Cover
Mycobacterium ulcerans infection in an adult common ringtail possum (Pseudocheirus peregrinus).
Buruli ulcer is a skin disease caused by Mycobacterium ulcerans, with endemicity predominantly in sub-Saharan Africa and southeastern Australia. Transmission and the environmental reservoir(s) of the bacterium remain elusive. Investigations have detected Mycobacterium ulcerans DNA in a variety of Australian environmental samples, including faeces of native possums (pictured) with and without clinical evidence of infection. O'Brien et al.
Image Credit: Janet Fyfe and Christina McCowan
Editorial
Aboriginal Populations and Their Neglected Tropical Diseases
Peter J. Hotez
PLOS Neglected Tropical Diseases: published January 30, 2014 | https://doi.org/10.1371/journal.pntd.0002286
Viewpoints
TDR: (Back) Making a Difference
John C. Reeder
PLOS Neglected Tropical Diseases: published January 9, 2014 | https://doi.org/10.1371/journal.pntd.0002531
Symposium
A 21-Year-Old Student with Fever and Profound Jaundice
Samson Ejiji Isa, Kenneth Ikenna Onyedibe, Mark Ojogba Okolo, Abiayi Elmina Abiba, Johnson Simon Mafuka, Gomerep Samuel Simji, Shehu Yakubu Nathan, Ubong Aniefok Udoh, Sati Klein Awang, Daniel Zanyu Egah, Edmond Banle Banwat, Melanie Newport, Ahmed Ahmed
PLOS Neglected Tropical Diseases: published January 9, 2014 | https://doi.org/10.1371/journal.pntd.0002534
Reviews
Estimating the Burden of Japanese Encephalitis Virus and Other Encephalitides in Countries of the Mekong Region
Arnaud Tarantola, Flavie Goutard, Paul Newton, Xavier de Lamballerie, Olivier Lortholary, Julien Cappelle, Philippe Buchy
PLOS Neglected Tropical Diseases: published January 30, 2014 | https://doi.org/10.1371/journal.pntd.0002533
Hard Tick Factors Implicated in Pathogen Transmission
Xiang Ye Liu, Sarah I. Bonnet
PLOS Neglected Tropical Diseases: published January 30, 2014 | https://doi.org/10.1371/journal.pntd.0002566
Research Articles
A Scoping Review and Prevalence Analysis of Soil-Transmitted Helminth Infections in Honduras
Ana Lourdes Sanchez, José Antonio Gabrie, María Mercedes Rueda, Rosa Elena Mejia, Maria Elena Bottazzi, Maritza Canales
PLOS Neglected Tropical Diseases: published January 23, 2014 | https://doi.org/10.1371/journal.pntd.0002653
The Changing Epidemiology of Murray Valley Encephalitis in Australia: The 2011 Outbreak and a Review of the Literature
Linda A. Selvey, Lynne Dailey, Michael Lindsay, Paul Armstrong, Sean Tobin, Ann P. Koehler, Peter G. Markey, David W. Smith
PLOS Neglected Tropical Diseases: published January 23, 2014 | https://doi.org/10.1371/journal.pntd.0002656
Strong Association between Serological Status and Probability of Progression to Clinical Visceral Leishmaniasis in Prospective Cohort Studies in India and Nepal
Epco Hasker, Paritosh Malaviya, Kamlesh Gidwani, Albert Picado, Bart Ostyn, Sangeeta Kansal, Rudra Pratap Singh, Om Prakash Singh, Ankita Chourasia, Abhishek Kumar Singh, Ravi Shankar, Mary E. Wilson, Basudha Khanal, Suman Rijal, Marleen Boelaert, Shyam Sundar
PLOS Neglected Tropical Diseases: published January 23, 2014 | https://doi.org/10.1371/journal.pntd.0002657
L925I Mutation in the Para-Type Sodium Channel Is Associated with Pyrethroid Resistance in Triatoma infestans from the Gran Chaco Region
Natalia Capriotti, Gastón Mougabure-Cueto, Rolando Rivera-Pomar, Sheila Ons
PLOS Neglected Tropical Diseases: published January 23, 2014 | https://doi.org/10.1371/journal.pntd.0002659
Safety and Efficacy of Single Dose versus Multiple Doses of AmBisome® for Treatment of Visceral Leishmaniasis in Eastern Africa: A Randomised Trial
