November 2013

Cover

Community health workers deliver oral cholera vaccine.

Community health workers visit rural Haitian villages with oral cholera vaccine and health and hygiene education messages. See Aibana et al.

Image Credit: Jonathan Lascher

Editorial

Disseminated Histoplasmosis in HIV-Infected Patients in South America: A Neglected Killer Continues on Its Rampage

Mathieu Nacher, Antoine Adenis, Sigrid Mc Donald, Margarete Do Socorro Mendonca Gomes, Shanti Singh, Ivina Lopes Lima, Rosilene Malcher Leite, Sandra Hermelijn, Merril Wongsokarijo, Marja Van Eer, Silvia Marques Da Silva, Maurimelia Mesquita Da Costa, Marizette Silva, Maria Calvacante, Terezinha do Menino Jesus Silva Leitao, Beatriz L. Gómez, Angela Restrepo, Angela Tobon, Cristina E. Canteros, Christine Aznar, Denis Blanchet, Vincent Vantilcke, Cyrille Vautrin, Rachida Boukhari, Tom Chiller, Christina Scheel, Angela Ahlquist, Monika Roy, Olivier Lortholary, Bernard Carme, Pierre Couppié, Stephen Vreden

PLOS Neglected Tropical Diseases: published November 21, 2013 | https://doi.org/10.1371/journal.pntd.0002319

Risk Factors for Disseminated Histoplasmosis in a Cohort of HIV-Infected Patients in French Guiana

Viewpoints

NTDs V.2.0: "Blue Marble Health"—Neglected Tropical Disease Control and Elimination in a Shifting Health Policy Landscape

Peter J. Hotez

PLOS Neglected Tropical Diseases: published November 21, 2013 | https://doi.org/10.1371/journal.pntd.0002570

Leveraging Information Technology to Improve Control of Neglected Tropical Diseases

Rajesh Gupta, Paul H. Wise

PLOS Neglected Tropical Diseases: published November 7, 2013 | https://doi.org/10.1371/journal.pntd.0002353

Policy Platform

Developing Eradication Investment Cases for Onchocerciasis, Lymphatic Filariasis, and Human African Trypanosomiasis: Rationale and Main Challenges

Fabrizio Tediosi, Peter Steinmann, Don de Savigny, Marcel Tanner

PLOS Neglected Tropical Diseases: published November 7, 2013 | https://doi.org/10.1371/journal.pntd.0002446

Historical Profiles and Perspectives

Pioneering Neglected Disease Research in Southern Mexico at the "Dr. Hideyo Noguchi" Regional Research Center

Eric Dumonteil, Miguel Rosado-Vallado, Jorge E. Zavala-Castro

PLOS Neglected Tropical Diseases: published November 21, 2013 | https://doi.org/10.1371/journal.pntd.0002530

Reviews

A Review of Factors That Influence Individual Compliance with Mass Drug Administration for Elimination of Lymphatic Filariasis

Alison Krentel, Peter U. Fischer, Gary J. Weil

PLOS Neglected Tropical Diseases: published November 21, 2013 | https://doi.org/10.1371/journal.pntd.0002447

Understanding the Persistence of Plague Foci in Madagascar

Voahangy Andrianaivoarimanana, Katharina Kreppel, Nohal Elissa, Jean-Marc Duplantier, Elisabeth Carniel, Minoarisoa Rajerison, Ronan Jambou

PLOS Neglected Tropical Diseases: published November 7, 2013 | https://doi.org/10.1371/journal.pntd.0002382

A Scientometric Evaluation of the Chagas Disease Implementation Research Programme of the PAHO and TDR

Ana Laura Carbajal-de-la-Fuente, Zaida E. Yadón

PLOS Neglected Tropical Diseases: published November 7, 2013 | https://doi.org/10.1371/journal.pntd.0002445

Research Articles

Whole Genome Sequencing of Field Isolates Reveals a Common Duplication of the Duffy Binding Protein Gene in Malagasy Plasmodium vivax Strains

Didier Menard, Ernest R. Chan, Christophe Benedet, Arsène Ratsimbasoa, Saorin Kim, Pheaktra Chim, Catherine Do, Benoit Witkowski, Remy Durand, Marc Thellier, Carlo Severini, Eric Legrand, Lise Musset, Bakri Y. M. Nour, Odile Mercereau-Puijalon, David Serre, Peter A. Zimmerman

