July 2013

Cover

The Pantanal

This image shows a classic workday in the wetlands of the Brazilian Pantanal. It represents the harmony between the cordial people of Pantanal and one of the largest freshwater wetlands in the world. See Pauvolid-Corrêa et al.

This is an open-access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication.

Image Credit: Alex Pauvolid-Corrêa

Editorial

NTDs in the Heart of Darkness: The Democratic Republic of Congo's Unknown Burden of Neglected Tropical Diseases

Anne W. Rimoin, Peter J. Hotez

PLOS Neglected Tropical Diseases: published July 25, 2013 | https://doi.org/10.1371/journal.pntd.0002118

Viewpoints

Linking Environmental Drivers to Infectious Diseases: The European Environment and Epidemiology Network

Jan C. Semenza, Bertrand Sudre, Tolu Oni, Jonathan E. Suk, Johan Giesecke

PLOS Neglected Tropical Diseases: published July 25, 2013 | https://doi.org/10.1371/journal.pntd.0002323

Has the NTD Community Neglected Evidence-Based Policy?

Sukrti Nagpal, David Sinclair, Paul Garner

PLOS Neglected Tropical Diseases: published July 11, 2013 | https://doi.org/10.1371/journal.pntd.0002238

Taenia solium Cysticercosis: The Case of Cuba

Kirezi Kanobana, Aniran Ruiz, Lazara Rojas, Rene Andrade, Felix Rosado, Katja Polman, Fidel Angel Núñez

PLOS Neglected Tropical Diseases: published July 11, 2013 | https://doi.org/10.1371/journal.pntd.0002202

Expert Commentary

Has the NTD Community Neglected Evidence-Based Policy? PLOS NTDs 2013 Expert Commentary of the Viewpoint by Nagpal S, Sinclair D, Garner P

Antonio Montresor, Albis F. Gabrielli, Dirk Engels, Denis Daumerie, Lorenzo Savioli

PLOS Neglected Tropical Diseases: published July 11, 2013 | https://doi.org/10.1371/journal.pntd.0002299

Review

Efficacy and Safety of Anthelmintics Tested against Taenia solium Cysticercosis in Pigs

Ernatus Martin Mkupasi, Chummy Sikalizyo Sikasunge, Helena Aminiel Ngowi, Maria Vang Johansen

PLOS Neglected Tropical Diseases: published July 25, 2013 | https://doi.org/10.1371/journal.pntd.0002200

Research Articles

Immune Response to Snake Envenoming and Treatment with Antivenom; Complement Activation, Cytokine Production and Mast Cell Degranulation

Shelley F. Stone, Geoffrey K. Isbister, Seyed Shahmy, Fahim Mohamed, Chandana Abeysinghe, Harendra Karunathilake, Ariaranee Ariaratnam, Tamara E. Jacoby-Alner, Claire L. Cotterell, Simon G. A. Brown

PLOS Neglected Tropical Diseases: published July 25, 2013 | https://doi.org/10.1371/journal.pntd.0002326

Dengue and Other Common Causes of Acute Febrile Illness in Asia: An Active Surveillance Study in Children

Maria Rosario Capeding, Mary Noreen Chua, Sri Rezeki Hadinegoro, Ismail I. H. M. Hussain, Revathy Nallusamy, Punnee Pitisuttithum, Kusnandi Rusmil, Usa Thisyakorn, Stephen J. Thomas, Ngoc Huu Tran, Dewa Nyoman Wirawan, In-Kyu Yoon, Alain Bouckenooghe, Yanee Hutagalung, Thelma Laot, Tram Anh Wartel

PLOS Neglected Tropical Diseases: published July 25, 2013 | https://doi.org/10.1371/journal.pntd.0002331

Whole-Organ Isolation Approach as a Basis for Tissue-Specific Analyses in Schistosoma mansoni

Steffen Hahnel, Zhigang Lu, R. Alan Wilson, Christoph G. Grevelding, Thomas Quack