Eltahir A. G. Khalil, Teklu Weldegebreal, Brima M. Younis, Raymond Omollo, Ahmed M. Musa, Workagegnehu Hailu, Abuzaid A. Abuzaid, Thomas P. C. Dorlo, Zewdu Hurissa, Sisay Yifru, William Haleke, Peter G. Smith, Sally Ellis, Manica Balasegaram, Ahmed M. EL-Hassan, Gerard J. Schoone, Monique Wasunna, Robert Kimutai, Tansy Edwards, Asrat Hailu
PLOS Neglected Tropical Diseases: published January 16, 2014 | https://doi.org/10.1371/journal.pntd.0002613
Regional Differences of Leptospirosis in Sri Lanka: Observations from a Flood-Associated Outbreak in 2011
Suneth B. Agampodi, Niroshan J. Dahanayaka, Anoma K. Bandaranayaka, Manoj Perera, Sumudu Priyankara, Prasanna Weerawansa, Michael A. Matthias, Joseph M. Vinetz
PLOS Neglected Tropical Diseases: published January 16, 2014 | https://doi.org/10.1371/journal.pntd.0002626
Increase in TGF-β Secreting CD4+CD25+ FOXP3+ T Regulatory Cells in Anergic Lepromatous Leprosy Patients
Chaman Saini, Venkatesh Ramesh, Indira Nath
PLOS Neglected Tropical Diseases: published January 16, 2014 | https://doi.org/10.1371/journal.pntd.0002639
Clinical Associations of Human T-Lymphotropic Virus Type 1 Infection in an Indigenous Australian Population
Lloyd Einsiedel, Tim Spelman, Emma Goeman, Olivier Cassar, Mick Arundell, Antoine Gessain
PLOS Neglected Tropical Diseases: published January 16, 2014 | https://doi.org/10.1371/journal.pntd.0002643
Aptamer Based, Non-PCR, Non-Serological Detection of Chagas Disease Biomarkers in Trypanosoma cruzi Infected Mice
Rana Nagarkatti, Fernanda Fortes de Araujo, Charu Gupta, Alain Debrabant
PLOS Neglected Tropical Diseases: published January 16, 2014 | https://doi.org/10.1371/journal.pntd.0002650
Heterogeneities in Leishmania infantum Infection: Using Skin Parasite Burdens to Identify Highly Infectious Dogs
Orin Courtenay, Connor Carson, Leo Calvo-Bado, Lourdes M. Garcez, Rupert J. Quinnell
PLOS Neglected Tropical Diseases: published January 9, 2014 | https://doi.org/10.1371/journal.pntd.0002583
An Insight into the Transcriptome of the Digestive Tract of the Bloodsucking Bug, Rhodnius prolixus
José M. C. Ribeiro, Fernando A. Genta, Marcos H. F. Sorgine, Raquel Logullo, Rafael D. Mesquita, Gabriela O. Paiva-Silva, David Majerowicz, Marcelo Medeiros, Leonardo Koerich, Walter R. Terra, Clélia Ferreira, André C. Pimentel, Paulo M. Bisch, Daniel C. Leite, Michelle M. P. Diniz, João Lídio da S. G. V. Junior, Manuela L. Da Silva, Ricardo N. Araujo, Ana Caroline P. Gandara, Sébastien Brosson, Didier Salmon, Sabrina Bousbata, Natalia González-Caballero, Ariel Mariano Silber, Michele Alves-Bezerra, Katia C. Gondim, Mário Alberto C. Silva-Neto, Georgia C. Atella, Helena Araujo, Felipe A. Dias, Carla Polycarpo, Raquel J. Vionette-Amaral, Patrícia Fampa, Ana Claudia A. Melo, Aparecida S. Tanaka, Carsten Balczun, José Henrique M. Oliveira, Renata L. S. Gonçalves, Cristiano Lazoski, Rolando Rivera-Pomar, Luis Diambra, Günter A. Schaub, Elói S. Garcia, Patrícia Azambuja, Glória R. C. Braz, Pedro L. Oliveira
PLOS Neglected Tropical Diseases: published January 9, 2014 | https://doi.org/10.1371/journal.pntd.0002594
Standardising Visual Control Devices for Tsetse Flies: Central and West African Species Glossina palpalis palpalis
Dramane Kaba, Tusevo Zacarie, Alexis Makumyaviri M'Pondi, Flobert Njiokou, Henriette Bosson-Vanga, Thomas Kröber, Andrew McMullin, Steve Mihok, Patrick M. Guerin
PLOS Neglected Tropical Diseases: published January 9, 2014 | https://doi.org/10.1371/journal.pntd.0002601
