April 2014

Cover

A pregnant female tsetse fly (Glossina morsitans).

Issue Image

The focus of the tsetse genome project. See the Tsetse Genome Biology Collection.

Image Credit: Geoffrey M. Attardo, Research Scientist at the Yale School of Public Health

Editorial

Human African Trypanosomiasis Research Gets a Boost: Unraveling the Tsetse Genome

Serap Aksoy, Geoffrey Attardo, Matt Berriman, Alan Christoffels, Mike Lehane, Dan Masiga, Yeya Toure

PLOS Neglected Tropical Diseases: published April 24, 2014 | https://doi.org/10.1371/journal.pntd.0002624

Policy Platform

Water, Sanitation, and Hygiene (WASH): A Critical Component for Sustainable Soil-Transmitted Helminth and Schistosomiasis Control

Suzy J. Campbell, Georgia B. Savage, Darren J. Gray, Jo-An M. Atkinson, Ricardo J. Soares Magalhães, Susana V. Nery, James S. McCarthy, Yael Velleman, James H. Wicken, Rebecca J. Traub, Gail M. Williams, Ross M. Andrews, Archie C. A. Clements

PLOS Neglected Tropical Diseases: published April 10, 2014 | https://doi.org/10.1371/journal.pntd.0002651

Historical Profiles and Perspectives

The Legacies of Eugène Jamot and La Jamotique

Francois-Xavier Mbopi-Keou, Laurent Bélec, Jean-Marie Milleliri, Chong-Gee Teo

PLOS Neglected Tropical Diseases: published April 24, 2014 | https://doi.org/10.1371/journal.pntd.0002635

Sleeping Sickness Epidemics and Colonial Responses in East and Central Africa, 1900–1940

Daniel R. Headrick

PLOS Neglected Tropical Diseases: published April 24, 2014 | https://doi.org/10.1371/journal.pntd.0002772

From Innovation to Application

Electronic Data Capture Tools for Global Health Programs: Evolution of LINKS, an Android-, Web-Based System

Alex Pavluck, Brian Chu, Rebecca Mann Flueckiger, Eric Ottesen

PLOS Neglected Tropical Diseases: published April 10, 2014 | https://doi.org/10.1371/journal.pntd.0002654

Review

PCR-Based Techniques for Leprosy Diagnosis: From the Laboratory to the Clinic

Alejandra Nóbrega Martinez, Carolina Talhari, Milton Ozório Moraes, Sinésio Talhari

PLOS Neglected Tropical Diseases: published April 10, 2014 | https://doi.org/10.1371/journal.pntd.0002655

Research Articles

Molecular Analysis of Echinostome Metacercariae from Their Second Intermediate Host Found in a Localised Geographic Region Reveals Genetic Heterogeneity and Possible Cryptic Speciation

Waraporn Noikong, Chalobol Wongsawad, Jong-Yil Chai, Supap Saenphet, Alan Trudgett

PLOS Neglected Tropical Diseases: published April 3, 2014 | https://doi.org/10.1371/journal.pntd.0002778

Expansion of Parasite-Specific CD4⁺ and CD8⁺ T Cells Expressing IL-10 Superfamily Cytokine Members and Their Regulation in Human Lymphatic Filariasis

Rajamanickam Anuradha, Parakkal Jovvian George, Luke E. Hanna, Paul Kumaran, Vedachalam Chandrasekaran, Thomas B. Nutman, Subash Babu

PLOS Neglected Tropical Diseases: published April 3, 2014 | https://doi.org/10.1371/journal.pntd.0002762

Challenges in Dengue Fever in the Elderly: Atypical Presentation and Risk of Severe Dengue and Hospita-Acquired Infection

Emily K. Rowe, Yee-Sin Leo, Joshua G. X. Wong, Tun-Linn Thein, Victor C. Gan, Linda K. Lee, David C. Lye

PLOS Neglected Tropical Diseases: published April 3, 2014 | https://doi.org/10.1371/journal.pntd.0002777

Correction: Challenges in Dengue Fever in the Elderly: Atypical Presentation and Risk of Severe Dengue and Hospita-Acquired Infection

Characterization of Guinea Pig Antibody Responses to Salivary Proteins of Triatoma infestans for the Development of a Triatomine Exposure Marker

Veronika Dorňáková, Renzo Salazar-Sanchez, Katty Borrini-Mayori, Oscar Carrion-Navarro, Michael Z. Levy, Günter A. Schaub, Alexandra Schwarz