PLOS Neglected Tropical Diseases: published November 21, 2013 | https://doi.org/10.1371/journal.pntd.0002489

Isolation of Saint Louis Encephalitis Virus from a Horse with Neurological Disease in Brazil

Roberta Rosa, Erica Azevedo Costa, Rafael Elias Marques, Taismara Simas Oliveira, Ronaldo Furtini, Maria Rosa Quaresma Bomfim, Mauro Martins Teixeira, Tatiane Alves Paixão, Renato Lima Santos

PLOS Neglected Tropical Diseases: published November 21, 2013 | https://doi.org/10.1371/journal.pntd.0002537

Severe South American Ocular Toxoplasmosis Is Associated with Decreased Ifn-γ/Il-17a and Increased Il-6/Il-13 Intraocular Levels

Alejandra de-la-Torre, Arnaud Sauer, Alexander W. Pfaff, Tristan Bourcier, Julie Brunet, Claude Speeg-Schatz, Laurent Ballonzoli, Odile Villard, Daniel Ajzenberg, Natarajan Sundar, Michael E. Grigg, Jorge E. Gomez-Marin, Ermanno Candolfi

PLOS Neglected Tropical Diseases: published November 21, 2013 | https://doi.org/10.1371/journal.pntd.0002541

Molecular Cloning and Characterization of Taurocyamine Kinase from Clonorchis sinensis: A Candidate Chemotherapeutic Target

Jing-ying Xiao, Ji-Yun Lee, Shinji Tokuhiro, Mitsuru Nagataki, Blanca R. Jarilla, Haruka Nomura, Tae Im Kim, Sung-Jong Hong, Takeshi Agatsuma

PLOS Neglected Tropical Diseases: published November 21, 2013 | https://doi.org/10.1371/journal.pntd.0002548

Fascioliasis and Intestinal Parasitoses Affecting Schoolchildren in Atlixco, Puebla State, Mexico: Epidemiology and Treatment with Nitazoxanide

José Lino Zumaquero-Ríos, Jorge Sarracent-Pérez, Raúl Rojas-García, Lázara Rojas-Rivero, Yaneth Martínez-Tovilla, María Adela Valero, Santiago Mas-Coma

PLOS Neglected Tropical Diseases: published November 21, 2013 | https://doi.org/10.1371/journal.pntd.0002553

Ultra-Deep Sequencing of Intra-host Rabies Virus Populations during Cross-species Transmission

Monica K. Borucki, Haiyin Chen-Harris, Victoria Lao, Gilda Vanier, Debra A. Wadford, Sharon Messenger, Jonathan E. Allen

PLOS Neglected Tropical Diseases: published November 21, 2013 | https://doi.org/10.1371/journal.pntd.0002555

Recent Emergence and Spread of an Arctic-Related Phylogenetic Lineage of Rabies Virus in Nepal

Ganesh R. Pant, Rachel Lavenir, Frank Y. K. Wong, Andrea Certoma, Florence Larrous, Dwij R. Bhatta, Hervé Bourhy, Vittoria Stevens, Laurent Dacheux

PLOS Neglected Tropical Diseases: published November 21, 2013 | https://doi.org/10.1371/journal.pntd.0002560

Gene Amplification and Point Mutations in Pyrimidine Metabolic Genes in 5-Fluorouracil Resistant Leishmania infantum

Jean-François Ritt, Frédéric Raymond, Philippe Leprohon, Danielle Légaré, Jacques Corbeil, Marc Ouellette

PLOS Neglected Tropical Diseases: published November 21, 2013 | https://doi.org/10.1371/journal.pntd.0002564

Highly Sensitive In Vivo Imaging of Trypanosoma brucei Expressing "Red-Shifted" Luciferase

Alex P. McLatchie, Hollie Burrell-Saward, Elmarie Myburgh, Michael D. Lewis, Theresa H. Ward, Jeremy C. Mottram, Simon L. Croft, John M. Kelly, Martin C. Taylor

PLOS Neglected Tropical Diseases: published November 21, 2013 | https://doi.org/10.1371/journal.pntd.0002571

Cholera Vaccination Campaign Contributes to Improved Knowledge Regarding Cholera and Improved Practice Relevant to Waterborne Disease in Rural Haiti

Omowunmi Aibana, Molly Franke, Jessica Teng, Johanne Hilaire, Max Raymond, Louise C. Ivers

