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Aedes aegypti adult overies (post-blood) are shown. The tissue is labeled with phalloidin (red) and counterstained with the nuclear stain TO-PRO (blue), revealing the structural details of ovary organization. Duman-Scheel et al.
Image Credit: Keshava Mysore
Editorial
Impact of the Neglected Tropical Diseases on Human Development in the Organisation of Islamic Cooperation Nations
Peter J. Hotez, Jennifer R. Herricks
PLOS Neglected Tropical Diseases: published November 25, 2015 | https://doi.org/10.1371/journal.pntd.0003782
Viewpoints
Generating Evidence to Improve the Response to Neglected Diseases: How Operational Research in a Médecins Sans Frontières Buruli Ulcer Treatment Programme Informed International Management Guidance
Daniel P. O’Brien, Nathan Ford, Marco Vitoria, Kingsley Asiedu, Alexandra Calmy, Philipp Du Cros, Eric Comte, Vanessa Christinet
PLOS Neglected Tropical Diseases: published November 12, 2015 | https://doi.org/10.1371/journal.pntd.0004075
Historical Profiles and Perspectives
Bihar’s Pioneering School-Based Deworming Programme: Lessons Learned in Deworming over 17 Million Indian School-Age Children in One Sustainable Campaign
Lesley J. Drake, Sarman Singh, C. K. Mishra, Amarjeet Sinha, Sanjay Kumar, Rajesh Bhushan, T. Deirdre Hollingsworth, Laura J. Appleby, Rakesh Kumar, Kriti Sharma, Yogita Kumar, Sri Raman, Stalin Chakrabarty, Jimmy H. Kihara, N. K. Gunawardena, Grace Hollister, Vandana Kumar, Anish Ankur, Babul Prasad, Sushma Ramachandran, Alissa Fishbane, Prerna Makkar
PLOS Neglected Tropical Diseases: published November 19, 2015 | https://doi.org/10.1371/journal.pntd.0004106
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Symposiums
Complete Healing of a Laboratory-Confirmed Buruli Ulcer Lesion after Receiving Only Herbal Household Remedies
Arianna Andreoli, Ferdinand Mou, Jacques C. Minyem, Fidèle G. Wantong, Djeunga Noumen, Paschal K. Awah, Gerd Pluschke, Alphonse Um Boock, Martin W. Bratschi
PLOS Neglected Tropical Diseases: published November 25, 2015 | https://doi.org/10.1371/journal.pntd.0004102
Arthropod Vectors and Disease Transmission: Translational Aspects
Wolfgang W. Leitner, Tonu Wali, Randall Kincaid, Adriana Costero-Saint Denis
PLOS Neglected Tropical Diseases: published November 19, 2015 | https://doi.org/10.1371/journal.pntd.0004107
A Case of Urogenital Human Schistosomiasis from a Non-endemic Area
Antonia Calvo-Cano, Lieselotte Cnops, Tine Huyse, Lisette van Lieshout, Josefina Pardos, M. E. Valls, Agustín Franco, David Rollinson, Joaquim Gascon
PLOS Neglected Tropical Diseases: published November 5, 2015 | https://doi.org/10.1371/journal.pntd.0004053
Reviews
A Re-Examination of the History of Etiologic Confusion between Dengue and Chikungunya
Goro Kuno
PLOS Neglected Tropical Diseases: published November 12, 2015 | https://doi.org/10.1371/journal.pntd.0004101
Historical Perspectives on the Epidemiology of Human Chagas Disease in Texas and Recommendations for Enhanced Understanding of Clinical Chagas Disease in the Southern United States
Melissa N. Garcia, Laila Woc-Colburn, David Aguilar, Peter J. Hotez, Kristy O. Murray
PLOS Neglected Tropical Diseases: published November 5, 2015 | https://doi.org/10.1371/journal.pntd.0003981
Research Articles
A Genomic Approach to Resolving Relapse versus Reinfection among Four Cases of Buruli Ulcer
