C. sinensis adults were incubated with anti-Cs1 monoclonal antibody. A strong positive reaction was observed in the cells in a granulate, gland-like structure surrounding the acetabulum of C. sinensis adult worms, and a moderately positive reaction was seen in the outer tegument of the acetabulum. Cheng, Xu, et al. (2018)
Image Credit: Xue-Nian Xu, Na Cheng and Yan Zhou
Viewpoints
Precision mapping: An innovative tool and way forward to shrink the map, better target interventions, and accelerate toward the elimination of schistosomiasis
Louis-Albert Tchuem Tchuenté, J. Russell Stothard, David Rollinson, Jutta Reinhard-Rupp
PLOS Neglected Tropical Diseases: published August 2, 2018 | https://doi.org/10.1371/journal.pntd.0006563
The snail Biomphalaria glabrata as a model to interrogate the molecular basis of complex human diseases
Joanna M. Bridger, Paul J. Brindley, Matty Knight
PLOS Neglected Tropical Diseases: published August 9, 2018 | https://doi.org/10.1371/journal.pntd.0006552
Hajj, Umrah, and the neglected tropical diseases
Mashal M. Almutairi, Waleed Saleh Alsalem, Mazen Hassanain, Peter J. Hotez
PLOS Neglected Tropical Diseases: published August 16, 2018 | https://doi.org/10.1371/journal.pntd.0006539
The diverse roles of cysteine proteases in parasites and their suitability as drug targets
James H. McKerrow
PLOS Neglected Tropical Diseases: published August 23, 2018 | https://doi.org/10.1371/journal.pntd.0005639
Update on drug development targeting parasite cysteine proteases
James H. McKerrow
PLOS Neglected Tropical Diseases: published August 23, 2018 | https://doi.org/10.1371/journal.pntd.0005850
Policy Platform
Toward the 2020 goal of soil-transmitted helminthiasis control and elimination
Sören L. Becker, Harvy Joy Liwanag, Jedidiah S. Snyder, Oladele Akogun, Vicente Belizario. Jr, Matthew C. Freeman, Theresa W. Gyorkos, Rubina Imtiaz, Jennifer Keiser, Alejandro Krolewiecki, Bruno Levecke, Charles Mwandawiro, Rachel L. Pullan, David G. Addiss, Jürg Utzinger
PLOS Neglected Tropical Diseases: published August 14, 2018 | https://doi.org/10.1371/journal.pntd.0006606
From Innovation to Application
Rapid, inexpensive, fingerstick, whole-blood, sensitive, specific, point-of-care test for anti-Toxoplasma antibodies
Joseph Lykins, Xuan Li, Pauline Levigne, Ying Zhou, Kamal El Bissati, Fatima Clouser, Martine Wallon, Florence Morel, Karen Leahy, Bouchra El Mansouri, Maryam Siddiqui, Nicole Leong, Morgan Michalowski, Erin Irwin, Perpetua Goodall, Mahmoud Ismail, Monica Christmas, El Bachir Adlaoui, Mohamed Rhajaoui, Amina Barkat, Hua Cong, Ian J. Begeman, Bo Shiun Lai, Despina G. Contopoulos-Ioannidis, Jose G. Montoya, Yvonne Maldonado, Raymund Ramirez, Cindy Press, Francois Peyron, Rima McLeod
PLOS Neglected Tropical Diseases: published August 16, 2018 | https://doi.org/10.1371/journal.pntd.0006536
Symposium
Potential novel tick-borne Colpodella species parasite infection in patient with neurological symptoms
Jia-Fu Jiang, Rui-Ruo Jiang, Qiao-Cheng Chang, Yuan-Chun Zheng, Bao-Gui Jiang, Yi Sun, Na Jia, Ran Wei, Hong-Bo Liu, Qiu-Bo Huo, Hong Wang, Michael E. von Fricken, Wu-Chun Cao
PLOS Neglected Tropical Diseases: published August 2, 2018 | https://doi.org/10.1371/journal.pntd.0006546
Reviews
Cysteine proteases as digestive enzymes in parasitic helminths
Conor R. Caffrey, Louise Goupil, Karina M. Rebello, John P. Dalton, David Smith
PLOS Neglected Tropical Diseases: published August 23, 2018 | https://doi.org/10.1371/journal.pntd.0005840
Cysteine proteases during larval migration and development of helminths in their final host
Alexandra Grote, Conor R. Caffrey, Karina M. Rebello, David Smith, John P. Dalton, Sara Lustigman
PLOS Neglected Tropical Diseases: published August 23, 2018 | https://doi.org/10.1371/journal.pntd.0005919
Cysteine proteases in protozoan parasites
Jair L. Siqueira-Neto, Anjan Debnath, Laura-Isobel McCall, Jean A. Bernatchez, Momar Ndao, Sharon L. Reed, Philip J. Rosenthal
PLOS Neglected Tropical Diseases: published August 23, 2018 | https://doi.org/10.1371/journal.pntd.0006512
Research Articles
MyD88 activation in cardiomyocytes contributes to the heart immune response to acute Trypanosoma cruzi infection with no effect on local parasite control
Danni Yohani Santana, Rafael Moysés Salgado, Marina Fevereiro, Rogério Silva do Nascimento, Raissa Fonseca, Niels Olsen Saraiva Câmara, Sabrina Epiphanio, Cláudio Romero Farias Marinho, Maria Luiza Barreto-Chaves, Maria Regina D’ Império-Lima, José M. Álvarez
PLOS Neglected Tropical Diseases: published August 1, 2018 | https://doi.org/10.1371/journal.pntd.0006617
The importance of dog population contact network structures in rabies transmission
Mirjam Laager, Céline Mbilo, Enos Abdelaziz Madaye, Abakar Naminou, Monique Léchenne, Aurélie Tschopp, Service Kemdongarti Naïssengar, Timo Smieszek, Jakob Zinsstag, Nakul Chitnis
PLOS Neglected Tropical Diseases: published August 1, 2018 | https://doi.org/10.1371/journal.pntd.0006680
The impact of the Ebola virus disease (EVD) epidemic on agricultural production and livelihoods in Liberia
Tsegaye T. Gatiso, Isabel Ordaz-Németh, Trokon Grimes, Menladi Lormie, Clement Tweh, Hjalmar S. Kühl, Jessica Junker
PLOS Neglected Tropical Diseases: published August 2, 2018 | https://doi.org/10.1371/journal.pntd.0006580
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