PLOS Neglected Tropical Diseases: published April 3, 2014 | https://doi.org/10.1371/journal.pntd.0002783

Low Levels of Awareness Despite High Prevalence of Schistosomiasis among Communities in Nyalenda Informal Settlement, Kisumu City, Western Kenya

Gladys O. Odhiambo, Rosemary M. Musuva, Vincent O. Atuncha, Elizabeth T. Mutete, Maurice R. Odiere, Rosebella O. Onyango, Jane A. Alaii, Pauline N. M. Mwinzi

PLOS Neglected Tropical Diseases: published April 3, 2014 | https://doi.org/10.1371/journal.pntd.0002784

Prediction of High Incidence of Dengue in the Philippines

Anna L. Buczak, Benjamin Baugher, Steven M. Babin, Liane C. Ramac-Thomas, Erhan Guven, Yevgeniy Elbert, Phillip T. Koshute, John Mark S. Velasco, Vito G. Roque Jr, Enrique A. Tayag, In-Kyu Yoon, Sheri H. Lewis

PLOS Neglected Tropical Diseases: published April 10, 2014 | https://doi.org/10.1371/journal.pntd.0002771

Chagas Disease Vector Control in a Hyperendemic Setting: The First 11 Years of Intervention in Cochabamba, Bolivia

Natalisisy Espinoza, Rafael Borrás, Fernando Abad-Franch

PLOS Neglected Tropical Diseases: published April 3, 2014 | https://doi.org/10.1371/journal.pntd.0002782

The Effect of Multiple Rounds of Mass Drug Administration on the Association between Ocular Chlamydia trachomatis Infection and Follicular Trachoma in Preschool-Aged Children

Jennifer S. Lee, Beatriz E. Muñoz, Harran Mkocha, Charlotte A. Gaydos, Thomas C. Quinn, Sheila K. West

PLOS Neglected Tropical Diseases: published April 10, 2014 | https://doi.org/10.1371/journal.pntd.0002761

Trichuris suis and Oesophagostomum dentatum Show Different Sensitivity and Accumulation of Fenbendazole, Albendazole and Levamisole In Vitro

Tina V. A. Hansen, Peter Nejsum, Christian Friis, Annette Olsen, Stig Milan Thamsborg

PLOS Neglected Tropical Diseases: published April 3, 2014 | https://doi.org/10.1371/journal.pntd.0002752

Identification of Differentially Expressed Proteins from Leishmania amazonensis Associated with the Loss of Virulence of the Parasites

Rubens D. M. Magalhães, Mariana C. Duarte, Eliciane C. Mattos, Vivian T. Martins, Paula S. Lage, Miguel A. Chávez-Fumagalli, Daniela P. Lage, Daniel Menezes-Souza, Wiliam C. B. Régis, Maria J. Manso Alves, Manuel Soto, Carlos A. P. Tavares, Ronaldo A. P. Nagen, Eduardo A. F. Coelho

PLOS Neglected Tropical Diseases: published April 3, 2014 | https://doi.org/10.1371/journal.pntd.0002764

Correction: Identification of Differentially Expressed Proteins from Leishmania amazonensis Associated with the Loss of Virulence of the Parasites

Combined Inflammatory and Metabolic Defects Reflected by Reduced Serum Protein Levels in Patients with Buruli Ulcer Disease

Richard O. Phillips, Fred S. Sarfo, Jordi Landier, Reid Oldenburg, Michael Frimpong, Mark Wansbrough-Jones, Kabiru Abass, William Thompson, Mark Forson, Arnaud Fontanet, Fatoumata Niang, Caroline Demangel

PLOS Neglected Tropical Diseases: published April 10, 2014 | https://doi.org/10.1371/journal.pntd.0002786

Epidemiology of Coxiella burnetii Infection in Africa: A OneHealth Systematic Review

Sky Vanderburg, Matthew P. Rubach, Jo E. B. Halliday, Sarah Cleaveland, Elizabeth A. Reddy, John A. Crump

PLOS Neglected Tropical Diseases: published April 10, 2014 | https://doi.org/10.1371/journal.pntd.0002787