Miriam Eddyani, Koen Vandelannoote, Conor J. Meehan, Sabin Bhuju, Jessica L. Porter, Julia Aguiar, Torsten Seemann, Michael Jarek, Mahavir Singh, Françoise Portaels, Timothy P. Stinear, Bouke C. de Jong
PLOS Neglected Tropical Diseases: published November 30, 2015 | https://doi.org/10.1371/journal.pntd.0004158
Exploring Consumer Perceptions and Economic Burden of Onchocerciasis on Households in Enugu State, South-East Nigeria
Ogochukwu Ibe, Obinna Onwujekwe, Benjamin Uzochukwu, Miriam Ajuba, Paul Okonkwo
PLOS Neglected Tropical Diseases: published November 30, 2015 | https://doi.org/10.1371/journal.pntd.0004231
The Molecular Epidemiology and Evolution of Murray Valley Encephalitis Virus: Recent Emergence of Distinct Sub-lineages of the Dominant Genotype 1
David T. Williams, Sinéad M. Diviney, Aziz-ur-Rahman Niazi, Peter A. Durr, Beng Hooi Chua, Belinda Herring, Alyssa Pyke, Stephen L. Doggett, Cheryl A. Johansen, John S. Mackenzie
PLOS Neglected Tropical Diseases: published November 24, 2015 | https://doi.org/10.1371/journal.pntd.0004240
Establishment of a Canine Rabies Burden in Haiti through the Implementation of a Novel Surveillance Program
Ryan M Wallace, Hannah Reses, Richard Franka, Pierre Dilius, Natael Fenelon, Lillian Orciari, Melissa Etheart, Apollon Destine, Kelly Crowdis, Jesse D Blanton, Calvin Francisco, Fleurinord Ludder, Victor Del Rio Vilas, Joseph Haim, Max Millien
PLOS Neglected Tropical Diseases: published November 24, 2015 | https://doi.org/10.1371/journal.pntd.0004245
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Trachoma and Relative Poverty: A Case-Control Study
Esmael Habtamu, Tariku Wondie, Sintayehu Aweke, Zerihun Tadesse, Mulat Zerihun, Zebideru Zewdie, Kelly Callahan, Paul M. Emerson, Hannah Kuper, Robin L. Bailey, David C. W. Mabey, Saul N. Rajak, Sarah Polack, Helen A. Weiss, Matthew J. Burton
PLOS Neglected Tropical Diseases: published November 23, 2015 | https://doi.org/10.1371/journal.pntd.0004228
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The Impact of Trachomatous Trichiasis on Quality of Life: A Case Control Study
Esmael Habtamu, Tariku Wondie, Sintayehu Aweke, Zerihun Tadesse, Mulat Zerihun, Zebideru Zewudie, Wondimu Gebeyehu, Kelly Callahan, Paul M. Emerson, Hannah Kuper, Robin L. Bailey, David C. W. Mabey, Saul N. Rajak, Sarah Polack, Helen A. Weiss, Matthew J. Burton
PLOS Neglected Tropical Diseases: published November 23, 2015 | https://doi.org/10.1371/journal.pntd.0004254
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Quality of Reporting and Adherence to ARRIVE Guidelines in Animal Studies for Chagas Disease Preclinical Drug Research: A Systematic Review
Julián Ernesto Nicolás Gulin, Daniela Marisa Rocco, Facundo García-Bournissen
PLOS Neglected Tropical Diseases: published November 20, 2015 | https://doi.org/10.1371/journal.pntd.0004194
Modeling and Validation of Environmental Suitability for Schistosomiasis Transmission Using Remote Sensing
Yvonne Walz, Martin Wegmann, Stefan Dech, Penelope Vounatsou, Jean-Noël Poda, Eliézer K. N'Goran, Jürg Utzinger, Giovanna Raso
PLOS Neglected Tropical Diseases: published November 20, 2015 | https://doi.org/10.1371/journal.pntd.0004217
Plasmodium vivax Transmission in Africa
Rosalind E. Howes, Robert C. Reiner Jr., Katherine E. Battle, Joshua Longbottom, Bonnie Mappin, Dariya Ordanovich, Andrew J. Tatem, Chris Drakeley, Peter W. Gething, Peter A. Zimmerman, David L. Smith, Simon I. Hay
