Controlled exsheathment of axenic Necator americanus L3 larvae was harnessed to prepare partially exsheathed hookworms, which were analysed using Atomic Force Microscopy (AFM) and Time-of-Flight Secondary Ion Mass Spectrometry (ToF-SIMS). AFM revealed previously unseen surface area enhancing nano-annuli exclusive to the sheath surface. ToF-SIMS elucidated unique and significantly different chemistries between the surface of the emergent cuticle (lubricating phosphatidylglycerol-like-head groups, red) and deposited sheath (immunogenic heparan sulphate-like-monosaccharides, green). Chauhan et al.
Image Credit: Dr Veeren M Chauhan
Editorial
Ten failings in global neglected tropical diseases control
Peter J. Hotez
PLOS Neglected Tropical Diseases: published December 21, 2017 | https://doi.org/10.1371/journal.pntd.0005896
Policy Platform
Sustaining visceral leishmaniasis elimination in Bangladesh – Could a policy brief help?
Alyssa Fitzpatrick, Noor Saad M. S. Al-Kobaisi, Jessica Beitman Maya, Yu Ren Chung, Satyender Duhan, Erdene Elbegdorj, Sushant Jain, Edward Kuhn, Alexandra Nastase, Be-Nazir Ahmed, Piero Olliaro
PLOS Neglected Tropical Diseases: published December 12, 2017 | https://doi.org/10.1371/journal.pntd.0006081
Symposiums
Case report: A rare case of urinary myiasis induced by the fourth instar larvae of Telmatoscopus albipunctatus
Beibei Zhang, Lifu Wang, Jiahua Liu, Lian Xu, Langui Song, Xiaoying Wu, Xi Sun, Zhongdao Wu
PLOS Neglected Tropical Diseases: published December 7, 2017 | https://doi.org/10.1371/journal.pntd.0006016
Emergence of melioidosis in the Indian Ocean region: Two new cases and a literature review
Nicolas Allou, Olivier Martinet, Jérôme Allyn, Bruno Bouchet, Marie-Christine Jaffar-Bandjee, Thomas Galas, Nicolas Traversier, Olivier Belmonte
PLOS Neglected Tropical Diseases: published December 14, 2017 | https://doi.org/10.1371/journal.pntd.0006018
Review
Drug resistance and treatment failure in leishmaniasis: A 21st century challenge
Alicia Ponte-Sucre, Francisco Gamarro, Jean-Claude Dujardin, Michael P. Barrett, Rogelio López-Vélez, Raquel García-Hernández, Andrew W. Pountain, Roy Mwenechanya, Barbara Papadopoulou
PLOS Neglected Tropical Diseases: published December 14, 2017 | https://doi.org/10.1371/journal.pntd.0006052
Research Articles
A temporal comparison of sex-aggregation pheromone gland content and dynamics of release in three members of the Lutzomyia longipalpis (Diptera: Psychodidae) species complex
Mikel A. González, Krishna K. Bandi, Melissa J. Bell, Reginaldo P. Brazil, Erin Dilger, Angel Guerrero, Orin Courtenay, James G. C. Hamilton
PLOS Neglected Tropical Diseases: published December 1, 2017 | https://doi.org/10.1371/journal.pntd.0006071
Review of the factors influencing the motivation of community drug distributors towards the control and elimination of neglected tropical diseases (NTDs)
Alison Krentel, Margaret Gyapong, Shruti Mallya, Nana Yaa Boadu, Mary Amuyunzu-Nyamongo, Mariana Stephens, Deborah A. McFarland
PLOS Neglected Tropical Diseases: published December 6, 2017 | https://doi.org/10.1371/journal.pntd.0006065
Symptoms associated with adverse dengue fever prognoses at the time of reporting in the 2015 dengue outbreak in Taiwan
Chun-Yin Yeh, Po-Lin Chen, Kun-Ta Chuang, Yu-Chen Shu, Yu-Wen Chien, Guey Chuen Perng, Wen-Chien Ko, Nai-Ying Ko
PLOS Neglected Tropical Diseases: published December 6, 2017 | https://doi.org/10.1371/journal.pntd.0006091
Body size and hosts of Triatoma infestans populations affect the size of bloodmeal contents and female fecundity in rural northwestern Argentina
Ricardo E. Gürtler, María del Pilar Fernández, María Carla Cecere, Joel E. Cohen
PLOS Neglected Tropical Diseases: published December 6, 2017 | https://doi.org/10.1371/journal.pntd.0006097
The physicochemical fingerprint of Necator americanus
Veeren M. Chauhan, David J. Scurr, Thomas Christie, Gary Telford, Jonathan W. Aylott, David I. Pritchard
PLOS Neglected Tropical Diseases: published December 7, 2017 | https://doi.org/10.1371/journal.pntd.0005971
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Michelle N. Clements, Christl A. Donnelly, Alan Fenwick, Narcis B. Kabatereine, Sarah C. L. Knowles, Aboulaye Meité, Eliézer K. N'Goran, Yolisa Nalule, Sarah Nogaro, Anna E. Phillips, Edridah Muheki Tukahebwa, Fiona M. Fleming
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Low cost, low tech SNP genotyping tools for resource-limited areas: Plague in Madagascar as a model
Cedar L. Mitchell, Voahangy Andrianaivoarimanana, Rebecca E. Colman, Joseph Busch, Heidie Hornstra-O’Neill, Paul S. Keim, David M. Wagner, Minoarisoa Rajerison, Dawn N. Birdsell