T-Cell Regulation in Lepromatous Leprosy

Kidist Bobosha, Louis Wilson, Krista E. van Meijgaarden, Yonas Bekele, Martha Zewdie, Jolien J. van der Ploeg- van Schip, Markos Abebe, Jemal Hussein, Saraswoti Khadge, Kapil D. Neupane, Deanna A. Hagge, Ekaterina S. Jordanova, Abraham Aseffa, Tom H. M. Ottenhoff, Annemieke Geluk

PLOS Neglected Tropical Diseases: published April 10, 2014 | https://doi.org/10.1371/journal.pntd.0002773

Transmission Dynamics of Borrelia turicatae from the Arthropod Vector

William K. Boyle, Hannah K. Wilder, Amanda M. Lawrence, Job E. Lopez

PLOS Neglected Tropical Diseases: published April 3, 2014 | https://doi.org/10.1371/journal.pntd.0002767

Mycobacterium ulcerans Fails to Infect through Skin Abrasions in a Guinea Pig Infection Model: Implications for Transmission

Heather R. Williamson, Lydia Mosi, Robert Donnell, Maha Aqqad, Richard W. Merritt, Pamela L. C. Small

PLOS Neglected Tropical Diseases: published April 10, 2014 | https://doi.org/10.1371/journal.pntd.0002770

Broad Spectrum Antiviral Activity of Favipiravir (T-705): Protection from Highly Lethal Inhalational Rift Valley Fever

Amy L. Caroline, Diana S. Powell, Laura M. Bethel, Tim D. Oury, Douglas S. Reed, Amy L. Hartman

PLOS Neglected Tropical Diseases: published April 10, 2014 | https://doi.org/10.1371/journal.pntd.0002790

Opportunity Cost for Early Treatment of Chagas Disease in Mexico

Janine M. Ramsey, Miguel Elizondo-Cano, Gilberto Sanchez-González, Adriana Peña-Nieves, Alejandro Figueroa-Lara

PLOS Neglected Tropical Diseases: published April 17, 2014 | https://doi.org/10.1371/journal.pntd.0002776

Comparison between Itraconazole and Cotrimoxazole in the Treatment of Paracoccidiodomycosis

Ricardo de Souza Cavalcante, Tatiane Fernanda Sylvestre, Adriele Dandara Levorato, Lídia Rachel de Carvalho, Rinaldo Poncio Mendes

PLOS Neglected Tropical Diseases: published April 17, 2014 | https://doi.org/10.1371/journal.pntd.0002793

Leishmania-HIV Co-infection: Clinical Presentation and Outcomes in an Urban Area in Brazil

Gláucia F. Cota, Marcos R. de Sousa, Andrea Laender Pessoa de Mendonça, Allan Patrocinio, Luiza Siqueira Assunção, Sidnei Rodrigues de Faria, Ana Rabello

PLOS Neglected Tropical Diseases: published April 17, 2014 | https://doi.org/10.1371/journal.pntd.0002816

Correction: Leishmania-HIV Co-infection: Clinical Presentation and Outcomes in an Urban Area in Brazil

Gentamicin-Attenuated Leishmania infantum Vaccine: Protection of Dogs against Canine Visceral Leishmaniosis in Endemic Area of Southeast of Iran

Hamid Daneshvar, Mohammad Javad Namazi, Hossein Kamiabi, Richard Burchmore, Sarah Cleaveland, Stephen Phillips

PLOS Neglected Tropical Diseases: published April 17, 2014 | https://doi.org/10.1371/journal.pntd.0002757

Correction: Gentamicin-Attenuated Leishmania infantum Vaccine: Protection of Dogs against Canine Visceral Leishmaniosis in Endemic Area of Southeast of Iran

Differing Patterns of Selection and Geospatial Genetic Diversity within Two Leading Plasmodium vivax Candidate Vaccine Antigens

Christian M. Parobek, Jeffrey A. Bailey, Nicholas J. Hathaway, Duong Socheat, William O. Rogers, Jonathan J. Juliano

PLOS Neglected Tropical Diseases: published April 17, 2014 | https://doi.org/10.1371/journal.pntd.0002796

Air Travel Is Associated with Intracontinental Spread of Dengue Virus Serotypes 1–3 in Brazil

Marcio R. T. Nunes, Gustavo Palacios, Nuno Rodrigues Faria, Edivaldo Costa Sousa Jr, Jamilla A. Pantoja, Sueli G. Rodrigues, Valéria L. Carvalho, Daniele B. A. Medeiros, Nazir Savji, Guy Baele, Marc A. Suchard, Philippe Lemey, Pedro F. C. Vasconcelos, W. Ian Lipkin