PLOS Neglected Tropical Diseases: published November 20, 2015 | https://doi.org/10.1371/journal.pntd.0004222
Deltamethrin Resistance Mechanisms in Aedes aegypti Populations from Three French Overseas Territories Worldwide
Isabelle Dusfour, Pilar Zorrilla, Amandine Guidez, Jean Issaly, Romain Girod, Laurent Guillaumot, Carlos Robello, Clare Strode
PLOS Neglected Tropical Diseases: published November 20, 2015 | https://doi.org/10.1371/journal.pntd.0004226
Shaking the Tree: Multi-locus Sequence Typing Usurps Current Onchocercid (Filarial Nematode) Phylogeny
Emilie Lefoulon, Odile Bain, Jérôme Bourret, Kerstin Junker, Ricardo Guerrero, Israel Cañizales, Yuriy Kuzmin, Tri Baskoro T. Satoto, Jorge Manuel Cardenas-Callirgos, Sueli de Souza Lima, Christian Raccurt, Yasen Mutafchiev, Laurent Gavotte, Coralie Martin
PLOS Neglected Tropical Diseases: published November 20, 2015 | https://doi.org/10.1371/journal.pntd.0004233
Prevalence of and Factors Associated with Human Cysticercosis in 60 Villages in Three Provinces of Burkina Faso
Hélène Carabin, Athanase Millogo, Assana Cissé, Sarah Gabriël, Ida Sahlu, Pierre Dorny, Cici Bauer, Zekiba Tarnagda, Linda D Cowan, Rasmané Ganaba
PLOS Neglected Tropical Diseases: published November 20, 2015 | https://doi.org/10.1371/journal.pntd.0004248
Prevention of Malaria Resurgence in Greece through the Association of Mass Drug Administration (MDA) to Immigrants from Malaria-Endemic Regions and Standard Control Measures
Maria Tseroni, Agoritsa Baka, Christina Kapizioni, Georges Snounou, Sotirios Tsiodras, Maria Charvalakou, Maria Georgitsou, Maria Panoutsakou, Ioanna Psinaki, Maria Tsoromokou, George Karakitsos, Danai Pervanidou, Annita Vakali, Varvara Mouchtouri, Theano Georgakopoulou, Zissis Mamuris, Nikos Papadopoulos, George Koliopoulos, Evangelos Badieritakis, Vasilis Diamantopoulos, Athanasios Tsakris, Jenny Kremastinou, Christos Hadjichristodoulou, MALWEST Project
PLOS Neglected Tropical Diseases: published November 19, 2015 | https://doi.org/10.1371/journal.pntd.0004215
Comparative Genomics of Field Isolates of Mycobacterium bovis and M. caprae Provides Evidence for Possible Correlates with Bacterial Viability and Virulence
José de la Fuente, Iratxe Díez-Delgado, Marinela Contreras, Joaquín Vicente, Alejandro Cabezas-Cruz, Raquel Tobes, Marina Manrique, Vladimir López, Beatriz Romero, Javier Bezos, Lucas Dominguez, Iker A. Sevilla, Joseba M. Garrido, Ramón Juste, Guillermo Madico, Edward Jones-López, Christian Gortazar
PLOS Neglected Tropical Diseases: published November 19, 2015 | https://doi.org/10.1371/journal.pntd.0004232
Simple, Rapid Mycobacterium ulcerans Disease Diagnosis from Clinical Samples by Fluorescence of Mycolactone on Thin Layer Chromatography
Anita Wadagni, Michael Frimpong, Delphin Mavinga Phanzu, Anthony Ablordey, Emmanuel Kacou, Mirabelle Gbedevi, Estelle Marion, Yalan Xing, Vaddela Sudheer Babu, Richard Odame Phillips, Mark Wansbrough-Jones, Yoshito Kishi, Kingsley Asiedu
PLOS Neglected Tropical Diseases: published November 19, 2015 | https://doi.org/10.1371/journal.pntd.0004247
Molecular Characterisation of Chikungunya Virus Infections in Trinidad and Comparison of Clinical and Laboratory Features with Dengue and Other Acute Febrile Cases
Nikita Sahadeo, Hamish Mohammed, Orchid M. Allicock, Albert J. Auguste, Steven G. Widen, Kimberly Badal, Krishna Pulchan, Jerome E. Foster, Scott C. Weaver, Christine V. F. Carrington