PLOS Neglected Tropical Diseases: published July 25, 2013 | https://doi.org/10.1371/journal.pntd.0002336

Correction: Whole-Organ Isolation Approach as a Basis for Tissue-Specific Analyses in Schistosoma mansoni

Association between Ocular Bacterial Carriage and Follicular Trachoma Following Mass Azithromycin Distribution in The Gambia

Sarah E. Burr, John D. Hart, Tansy Edwards, Ignatius Baldeh, Ebrima Bojang, Emma M. Harding-Esch, Martin J. Holland, Thomas M. Lietman, Sheila K. West, David C. W. Mabey, Ansumana Sillah, Robin L. Bailey

PLOS Neglected Tropical Diseases: published July 25, 2013 | https://doi.org/10.1371/journal.pntd.0002347

Chikungunya Virus Infection Results in Higher and Persistent Viral Replication in Aged Rhesus Macaques Due to Defects in Anti-Viral Immunity

Ilhem Messaoudi, Jennifer Vomaske, Thomas Totonchy, Craig N. Kreklywich, Kristen Haberthur, Laura Springgay, James D. Brien, Michael S. Diamond, Victor R. DeFilippis, Daniel N. Streblow

PLOS Neglected Tropical Diseases: published July 25, 2013 | https://doi.org/10.1371/journal.pntd.0002343

Dried-Blood Spots: A Cost-Effective Field Method for the Detection of Chikungunya Virus Circulation in Remote Areas

Soa Fy Andriamandimby, Jean-Michel Heraud, Laurence Randrianasolo, Jean Théophile Rafisandratantsoa, Seta Andriamamonjy, Vincent Richard

PLOS Neglected Tropical Diseases: published July 25, 2013 | https://doi.org/10.1371/journal.pntd.0002339

Validation of a Remote Sensing Model to Identify Simulium damnosum s.l. Breeding Sites in Sub-Saharan Africa

Benjamin G. Jacob, Robert J. Novak, Laurent D. Toe, Moussa Sanfo, Daniel A. Griffith, Thomson L. Lakwo, Peace Habomugisha, Moses N. Katabarwa, Thomas R. Unnasch

PLOS Neglected Tropical Diseases: published July 25, 2013 | https://doi.org/10.1371/journal.pntd.0002342

The Schistosome Oesophageal Gland: Initiator of Blood Processing

Xiao-Hong Li, William de Castro-Borges, Sophie Parker-Manuel, Gillian M. Vance, Ricardo DeMarco, Leandro X. Neves, Gareth J. O. Evans, R. Alan Wilson

PLOS Neglected Tropical Diseases: published July 25, 2013 | https://doi.org/10.1371/journal.pntd.0002337

CD4+ Th17 Cells Discriminate Clinical Types and Constitute a Third Subset of Non Th1, Non Th2 T Cells in Human Leprosy

Chaman Saini, V. Ramesh, Indira Nath

PLOS Neglected Tropical Diseases: published July 25, 2013 | https://doi.org/10.1371/journal.pntd.0002338

Polyethyleneimine Mediated DNA Transfection in Schistosome Parasites and Regulation of the WNT Signaling Pathway by a Dominant-Negative SmMef2

Shuang Liang, Matty Knight, Emmitt R. Jolly

PLOS Neglected Tropical Diseases: published July 25, 2013 | https://doi.org/10.1371/journal.pntd.0002332

Immunological Profile of HTLV-1-Infected Patients Associated with Infectious or Autoimmune Dermatological Disorders

Jordana Grazziela Alves Coelho-dos-Reis, Livia Passos, Mariana Costa Duarte, Marcelo Grossi Araújo, Ana Carolina Campi-Azevedo, Andréa Teixeira-Carvalho, Vanessa Peruhype-Magalhães, Bruno Caetano Trindade, Raquel dos Santos Dias, Marina Lobato Martins, Anna Barbara de Freitas Carneiro-Proietti, Antônio Carlos Guedes, Denise Utsch Gonçalves, Olindo Assis Martins-Filho