PLOS Neglected Tropical Diseases: published April 17, 2014 | https://doi.org/10.1371/journal.pntd.0002769

El Niño Southern Oscillation and Leptospirosis Outbreaks in New Caledonia

Daniel Weinberger, Noémie Baroux, Jean-Paul Grangeon, Albert I. Ko, Cyrille Goarant

PLOS Neglected Tropical Diseases: published April 17, 2014 | https://doi.org/10.1371/journal.pntd.0002798

Recombinant Paracoccin Reproduces the Biological Properties of the Native Protein and Induces Protective Th1 Immunity against Paracoccidioides brasiliensis Infection

Ana Claudia Paiva Alegre, Aline Ferreira Oliveira, Fausto Bruno Dos Reis Almeida, Maria Cristina Roque-Barreira, Ebert Seixas Hanna

PLOS Neglected Tropical Diseases: published April 17, 2014 | https://doi.org/10.1371/journal.pntd.0002788

Structures of Trypanosoma brucei Methionyl-tRNA Synthetase with Urea-Based Inhibitors Provide Guidance for Drug Design against Sleeping Sickness

Cho Yeow Koh, Jessica E. Kim, Allan B. Wetzel, Will J. de van der Schueren, Sayaka Shibata, Ranae M. Ranade, Jiyun Liu, Zhongsheng Zhang, J. Robert Gillespie, Frederick S. Buckner, Christophe L. M. J. Verlinde, Erkang Fan, Wim G. J. Hol

PLOS Neglected Tropical Diseases: published April 17, 2014 | https://doi.org/10.1371/journal.pntd.0002775

Knowledge, Attitudes and Practices Related to Visceral Leishmaniasis in Rural Communities of Amhara State: A Longitudinal Study in Northwest Ethiopia

Noemí López-Perea, Luis Sordo, Endalamaw Gadisa, Israel Cruz, Tsegaye Hailu, Javier Moreno, Abraham Aseffa, Carmen Cañavate, Estefanía Custodio

PLOS Neglected Tropical Diseases: published April 17, 2014 | https://doi.org/10.1371/journal.pntd.0002799

Experimental Infection of Rhesus Macaques and Common Marmosets with a European Strain of West Nile Virus

Babs E. Verstrepen, Zahra Fagrouch, Melanie van Heteren, Hester Buitendijk, Tom Haaksma, Niels Beenhakker, Giorgio Palù, Justin M. Richner, Michael S. Diamond, Willy M. Bogers, Luisa Barzon, Stefan Chabierski, Sebastian Ulbert, Ivanela Kondova, Ernst J. Verschoor

PLOS Neglected Tropical Diseases: published April 17, 2014 | https://doi.org/10.1371/journal.pntd.0002797

Distribution and Clinical Manifestations of Cryptosporidium Species and Subtypes in HIV/AIDS Patients in Ethiopia

Haileeyesus Adamu, Beyene Petros, Guoqing Zhang, Hailu Kassa, Said Amer, Jianbin Ye, Yaoyu Feng, Lihua Xiao

PLOS Neglected Tropical Diseases: published April 17, 2014 | https://doi.org/10.1371/journal.pntd.0002831

Methods to Determine the Transcriptomes of Trypanosomes in Mixtures with Mammalian Cells: The Effects of Parasite Purification and Selective cDNA Amplification

Julius Mulindwa, Abeer Fadda, Clementine Merce, Enoch Matovu, John Enyaru, Christine Clayton

PLOS Neglected Tropical Diseases: published April 17, 2014 | https://doi.org/10.1371/journal.pntd.0002806

Antigen-Specific Memory B-cell Responses to Enterotoxigenic Escherichia coli Infection in Bangladeshi Adults

Mohammad Murshid Alam, Amena Aktar, Sadia Afrin, Mohammad Arif Rahman, Sarmin Aktar, Taher Uddin, M. Arifur Rahman, Deena Al Mahbuba, Fahima Chowdhury, Ashraful Islam Khan, Taufiqur Rahman Bhuiyan, Yasmin Ara Begum, Edward T. Ryan, Stephen B. Calderwood, Ann-Mari Svennerholm, Firdausi Qadri

PLOS Neglected Tropical Diseases: published April 24, 2014 | https://doi.org/10.1371/journal.pntd.0002822

