xu, Wenbiao Hu
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An investigation into the knowledge, perceptions and role of personal protective technologies in Zika prevention in Colombia
Carolina Mendoza, Gloria-Isabel Jaramillo, Thomas H. Ant, Grace M. Power, Robert T. Jones, Juliana Quintero, Neal Alexander, Jayne Webster, Lyda Osorio, James G. Logan
PLOS Neglected Tropical Diseases: published January 21, 2020 | https://doi.org/10.1371/journal.pntd.0007970
Rift Valley fever virus targets the maternal-foetal interface in ovine and human placentas
Judith Oymans, Paul J. Wichgers Schreur, Lucien van Keulen, Jet Kant, Jeroen Kortekaas
PLOS Neglected Tropical Diseases: published January 21, 2020 | https://doi.org/10.1371/journal.pntd.0007898
Hepatitis E as a cause of adult hospitalization in Bangladesh: Results from an acute jaundice surveillance study in six tertiary hospitals, 2014-2017
Repon C. Paul, Arifa Nazneen, Kajal C. Banik, Shariful Amin Sumon, Kishor K. Paul, Arifa Akram, M. Salim Uzzaman, Tahir Iqbal, Alexandra Tejada-Strop, Saleem Kamili, Stephen P. Luby, Heather F. Gidding, Andrew Hayen, Emily S. Gurley
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Test accuracy of polymerase chain reaction methods against conventional diagnostic techniques for Cutaneous Leishmaniasis (CL) in patients with clinical or epidemiological suspicion of CL: Systematic review and meta-analysis
Luz Estella Mesa, Rubén Manrique, Carlos Muskus, Sara M. Robledo
PLOS Neglected Tropical Diseases: published January 21, 2020 | https://doi.org/10.1371/journal.pntd.0007981
Pathological roles of MRP14 in anemia and splenomegaly during experimental visceral leishmaniasis
Kanna Ishizuka, Wataru Fujii, Natsuho Azuma, Haruka Mizobuchi, Ayako Morimoto, Chizu Sanjoba, Yoshitsugu Matsumoto, Yasuyuki Goto
PLOS Neglected Tropical Diseases: published January 21, 2020 | https://doi.org/10.1371/journal.pntd.0008020
Phylogenetic relationships and diversity of bat-associated Leptospira and the histopathological evaluation of these infections in bats from Grenada, West Indies
Amanda I. Bevans, Daniel M. Fitzpatrick, Diana M. Stone, Brian P. Butler, Maia P. Smith, Sonia Cheetham
PLOS Neglected Tropical Diseases: published January 21, 2020 | https://doi.org/10.1371/journal.pntd.0007940
Transcriptional analysis of THP-1 cells infected with Leishmania infantum indicates no activation of the inflammasome platform
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PLOS Neglected Tropical Diseases: published January 21, 2020 | https://doi.org/10.1371/journal.pntd.0007949
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PLOS Neglected Tropical Diseases: published January 21, 2020 | https://doi.org/10.1371/journal.pntd.0008021
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