PLOS Neglected Tropical Diseases: published July 25, 2013 | https://doi.org/10.1371/journal.pntd.0002328

Spatially Explicit Modeling of Schistosomiasis Risk in Eastern China Based on a Synthesis of Epidemiological, Environmental and Intermediate Host Genetic Data

Matthias Schrader, Torsten Hauffe, Zhijie Zhang, George M. Davis, Fred Jopp, Justin V. Remais, Thomas Wilke

PLOS Neglected Tropical Diseases: published July 25, 2013 | https://doi.org/10.1371/journal.pntd.0002327

TLR9 Activation Dampens the Early Inflammatory Response to Paracoccidioides brasiliensis, Impacting Host Survival

João Filipe Menino, Margarida Saraiva, Ana G. Gomes-Alves, Diogo Lobo-Silva, Mark Sturme, Jéssica Gomes-Rezende, Ana Laura Saraiva, Gustavo H. Goldman, Cristina Cunha, Agostinho Carvalho, Luigina Romani, Jorge Pedrosa, António Gil Castro, Fernando Rodrigues

PLOS Neglected Tropical Diseases: published July 25, 2013 | https://doi.org/10.1371/journal.pntd.0002317

A Very High Infection Intensity of Schistosoma mansoni in a Ugandan Lake Victoria Fishing Community Is Required for Association with Highly Prevalent Organ Related Morbidity

Edridah M. Tukahebwa, Pascal Magnussen, Henry Madsen, Narcis B. Kabatereine, Fred Nuwaha, Shona Wilson, Birgitte J. Vennervald

PLOS Neglected Tropical Diseases: published July 25, 2013 | https://doi.org/10.1371/journal.pntd.0002268

Occurrence of Nontuberculous Mycobacterial Pulmonary Infection in an Endemic Area of Tuberculosis

Ana Roberta Fusco da Costa, Joseph O. Falkinham III, Maria Luiza Lopes, Adriana Rodrigues Barretto, João Soares Felicio, Lúcia Helena Messias Sales, Jeann Ricardo da Costa Bahia, Emilyn Costa Conceição, Karla Valéria Batista Lima

PLOS Neglected Tropical Diseases: published July 18, 2013 | https://doi.org/10.1371/journal.pntd.0002340

Etiology of Severe Non-malaria Febrile Illness in Northern Tanzania: A Prospective Cohort Study

John A. Crump, Anne B. Morrissey, William L. Nicholson, Robert F. Massung, Robyn A. Stoddard, Renee L. Galloway, Eng Eong Ooi, Venance P. Maro, Wilbrod Saganda, Grace D. Kinabo, Charles Muiruri, John A. Bartlett

PLOS Neglected Tropical Diseases: published July 18, 2013 | https://doi.org/10.1371/journal.pntd.0002324

rKLO8, a Novel Leishmania donovani – Derived Recombinant Immunodominant Protein for Sensitive Detection of Visceral Leishmaniasis in Sudan

Elfadil Abass, Nadine Bollig, Katharina Reinhard, Bärbel Camara, Durria Mansour, Alexander Visekruna, Michael Lohoff, Ulrich Steinhoff

PLOS Neglected Tropical Diseases: published July 18, 2013 | https://doi.org/10.1371/journal.pntd.0002322

Evaluation of a Typhoid/Paratyphoid Diagnostic Assay (TPTest) Detecting Anti-Salmonella IgA in Secretions of Peripheral Blood Lymphocytes in Patients in Dhaka, Bangladesh

Farhana Khanam, Alaullah Sheikh, Md. Abu Sayeed, Md. Saruar Bhuiyan, Feroza Kaneez Choudhury, Umme Salma, Shahnaz Pervin, Tania Sultana, Dilruba Ahmed, Doli Goswami, Md. Lokman Hossain, K. Z. Mamun, Richelle C. Charles, W. Abdullah Brooks, Stephen B. Calderwood, Alejandro Cravioto, Edward T. Ryan, Firdausi Qadri