PLOS Neglected Tropical Diseases: published November 18, 2015 | https://doi.org/10.1371/journal.pntd.0004199
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Distribution and Potential Indicators of Hospitalized Cases of Neurocysticercosis and Epilepsy in Ecuador from 1996 to 2008
Lenin Ron-Garrido, Marco Coral-Almeida, Sarah Gabriël, Washington Benitez-Ortiz, Claude Saegerman, Pierre Dorny, Dirk Berkvens, Emmanuel Nji Abatih
PLOS Neglected Tropical Diseases: published November 18, 2015 | https://doi.org/10.1371/journal.pntd.0004236
Polyfunctional Specific Response to Echinococcus Granulosus Associates to the Biological Activity of the Cysts
Linda Petrone, Valentina Vanini, Elisa Petruccioli, Giuseppe Maria Ettorre, Vincenzo Schininà, Elisa Busi Rizzi, Alessandra Ludovisi, Angela Corpolongo, Giuseppe Ippolito, Edoardo Pozio, Antonella Teggi, Delia Goletti
PLOS Neglected Tropical Diseases: published November 17, 2015 | https://doi.org/10.1371/journal.pntd.0004209
Validation of qPCR Methods for the Detection of Mycobacterium in New World Animal Reservoirs
Genevieve Housman, Joanna Malukiewicz, Vanner Boere, Adriana D. Grativol, Luiz Cezar M. Pereira, Ita de Oliveira e Silva, Carlos R. Ruiz-Miranda, Richard Truman, Anne C. Stone
PLOS Neglected Tropical Diseases: published November 16, 2015 | https://doi.org/10.1371/journal.pntd.0004198
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Proteasome Inhibition Suppresses Dengue Virus Egress in Antibody Dependent Infection
Milly M. Choy, Summer L. Zhang, Vivian V. Costa, Hwee Cheng Tan, Sophie Horrevorts, Eng Eong Ooi
PLOS Neglected Tropical Diseases: published November 13, 2015 | https://doi.org/10.1371/journal.pntd.0004058
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Molecular Characterization of a Novel Family of Trypanosoma cruzi Surface Membrane Proteins (TcSMP) Involved in Mammalian Host Cell Invasion
Nadini Oliveira Martins, Renata Torres de Souza, Esteban Mauricio Cordero, Danielle Cortez Maldonado, Cristian Cortez, Marjorie Mendes Marini, Eden Ramalho Ferreira, Ethel Bayer-Santos, Igor Correia de Almeida, Nobuko Yoshida, José Franco da Silveira
PLOS Neglected Tropical Diseases: published November 13, 2015 | https://doi.org/10.1371/journal.pntd.0004216
Recombinant Envelope-Proteins with Mutations in the Conserved Fusion Loop Allow Specific Serological Diagnosis of Dengue-Infections
Alexandra Rockstroh, Luisa Barzon, Monia Pacenti, Giorgio Palù, Matthias Niedrig, Sebastian Ulbert
PLOS Neglected Tropical Diseases: published November 13, 2015 | https://doi.org/10.1371/journal.pntd.0004218
Loop-Mediated Isothermal Amplification for Laboratory Confirmation of Buruli Ulcer Disease—Towards a Point-of-Care Test
Marcus Beissner, Richard Odame Phillips, Florian Battke, Malkin Bauer, Kossi Badziklou, Fred Stephen Sarfo, Issaka Maman, Agata Rhomberg, Ebekalisai Piten, Michael Frimpong, Kristina Lydia Huber, Dominik Symank, Moritz Jansson, Franz Xaver Wiedemann, Abiba Banla Kere, Karl-Heinz Herbinger, Thomas Löscher, Gisela Bretzel
PLOS Neglected Tropical Diseases: published November 13, 2015 | https://doi.org/10.1371/journal.pntd.0004219
Production of Infectious Dengue Virus in Aedes aegypti Is Dependent on the Ubiquitin Proteasome Pathway
Milly M. Choy, October M. Sessions, Duane J. Gubler, Eng Eong Ooi
PLOS Neglected Tropical Diseases: published November 13, 2015 | https://doi.org/10.1371/journal.pntd.0004227