The Homeodomain Protein Ladybird Late Regulates Synthesis of Milk Proteins during Pregnancy in the Tsetse Fly (Glossina morsitans)

Geoffrey M. Attardo, Joshua B. Benoit, Veronika Michalkova, Kevin R. Patrick, Tyler B. Krause, Serap Aksoy

PLOS Neglected Tropical Diseases: published April 24, 2014 | https://doi.org/10.1371/journal.pntd.0002645

Modeling to Predict Cases of Hantavirus Pulmonary Syndrome in Chile

Elaine O. Nsoesie, Sumiko R. Mekaru, Naren Ramakrishnan, Madhav V. Marathe, John S. Brownstein

PLOS Neglected Tropical Diseases: published April 24, 2014 | https://doi.org/10.1371/journal.pntd.0002779

Circulating CD14^brightCD16⁺ ‘Intermediate’ Monocytes Exhibit Enhanced Parasite Pattern Recognition in Human Helminth Infection

Joseph D. Turner, Claire D. Bourke, Lynn Meurs, Moustapha Mbow, Tandakha Ndiaye Dièye, Souleymane Mboup, Katja Polman, Adrian P. Mountford

PLOS Neglected Tropical Diseases: published April 24, 2014 | https://doi.org/10.1371/journal.pntd.0002817

Diagnostic Performance of Schistosoma Real-Time PCR in Urine Samples from Kenyan Children Infected with Schistosoma haematobium: Day-to-day Variation and Follow-up after Praziquantel Treatment

Natalie V. S. Vinkeles Melchers, Govert J. van Dam, David Shaproski, Anthony I. Kahama, Eric A. T. Brienen, Birgitte J. Vennervald, Lisette van Lieshout

PLOS Neglected Tropical Diseases: published April 17, 2014 | https://doi.org/10.1371/journal.pntd.0002807

Model-Based Investigations of Different Vector-Related Intervention Strategies to Eliminate Visceral Leishmaniasis on the Indian Subcontinent

Anette Stauch, Hans-Peter Duerr, Albert Picado, Bart Ostyn, Shyam Sundar, Suman Rijal, Marleen Boelaert, Jean-Claude Dujardin, Martin Eichner

PLOS Neglected Tropical Diseases: published April 24, 2014 | https://doi.org/10.1371/journal.pntd.0002810

Aquaporins Are Critical for Provision of Water during Lactation and Intrauterine Progeny Hydration to Maintain Tsetse Fly Reproductive Success

Joshua B. Benoit, Immo A. Hansen, Geoffrey M. Attardo, Veronika Michalková, Paul O. Mireji, Joel L. Bargul, Lisa L. Drake, Daniel K. Masiga, Serap Aksoy

PLOS Neglected Tropical Diseases: published April 24, 2014 | https://doi.org/10.1371/journal.pntd.0002517

Insights into the Trypanosome-Host Interactions Revealed through Transcriptomic Analysis of Parasitized Tsetse Fly Salivary Glands

Erich Loza Telleria, Joshua B. Benoit, Xin Zhao, Amy F. Savage, Sandesh Regmi, Thiago Luiz Alves e Silva, Michelle O'Neill, Serap Aksoy

PLOS Neglected Tropical Diseases: published April 24, 2014 | https://doi.org/10.1371/journal.pntd.0002649

Presence of Extensive Wolbachia Symbiont Insertions Discovered in the Genome of Its Host Glossina morsitans morsitans

Corey Brelsfoard, George Tsiamis, Marco Falchetto, Ludvik M. Gomulski, Erich Telleria, Uzma Alam, Vangelis Doudoumis, Francesca Scolari, Joshua B. Benoit, Martin Swain, Peter Takac, Anna R. Malacrida, Kostas Bourtzis, Serap Aksoy

PLOS Neglected Tropical Diseases: published April 24, 2014 | https://doi.org/10.1371/journal.pntd.0002728

Immunohistochemical Monitoring of Wound Healing in Antibiotic Treated Buruli Ulcer Patients

Arianna Andreoli, Marie-Thérèse Ruf, Ghislain Emmanuel Sopoh, Peter Schmid, Gerd Pluschke

PLOS Neglected Tropical Diseases: published April 24, 2014 | https://doi.org/10.1371/journal.pntd.0002809

Reproductive Status of Onchocerca volvulus after Ivermectin Treatment in an Ivermectin-Naïve and a Frequently Treated Population from Cameroon