Bioassay-Guided Fractionation of Extracts from Codiaeum variegatum against Entamoeba histolytica Discovers Compounds That Modify Expression of Ceramide Biosynthesis Related Genes
Emmanuel Mfotie Njoya, Christian Weber, Nora Adriana Hernandez-Cuevas, Chung-Chau Hon, Yves Janin, Melanie F. G. Kamini, Paul F. Moundipa, Nancy Guillén
PLOS Neglected Tropical Diseases: published January 9, 2014 | https://doi.org/10.1371/journal.pntd.0002607
Orally Active Antischistosomal Early Leads Identified from the Open Access Malaria Box
Katrin Ingram-Sieber, Noemi Cowan, Gordana Panic, Mireille Vargas, Nuha R. Mansour, Quentin D. Bickle, Timothy N. C. Wells, Thomas Spangenberg, Jennifer Keiser
PLOS Neglected Tropical Diseases: published January 9, 2014 | https://doi.org/10.1371/journal.pntd.0002610
Animal Reservoir, Natural and Socioeconomic Variations and the Transmission of Hemorrhagic Fever with Renal Syndrome in Chenzhou, China, 2006–2010
Hong Xiao, Huai-Yu Tian, Li-Dong Gao, Hai-Ning Liu, Liang-Song Duan, Nicole Basta, Bernard Cazelles, Xiu-Jun Li, Xiao-Ling Lin, Hong-Wei Wu, Bi-Yun Chen, Hui-Suo Yang, Bing Xu, Bryan Grenfell
PLOS Neglected Tropical Diseases: published January 9, 2014 | https://doi.org/10.1371/journal.pntd.0002615
Next Generation Sequencing Reveals Regulation of Distinct Aedes microRNAs during Chikungunya Virus Development
Jatin Shrinet, Shanu Jain, Jaspreet Jain, Raj K. Bhatnagar, Sujatha Sunil
PLOS Neglected Tropical Diseases: published January 9, 2014 | https://doi.org/10.1371/journal.pntd.0002616
Repeated Exposure to Lutzomyia intermedia Sand Fly Saliva Induces Local Expression of Interferon-Inducible Genes Both at the Site of Injection in Mice and in Human Blood
Tiffany Weinkopff, Camila I. de Oliveira, Augusto M. de Carvalho, Yazmin Hauyon-La Torre, Aline C. Muniz, Jose Carlos Miranda, Aldina Barral, Fabienne Tacchini-Cottier
PLOS Neglected Tropical Diseases: published January 9, 2014 | https://doi.org/10.1371/journal.pntd.0002627
Cofactor-Independent Phosphoglycerate Mutase from Nematodes Has Limited Druggability, as Revealed by Two High-Throughput Screens
Gregory J. Crowther, Michael L. Booker, Min He, Ting Li, Sylvine Raverdy, Jacopo F. Novelli, Panqing He, Natalie R. G. Dale, Amy M. Fife, Robert H. Barker Jr, Martin L. Kramer, Wesley C. Van Voorhis, Clotilde K. S. Carlow, Ming-Wei Wang
PLOS Neglected Tropical Diseases: published January 9, 2014 | https://doi.org/10.1371/journal.pntd.0002628
Functional Characterization of Peroxiredoxins from the Human Protozoan Parasite Giardia intestinalis
Daniela Mastronicola, Micol Falabella, Fabrizio Testa, Leopoldo Paolo Pucillo, Miguel Teixeira, Paolo Sarti, Lígia M. Saraiva, Alessandro Giuffrè
PLOS Neglected Tropical Diseases: published January 9, 2014 | https://doi.org/10.1371/journal.pntd.0002631
Molecular Evolution of Zika Virus during Its Emergence in the 20th Century
Oumar Faye, Caio C. M. Freire, Atila Iamarino, Ousmane Faye, Juliana Velasco C. de Oliveira, Mawlouth Diallo, Paolo M. A. Zanotto, Amadou Alpha Sall
PLOS Neglected Tropical Diseases: published January 9, 2014 | https://doi.org/10.1371/journal.pntd.0002636
Production of CXC and CC Chemokines by Human Antigen-Presenting Cells in Response to Lassa Virus or Closely Related Immunogenic Viruses, and in Cynomolgus Monkeys with Lassa Fever
Delphine Pannetier, Stéphanie Reynard, Marion Russier, Xavier Carnec, Sylvain Baize
PLOS Neglected Tropical Diseases: published January 9, 2014 | https://doi.org/10.1371/journal.pntd.0002637
Diagnostic Accuracy of Five Serologic Tests for Strongyloides stercoralis Infection