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Knowledge, Attitudes and Practices (KAP) on Rift Valley Fever among Pastoralist Communities of Ijara District, North Eastern Kenya
Ismail H. Abdi, Hippolyte D. Affognon, Anthony K. Wanjoya, Washington Onyango-Ouma, Rosemary Sang
PLOS Neglected Tropical Diseases: published November 13, 2015 | https://doi.org/10.1371/journal.pntd.0004239
Leptospirosis in Rio Grande do Sul, Brazil: An Ecosystem Approach in the Animal-Human Interface
Maria Cristina Schneider, Patricia Najera, Martha M. Pereira, Gustavo Machado, Celso B. dos Anjos, Rogério O. Rodrigues, Gabriela M. Cavagni, Claudia Muñoz-Zanzi, Luis G. Corbellini, Mariana Leone, Daniel F. Buss, Sylvain Aldighieri, Marcos A. Espinal
PLOS Neglected Tropical Diseases: published November 12, 2015 | https://doi.org/10.1371/journal.pntd.0004095
Vibrio cholerae Serogroup O139: Isolation from Cholera Patients and Asymptomatic Household Family Members in Bangladesh between 2013 and 2014
Fahima Chowdhury, Alison E. Mather, Yasmin Ara Begum, Muhammad Asaduzzaman, Nabilah Baby, Salma Sharmin, Rajib Biswas, Muhammad Ikhtear Uddin, Regina C. LaRocque, Jason B. Harris, Stephen B. Calderwood, Edward T. Ryan, John D. Clemens, Nicholas R. Thomson, Firdausi Qadri
PLOS Neglected Tropical Diseases: published November 12, 2015 | https://doi.org/10.1371/journal.pntd.0004183
Quality of Sterile Male Tsetse after Long Distance Transport as Chilled, Irradiated Pupae
Momar Talla Seck, Soumaïla Pagabeleguem, Mireille D. Bassene, Assane Gueye Fall, Thérèse A. R. Diouf, Baba Sall, Marc J. B. Vreysen, Jean-Baptiste Rayaissé, Peter Takac, Issa Sidibé, Andrew G. Parker, Gratian N. Mutika, Jérémy Bouyer, Geoffrey Gimonneau
PLOS Neglected Tropical Diseases: published November 12, 2015 | https://doi.org/10.1371/journal.pntd.0004229
Dispersal of Engineered Male Aedes aegypti Mosquitoes
Peter Winskill, Danilo O. Carvalho, Margareth L. Capurro, Luke Alphey, Christl A. Donnelly, Andrew R. McKemey
PLOS Neglected Tropical Diseases: published November 10, 2015 | https://doi.org/10.1371/journal.pntd.0004156
Parasitological, Hematological and Biochemical Characteristics of a Model of Hyper-microfilariaemic Loiasis (Loa loa) in the Baboon (Papio anubis)
Samuel Wanji, Ebanga-Echi Eyong, Nicholas Tendongfor, Che Ngwa, Elive Esuka, Arnaud Kengne-Ouafo, Fabrice Datchoua-Poutcheu, Peter Enyong, Adrian Hopkins, Charles D. Mackenzie
PLOS Neglected Tropical Diseases: published November 10, 2015 | https://doi.org/10.1371/journal.pntd.0004202
Distribution of Plasmids in Distinct Leptospira Pathogenic Species
Yanzhuo Wang, Xuran Zhuang, Yi Zhong, Cuicai Zhang, Yan Zhang, Lingbing Zeng, Yongzhang Zhu, Ping He, Ke Dong, Utpal Pal, Xiaokui Guo, Jinhong Qin
PLOS Neglected Tropical Diseases: published November 10, 2015 | https://doi.org/10.1371/journal.pntd.0004220
Population Dynamics of Owned, Free-Roaming Dogs: Implications for Rabies Control
Anne Conan, Oluyemisi Akerele, Greg Simpson, Bjorn Reininghaus, Jacques van Rooyen, Darryn Knobel
PLOS Neglected Tropical Diseases: published November 6, 2015 | https://doi.org/10.1371/journal.pntd.0004177
Cross-Reactivity of Filariais ICT Cards in Areas of Contrasting Endemicity of Loa loa and Mansonella perstans in Cameroon: Implications for Shrinking of the Lymphatic Filariasis Map in the Central African Region
Samuel Wanji, Nathalie Amvongo-Adjia, Benjamin Koudou, Abdel Jelil Njouendou, Patrick W. Chounna Ndongmo, Jonas A. Kengne-Ouafo, Fabrice R. Datchoua-Poutcheu, Bridget Adzemye Fovennso, Dizzle Bita Tayong, Fanny Fri Fombad, Peter U. Fischer, Peter I. Enyong, Moses Bockarie