Hugues C. Nana-Djeunga, Catherine Bourguinat, Sébastien D. Pion, Jean Bopda, Jonas A. Kengne-Ouafo, Flobert Njiokou, Roger K. Prichard, Samuel Wanji, Joseph Kamgno, Michel Boussinesq

PLOS Neglected Tropical Diseases: published April 24, 2014 | https://doi.org/10.1371/journal.pntd.0002824

An Investigation into the Protein Composition of the Teneral Glossina morsitans morsitans Peritrophic Matrix

Clair Rose, Rodrigo Belmonte, Stuart D. Armstrong, Gemma Molyneux, Lee R. Haines, Michael J. Lehane, Jonathan Wastling, Alvaro Acosta-Serrano

PLOS Neglected Tropical Diseases: published April 24, 2014 | https://doi.org/10.1371/journal.pntd.0002691

Characterization of the Early Inflammatory Infiltrate at the Feeding Site of Infected Sand Flies in Mice Protected from Vector-Transmitted Leishmania major by Exposure to Uninfected Bites

Clarissa Teixeira, Regis Gomes, Fabiano Oliveira, Claudio Meneses, Dana C. Gilmore, Dia-Eldin A. Elnaiem, Jesus G. Valenzuela, Shaden Kamhawi

PLOS Neglected Tropical Diseases: published April 24, 2014 | https://doi.org/10.1371/journal.pntd.0002781

Odorant and Gustatory Receptors in the Tsetse Fly Glossina morsitans morsitans

George F. O. Obiero, Paul O. Mireji, Steven R. G. Nyanjom, Alan Christoffels, Hugh M. Robertson, Daniel K. Masiga

PLOS Neglected Tropical Diseases: published April 24, 2014 | https://doi.org/10.1371/journal.pntd.0002663

Leishmania aethiopica Field Isolates Bearing an Endosymbiontic dsRNA Virus Induce Pro-inflammatory Cytokine Response

Haroun Zangger, Asrat Hailu, Chantal Desponds, Lon-Fye Lye, Natalia S. Akopyants, Deborah E. Dobson, Catherine Ronet, Hashim Ghalib, Stephen M. Beverley, Nicolas Fasel

PLOS Neglected Tropical Diseases: published April 24, 2014 | https://doi.org/10.1371/journal.pntd.0002836

Use of a Synthetic Biosensor for Neutralizing Activity-Biased Selection of Monoclonal Antibodies against Atroxlysin-I, an Hemorrhagic Metalloproteinase from Bothrops atrox Snake Venom

Francisco Santos Schneider, Dung Le Nguyen, Karen Larissa Castro, Sandra Cobo, Ricardo Andrez Machado de Avila, Nivia de Assis Ferreira, Eladio Flores Sanchez, Christophe Nguyen, Claude Granier, Pascale Galéa, Carlos Chávez-Olortegui, Franck Molina

PLOS Neglected Tropical Diseases: published April 24, 2014 | https://doi.org/10.1371/journal.pntd.0002826

Dicer-2-Dependent Activation of Culex Vago Occurs via the TRAF-Rel2 Signaling Pathway

Prasad N. Paradkar, Jean-Bernard Duchemin, Rhonda Voysey, Peter J. Walker

PLOS Neglected Tropical Diseases: published April 24, 2014 | https://doi.org/10.1371/journal.pntd.0002823

Sulphonylurea Usage in Melioidosis Is Associated with Severe Disease and Suppressed Immune Response

Xiang Liu, Geraldine Foo, Wan Peng Lim, Sharada Ravikumar, Siew Hoon Sim, Mar Soe Win, Jessamine Geraldine Goh, Joan Hui Juan Lim, Ying Hui Ng, Dale Fisher, Chin Meng Khoo, Gladys Tan, Louis Yi Ann Chai

PLOS Neglected Tropical Diseases: published April 24, 2014 | https://doi.org/10.1371/journal.pntd.0002795

A Thrombomodulin Mutation that Impairs Active Protein C Generation Is Detrimental in Severe Pneumonia-Derived Gram-Negative Sepsis (Melioidosis)

Liesbeth M. Kager, W. Joost Wiersinga, Joris J. T. H. Roelofs, Onno J. de Boer, Hartmut Weiler, Cornelis van 't Veer, Tom van der Poll

PLOS Neglected Tropical Diseases: published April 24, 2014 | https://doi.org/10.1371/journal.pntd.0002819