Zeno Bisoffi, Dora Buonfrate, Marco Sequi, Rojelio Mejia, Ruben O. Cimino, Alejandro J. Krolewiecki, Marco Albonico, Maria Gobbo, Stefania Bonafini, Andrea Angheben, Ana Requena-Mendez, José Muñoz, Thomas B. Nutman
PLOS Neglected Tropical Diseases: published January 9, 2014 | https://doi.org/10.1371/journal.pntd.0002640
Nodule Worm Infection in Humans and Wild Primates in Uganda: Cryptic Species in a Newly Identified Region of Human Transmission
Ria R. Ghai, Colin A. Chapman, Patrick A. Omeja, T. Jonathan Davies, Tony L. Goldberg
PLOS Neglected Tropical Diseases: published January 9, 2014 | https://doi.org/10.1371/journal.pntd.0002641
Predicting the Impact of Vaccination on the Transmission Dynamics of Typhoid in South Asia: A Mathematical Modeling Study
Virginia E. Pitzer, Cayley C. Bowles, Stephen Baker, Gagandeep Kang, Veeraraghavan Balaji, Jeremy J. Farrar, Bryan T. Grenfell
PLOS Neglected Tropical Diseases: published January 9, 2014 | https://doi.org/10.1371/journal.pntd.0002642
Characterization of a Gene Family Encoding SEA (Sea-urchin Sperm Protein, Enterokinase and Agrin)-Domain Proteins with Lectin-Like and Heme-Binding Properties from Schistosoma japonicum
Evaristus Chibunna Mbanefo, Mihoko Kikuchi, Nguyen Tien Huy, Mohammed Nasir Shuaibu, Mahamoud Sama Cherif, Chuanxin Yu, Masahiro Wakao, Yasuo Suda, Kenji Hirayama
PLOS Neglected Tropical Diseases: published January 9, 2014 | https://doi.org/10.1371/journal.pntd.0002644
LmaPA2G4, a Homolog of Human Ebp1, Is an Essential Gene and Inhibits Cell Proliferation in L. major
Brianna Norris-Mullins, Kaitlin VanderKolk, Paola Vacchina, Michelle V. Joyce, Miguel A. Morales
PLOS Neglected Tropical Diseases: published January 9, 2014 | https://doi.org/10.1371/journal.pntd.0002646
Molecular Epidemiology of Crimean-Congo Hemorrhagic Fever Virus in Kosovo
Luka Fajs, Xhevat Jakupi, Salih Ahmeti, Isme Humolli, Isuf Dedushaj, Tatjana Avšič-Županc
PLOS Neglected Tropical Diseases: published January 9, 2014 | https://doi.org/10.1371/journal.pntd.0002647
Risk Factors for Visceral Leishmaniasis Relapse in Immunocompetent Patients following Treatment with 20 mg/kg Liposomal Amphotericin B (Ambisome) in Bihar, India
Sakib Burza, Prabhat K. Sinha, Raman Mahajan, María Angeles Lima, Gaurab Mitra, Neena Verma, Manica Balsegaram, Pradeep Das
PLOS Neglected Tropical Diseases: published January 2, 2014 | https://doi.org/10.1371/journal.pntd.0002536
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Recombinant Antigens from Phlebotomus perniciosus Saliva as Markers of Canine Exposure to Visceral Leishmaniases Vector
Jan Drahota, Ines Martin-Martin, Petra Sumova, Iva Rohousova, Maribel Jimenez, Ricardo Molina, Petr Volf
PLOS Neglected Tropical Diseases: published January 2, 2014 | https://doi.org/10.1371/journal.pntd.0002597
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Sakib Burza, Prabhat K. Sinha, Raman Mahajan, María Angeles Lima, Gaurab Mitra, Neena Verma, Manica Balasegarem, Pradeep Das
PLOS Neglected Tropical Diseases: published January 2, 2014 | https://doi.org/10.1371/journal.pntd.0002603
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Analysis of the Vaccine Potential of Plasmid DNA Encoding Nine Mycolactone Polyketide Synthase Domains in Mycobacterium ulcerans Infected Mice
Virginie Roupie, Sacha J. Pidot, Tobba Einarsdottir, Christophe Van Den Poel, Fabienne Jurion, Timothy P. Stinear, Kris Huygen
PLOS Neglected Tropical Diseases: published January 2, 2014 | https://doi.org/10.1371/journal.pntd.0002604
Household-Level Expenditure on Protective Measures Against Mosquitoes on the Island of La Réunion, France