PLOS Neglected Tropical Diseases: published November 6, 2015 | https://doi.org/10.1371/journal.pntd.0004184
Determinants of Visceral Leishmaniasis: A Case-Control Study in Gedaref State, Sudan
Fabienne Nackers, Yolanda Kathrin Mueller, Niven Salih, Mousab Siddig Elhag, Mobarak Elnour Elbadawi, Omer Hammam, Ann Mumina, Atia Abdalla Atia, Jean-François Etard, Koert Ritmeijer, François Chappuis
PLOS Neglected Tropical Diseases: published November 6, 2015 | https://doi.org/10.1371/journal.pntd.0004187
The Role of Child Health Days in the Attainment of Global Deworming Coverage Targets among Preschool-Age Children
Richard Senam Kumapley, Roland Kupka, Nita Dalmiya
PLOS Neglected Tropical Diseases: published November 6, 2015 | https://doi.org/10.1371/journal.pntd.0004206
siRNA-Mediated Silencing of doublesex during Female Development of the Dengue Vector Mosquito Aedes aegypti
Keshava Mysore, Longhua Sun, Michael Tomchaney, Gwyneth Sullivan, Haley Adams, Andres S. Piscoya, David W. Severson, Zainulabeuddin Syed, Molly Duman-Scheel
PLOS Neglected Tropical Diseases: published November 6, 2015 | https://doi.org/10.1371/journal.pntd.0004213
Mass Administration of Ivermectin for the Elimination of Onchocerciasis Significantly Reduced and Maintained Low the Prevalence of Strongyloides stercoralis in Esmeraldas, Ecuador
Mariella Anselmi, Dora Buonfrate, Angel Guevara Espinoza, Rosanna Prandi, Monica Marquez, Maria Gobbo, Antonio Montresor, Marco Albonico, Marcia Racines Orbe, Juan Martin Moreira, Zeno Bisoffi
PLOS Neglected Tropical Diseases: published November 5, 2015 | https://doi.org/10.1371/journal.pntd.0004150
Shrinking the Lymphatic Filariasis Map of Ethiopia: Reassessing the Population at Risk through Nationwide Mapping
Maria P. Rebollo, Heven Sime, Ashenafi Assefa, Jorge Cano, Kebede Deribe, Alba Gonzalez-Escalada, Oumer Shafi, Gail Davey, Simon J. Brooker, Amha Kebede, Moses J. Bockarie
PLOS Neglected Tropical Diseases: published November 5, 2015 | https://doi.org/10.1371/journal.pntd.0004172
Multiple Origins of Mutations in the mdr1 Gene—A Putative Marker of Chloroquine Resistance in P. vivax
Mette L. Schousboe, Samir Ranjitkar, Rupika S. Rajakaruna, Priyanie H. Amerasinghe, Francisco Morales, Richard Pearce, Rosalyn Ord, Toby Leslie, Mark Rowland, Nahla B. Gadalla, Flemming Konradsen, Ib C. Bygbjerg, Cally Roper, Michael Alifrangis
PLOS Neglected Tropical Diseases: published November 5, 2015 | https://doi.org/10.1371/journal.pntd.0004196
Depletion of UDP-Glucose and UDP-Galactose Using a Degron System Leads to Growth Cessation of Leishmania major
Sebastian Damerow, Carolin Hoppe, Giulia Bandini, Patricia Zarnovican, Falk R. Buettner, Carsten G. K. Lüder, Michael A. J. Ferguson, Françoise H. Routier
PLOS Neglected Tropical Diseases: published November 3, 2015 | https://doi.org/10.1371/journal.pntd.0004205
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Medical Student Knowledge of Neglected Tropical Diseases in Peru: A Cross-Sectional Study
Renato A. Errea, George Vasquez-Rios, Jorge D. Machicado, Maria Susana Gallardo, Marilhia Cornejo, Jorge F. Urquiaga, Diego Montoya, Rodrigo Zamudio, Angelica Terashima, Luis A. Marcos, Frine Samalvides
PLOS Neglected Tropical Diseases: published November 2, 2015 | https://doi.org/10.1371/journal.pntd.0004197