PLOS Neglected Tropical Diseases: published November 21, 2013 | https://doi.org/10.1371/journal.pntd.0002576

Correction: Cholera Vaccination Campaign Contributes to Improved Knowledge Regarding Cholera and Improved Practice Relevant to Waterborne Disease in Rural Haiti

Trypanosoma cruzi Disrupts Thymic Homeostasis by Altering Intrathymic and Systemic Stress-Related Endocrine Circuitries

Ailin Lepletier, Vinicius Frias de Carvalho, Patricia Machado Rodrigues e Silva, Silvina Villar, Ana Rosa Pérez, Wilson Savino, Alexandre Morrot

PLOS Neglected Tropical Diseases: published November 14, 2013 | https://doi.org/10.1371/journal.pntd.0002470

Naturally Acquired Immune Responses to P. vivax Merozoite Surface Protein 3α and Merozoite Surface Protein 9 Are Associated with Reduced Risk of P. vivax Malaria in Young Papua New Guinean Children

Danielle I. Stanisic, Sarah Javati, Benson Kiniboro, Enmoore Lin, Jianlin Jiang, Balwan Singh, Esmeralda V. S. Meyer, Peter Siba, Cristian Koepfli, Ingrid Felger, Mary R. Galinski, Ivo Mueller

PLOS Neglected Tropical Diseases: published November 14, 2013 | https://doi.org/10.1371/journal.pntd.0002498

Regulation of Mycolactone, the Mycobacterium ulcerans Toxin, Depends on Nutrient Source

Caroline Deshayes, Shiva Kumar Angala, Estelle Marion, Irène Brandli, Jérémie Babonneau, Laurent Preisser, Sara Eyangoh, Yves Delneste, Pierre Legras, Chantal De Chastellier, Timothy P. Stinear, Mary Jackson, Laurent Marsollier

PLOS Neglected Tropical Diseases: published November 14, 2013 | https://doi.org/10.1371/journal.pntd.0002502

The Effects of Weather and Climate Change on Dengue

Felipe J. Colón-González, Carlo Fezzi, Iain R. Lake, Paul R. Hunter

PLOS Neglected Tropical Diseases: published November 14, 2013 | https://doi.org/10.1371/journal.pntd.0002503

Data-Driven Modeling to Assess Receptivity for Rift Valley Fever Virus

Christopher M. Barker, Tianchan Niu, William K. Reisen, David M. Hartley

PLOS Neglected Tropical Diseases: published November 14, 2013 | https://doi.org/10.1371/journal.pntd.0002515

Population Genetics of Trypanosoma brucei rhodesiense: Clonality and Diversity within and between Foci

Craig W. Duffy, Lorna MacLean, Lindsay Sweeney, Anneli Cooper, C. Michael R. Turner, Andy Tait, Jeremy Sternberg, Liam J. Morrison, Annette MacLeod

PLOS Neglected Tropical Diseases: published November 14, 2013 | https://doi.org/10.1371/journal.pntd.0002526

Fecal Occult Blood and Fecal Calprotectin as Point-of-Care Markers of Intestinal Morbidity in Ugandan Children with Schistosoma mansoni Infection

Amaya L. Bustinduy, José C. Sousa-Figueiredo, Moses Adriko, Martha Betson, Alan Fenwick, Narcis Kabatereine, J. Russell Stothard

PLOS Neglected Tropical Diseases: published November 14, 2013 | https://doi.org/10.1371/journal.pntd.0002542

Trypanosoma cruzi TcSMUG L-surface Mucins Promote Development and Infectivity in the Triatomine Vector Rhodnius prolixus

Marcelo S. Gonzalez, Marcela S. Souza, Eloi S. Garcia, Nadir F. S. Nogueira, Cícero B. Mello, Gaspar E. Cánepa, Santiago Bertotti, Ignacio M. Durante, Patrícia Azambuja, Carlos A. Buscaglia

PLOS Neglected Tropical Diseases: published November 14, 2013 | https://doi.org/10.1371/journal.pntd.0002552

Genomic Characterisation of Invasive Non-Typhoidal Salmonella enterica Subspecies enterica Serovar Bovismorbificans Isolates from Malawi

Christina Bronowski, Maria C. Fookes, Ruth Gilderthorp, Kevin E. Ashelford, Simon R. Harris, Amos Phiri, Neil Hall, Melita A. Gordon, John Wain, Charles A. Hart, Paul Wigley, Nicholas R. Thomson, Craig Winstanley