Josselin Thuilliez, Claire Bellia, Jean-Sébastien Dehecq, Olivier Reilhes
PLOS Neglected Tropical Diseases: published January 2, 2014 | https://doi.org/10.1371/journal.pntd.0002609
Post Kala-Azar Dermal Leishmaniasis following Treatment with 20 mg/kg Liposomal Amphotericin B (Ambisome) for Primary Visceral Leishmaniasis in Bihar, India
Sakib Burza, Prabhat Kumar Sinha, Raman Mahajan, Marta González Sanz, María Angeles Lima, Gaurab Mitra, Neena Verma, Pradeep Das
PLOS Neglected Tropical Diseases: published January 2, 2014 | https://doi.org/10.1371/journal.pntd.0002611
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Clinical Features and Risk Factors of Oedematous Mycobacterium ulcerans Lesions in an Australian Population: Beware Cellulitis in an Endemic Area
Daniel P. O'Brien, N. Deborah Friedman, Anthony McDonald, Peter Callan, Andrew Hughes, Eugene Athan
PLOS Neglected Tropical Diseases: published January 2, 2014 | https://doi.org/10.1371/journal.pntd.0002612
Phytol, a Diterpene Alcohol from Chlorophyll, as a Drug against Neglected Tropical Disease Schistosomiasis Mansoni
Josué de Moraes, Rosimeire N. de Oliveira, Jéssica P. Costa, Antonio L. G. Junior, Damião P. de Sousa, Rivelilson M. Freitas, Silmara M. Allegretti, Pedro L. S. Pinto
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Accelerated Detection of Mycolactone Production and Response to Antibiotic Treatment in a Mouse Model of Mycobacterium ulcerans Disease
Paul J. Converse, Yalan Xing, Ki Hyun Kim, Sandeep Tyagi, Si-Yang Li, Deepak V. Almeida, Eric L. Nuermberger, Jacques H. Grosset, Yoshito Kishi
PLOS Neglected Tropical Diseases: published January 2, 2014 | https://doi.org/10.1371/journal.pntd.0002618
Reinfection of Dogs with Fish-Borne Zoonotic Trematodes in Northern Vietnam following a Single Treatment with Praziquantel
Sofie Nissen, Lan Anh Thi Nguyen, Stig Milan Thamsborg, Anders Dalsgaard, Maria Vang Johansen
PLOS Neglected Tropical Diseases: published January 2, 2014 | https://doi.org/10.1371/journal.pntd.0002625
EmTIP, a T-Cell Immunomodulatory Protein Secreted by the Tapeworm Echinococcus multilocularis Is Important for Early Metacestode Development
Justin Komguep Nono, Manfred B. Lutz, Klaus Brehm
PLOS Neglected Tropical Diseases: published January 2, 2014 | https://doi.org/10.1371/journal.pntd.0002632
The Trypanosoma cruzi Satellite DNA OligoC-TesT and Trypanosoma cruzi Kinetoplast DNA OligoC-TesT for Diagnosis of Chagas Disease: A Multi-cohort Comparative Evaluation Study
Koen De Winne, Philippe Büscher, Alejandro O. Luquetti, Suelene B. N. Tavares, Rodrigo A. Oliveira, Aldo Solari, Ines Zulantay, Werner Apt, Patricio Diosque, Mercedes Monje Rumi, Nuria Gironès, Manuel Fresno, Rogelio Lopez-Velez, José A. Perez-Molina, Begoña Monge-Maillo, Lineth Garcia, Stijn Deborggraeve
PLOS Neglected Tropical Diseases: published January 2, 2014 | https://doi.org/10.1371/journal.pntd.0002633
The Burden of Parasitic Zoonoses in Nepal: A Systematic Review
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Scrub Typhus Is an Under-recognized Cause of Acute Febrile Illness with Acute Kidney Injury in India
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PLOS Neglected Tropical Diseases: published January 30, 2014 | https://doi.org/10.1371/journal.pntd.0002605
Risk Factors for Disseminated Histoplasmosis in a Cohort of HIV-Infected Patients in French Guiana
Mathieu Nacher, Antoine Adenis, Denis Blanchet, Vincent Vantilcke, Magalie Demar, Célia Basurko, Emilie Gaubert-Maréchal, Julie Dufour, Christine Aznar, Bernard Carme, Pierre Couppié
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