PLOS Neglected Tropical Diseases: published December 11, 2017 | https://doi.org/10.1371/journal.pntd.0006077
Longitudinal assessment of anti-PGL-I serology in contacts of leprosy patients in Bangladesh
Renate A. Richardus, Konrad van der Zwet, Anouk van Hooij, Louis Wilson, Linda Oskam, Roel Faber, Susan J. F. van den Eeden, David Pahan, Khorshed Alam, Jan Hendrik Richardus, Annemieke Geluk
PLOS Neglected Tropical Diseases: published December 11, 2017 | https://doi.org/10.1371/journal.pntd.0006083
Characterization of the Giardia intestinalis secretome during interaction with human intestinal epithelial cells: The impact on host cells
Showgy Y. Ma’ayeh, Jingyi Liu, Dimitra Peirasmaki, Katarina Hörnaeus, Sara Bergström Lind, Manfred Grabherr, Jonas Bergquist, Staffan G. Svärd
PLOS Neglected Tropical Diseases: published December 11, 2017 | https://doi.org/10.1371/journal.pntd.0006120
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Jacob T. Cox, Harran Mkocha, Beatriz Munoz, Sheila K. West
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Oscar Debrah, Ernest O. Mensah, Laura Senyonjo, Dziedzom K. de Souza, Tei E. Hervie, David Agyemang, Didier Bakajika, Benjamin Marfo, Felix Ahorsu, Seth Wanye, Robin Bailey, Joseph B. Koroma, Agatha Aboe, Nana-Kwadwo Biritwum
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Arun Anandanarayanan, Opinder Krishen Raina, Hniang Lalrinkima, Ajayta Rialch, Muthu Sankar, Anju Varghese
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Virulence, pathology, and pathogenesis of Pteropine orthoreovirus (PRV) in BALB/c mice: Development of an animal infection model for PRV
Kazutaka Egawa, Masayuki Shimojima, Satoshi Taniguchi, Noriyo Nagata, Hideki Tani, Tomoki Yoshikawa, Takeshi Kurosu, Shumpei Watanabe, Shuetsu Fukushi, Masayuki Saijo
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Polypyridylruthenium(II) complexes exert anti-schistosome activity and inhibit parasite acetylcholinesterases
Madhu K. Sundaraneedi, Bemnet A. Tedla, Ramon M. Eichenberger, Luke Becker, Darren Pickering, Michael J. Smout, Siji Rajan, Phurpa Wangchuk, F. Richard Keene, Alex Loukas, J. Grant Collins, Mark S. Pearson
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Genotyping of Mycobacterium leprae for better understanding of leprosy transmission in Fortaleza, Northeastern Brazil
Amanda N. B. Fontes, Luana N. G. C. Lima, Rosa M. S. Mota, Rosa L. F. Almeida, Maria A. Pontes, Heitor de S. Gonçalves, Cristiane C. Frota, Varalakshmi D. Vissa, Patrick J. Brennan, Ricardo J. P. S. Guimaraes, Carl Kendall, Ligia R. F. S. Kerr, Philip N. Suffys
PLOS Neglected Tropical Diseases: published December 15, 2017 | https://doi.org/10.1371/journal.pntd.0006117
Analysis of the efficacy of Taiwanese freeze-dried neurotoxic antivenom against Naja kaouthia, Naja siamensis and Ophiophagus hannah through proteomics and animal model approaches
Chien-Chun Liu, Chen-Hsien You, Po-Jung Wang, Jau-Song Yu, Guo-Jen Huang, Chien-Hsin Liu, Wen-Chin Hsieh, Chih-Chuan Lin
PLOS Neglected Tropical Diseases: published December 15, 2017 | https://doi.org/10.1371/journal.pntd.0006138
Increased activated memory B-cells in the peripheral blood of patients with erythema nodosum leprosum reactions
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PLOS Neglected Tropical Diseases: published December 18, 2017 | https://doi.org/10.1371/journal.pntd.0006121
Host immunity, nutrition and coinfection alter longitudinal infection patterns of schistosomes in a free ranging African buffalo population
Brianna R. Beechler, Anna E. Jolles, Sarah A. Budischak, Paul L. A. M. Corstjens, Vanessa O. Ezenwa, Mireya Smith, Robert S. Spaan, Govert J. van Dam, Michelle L. Steinauer
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Human Neutrophil Peptide 1 as immunotherapeutic agent against Leishmania infected BALB/c mice
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Juan C. Ramírez, Carolina Torres, María de los A. Curto, Alejandro G. Schijman
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PLOS Neglected Tropical Diseases: published December 19, 2017 | https://doi.org/10.1371/journal.pntd.0006149
Individual co-variation between viral RNA load and gene expression reveals novel host factors during early dengue virus infection of the Aedes aegypti midgut
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Corrections
Correction: CD8+ T cells provide immune protection against murine disseminated endotheliotropic Orientia tsutsugamushi infection
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