PLOS Neglected Tropical Diseases: published November 14, 2013 | https://doi.org/10.1371/journal.pntd.0002557

High Prevalence of Cysticercosis in People with Epilepsy in Southern Rwanda

Ruth Rottbeck, Jules Fidèle Nshimiyimana, Pierrot Tugirimana, Uta E. Düll, Janko Sattler, Jean-Claudien Hategekimana, Janvier Hitayezu, Irmengard Bruckmaier, Matthias Borchert, Jean Bosco Gahutu, Sebastian Dieckmann, Gundel Harms, Frank P. Mockenhaupt, Ralf Ignatius

PLOS Neglected Tropical Diseases: published November 14, 2013 | https://doi.org/10.1371/journal.pntd.0002558

Resistance of M. leprae to Quinolones: A Question of Relativity?

Nicolas Veziris, Aurélie Chauffour, Sylvie Escolano, Sarah Henquet, Masanori Matsuoka, Vincent Jarlier, Alexandra Aubry

PLOS Neglected Tropical Diseases: published November 14, 2013 | https://doi.org/10.1371/journal.pntd.0002559

The Improbable Transmission of Trypanosoma cruzi to Human: The Missing Link in the Dynamics and Control of Chagas Disease

Pierre Nouvellet, Eric Dumonteil, Sébastien Gourbière

PLOS Neglected Tropical Diseases: published November 7, 2013 | https://doi.org/10.1371/journal.pntd.0002505

The Burden of Rabies in Tanzania and Its Impact on Local Communities

Maganga Sambo, Sarah Cleaveland, Heather Ferguson, Tiziana Lembo, Cleophas Simon, Honorati Urassa, Katie Hampson

PLOS Neglected Tropical Diseases: published November 7, 2013 | https://doi.org/10.1371/journal.pntd.0002510

The Impact of Climatic Risk Factors on the Prevalence, Distribution, and Severity of Acute and Chronic Trachoma

Anita Ramesh, Sari Kovats, Dominic Haslam, Elena Schmidt, Clare E. Gilbert

PLOS Neglected Tropical Diseases: published November 7, 2013 | https://doi.org/10.1371/journal.pntd.0002513

An Aspartic Protease of the Scabies Mite Sarcoptes scabiei Is Involved in the Digestion of Host Skin and Blood Macromolecules

Wajahat Mahmood, Linda T. Viberg, Katja Fischer, Shelley F. Walton, Deborah C. Holt

PLOS Neglected Tropical Diseases: published November 7, 2013 | https://doi.org/10.1371/journal.pntd.0002525

Regulatory T Cells in Peripheral Blood and Cerebrospinal Fluid of Syphilis Patients with and without Neurological Involvement

Kang Li, Cuini Wang, Haikong Lu, Xin Gu, Zhifang Guan, Pingyu Zhou

PLOS Neglected Tropical Diseases: published November 7, 2013 | https://doi.org/10.1371/journal.pntd.0002528

Combinatory Microarray and SuperSAGE Analyses Identify Pairing-Dependently Transcribed Genes in Schistosoma mansoni Males, Including Follistatin

Silke Leutner, Katia C. Oliveira, Björn Rotter, Svenja Beckmann, Christin Buro, Steffen Hahnel, Joao P. Kitajima, Sergio Verjovski-Almeida, Peter Winter, Christoph G. Grevelding

PLOS Neglected Tropical Diseases: published November 7, 2013 | https://doi.org/10.1371/journal.pntd.0002532

Preclinical Evaluation of the Immunogenicity and Safety of an Inactivated Enterovirus 71 Candidate Vaccine

Shi-Hsia Hwa, Yock Ann Lee, Joseph N. Brewoo, Charalambos D. Partidos, Jorge E. Osorio, Joseph D. Santangelo

PLOS Neglected Tropical Diseases: published November 7, 2013 | https://doi.org/10.1371/journal.pntd.0002538

A Population Growth Trend Analysis for Neotricula aperta, the Snail Intermediate Host of Schistosoma mekongi, after Construction of the Pak-Mun Dam

Stephen W. Attwood, E. Suchart Upatham

PLOS Neglected Tropical Diseases: published November 7, 2013 | https://doi.org/10.1371/journal.pntd.0002539