PLOS Neglected Tropical Diseases: published July 11, 2013 | https://doi.org/10.1371/journal.pntd.0002316

Ilheus Virus Isolation in the Pantanal, West-Central Brazil

Alex Pauvolid-Corrêa, Joan L. Kenney, Dinair Couto-Lima, Zilca M. S. Campos, Hermann G. Schatzmayr, Rita M. R. Nogueira, Aaron C. Brault, Nicholas Komar

PLOS Neglected Tropical Diseases: published July 18, 2013 | https://doi.org/10.1371/journal.pntd.0002318

Correction: Ilheus Virus Isolation in the Pantanal, West-Central Brazil

Mycobacterium ulcerans Disease: Experience with Primary Oral Medical Therapy in an Australian Cohort

N. Deborah Friedman, Eugene Athan, Andrew J. Hughes, Masoomeh Khajehnoori, Anthony McDonald, Peter Callan, Richard Rahdon, Daniel P. O'Brien

PLOS Neglected Tropical Diseases: published July 18, 2013 | https://doi.org/10.1371/journal.pntd.0002315

Hemostatic Dysfunction Is Increased in Patients with Hepatosplenic Schistosomiasis Mansoni and Advanced Periportal Fibrosis

Luiz Arthur Calheiros Leite, Adenor Almeida Pimenta Filho, Caíque Silveira Martins da Fonseca, Bianka Santana dos Santos, Rita de Cássia dos Santos Ferreira, Silvia Maria Lucena Montenegro, Edmundo Pessoa Lopes, Ana Lúcia Coutinho Domingues, James Stuart Owen, Vera Lúcia de Menezes Lima

PLOS Neglected Tropical Diseases: published July 18, 2013 | https://doi.org/10.1371/journal.pntd.0002314

Molecular Identification of Echinococcus multilocularis Infection in Small Mammals from Northeast, Iran

Molouk Beiromvand, Lame Akhlaghi, Seyed Hossein Fattahi Massom, Ahmad Reza Meamar, Jamshid Darvish, Elham Razmjou

PLOS Neglected Tropical Diseases: published July 11, 2013 | https://doi.org/10.1371/journal.pntd.0002313

Exploring Gender Dimensions of Treatment Programmes for Neglected Tropical Diseases in Uganda

Heather Rilkoff, Edridah Muheki Tukahebwa, Fiona M. Fleming, Jacqueline Leslie, Donald C. Cole

PLOS Neglected Tropical Diseases: published July 11, 2013 | https://doi.org/10.1371/journal.pntd.0002312

Health Beliefs and Practices Related to Dengue Fever: A Focus Group Study

Li Ping Wong, Sazaly AbuBakar

PLOS Neglected Tropical Diseases: published July 11, 2013 | https://doi.org/10.1371/journal.pntd.0002310

Analytical and Clinical Performance of the CDC Real Time RT-PCR Assay for Detection and Typing of Dengue Virus

Gilberto A. Santiago, Edgardo Vergne, Yashira Quiles, Joan Cosme, Jesus Vazquez, Juan F. Medina, Freddy Medina, Candimar Colón, Harold Margolis, Jorge L. Muñoz-Jordán

PLOS Neglected Tropical Diseases: published July 11, 2013 | https://doi.org/10.1371/journal.pntd.0002311

Correction: Analytical and Clinical Performance of the CDC Real Time RT-PCR Assay for Detection and Typing of Dengue Virus

Population Genetics of the Filarial Worm Wuchereria bancrofti in a Post-treatment Region of Papua New Guinea: Insights into Diversity and Life History

Scott T. Small, Akshaya Ramesh, Krufinta Bun, Lisa Reimer, Edward Thomsen, Manasseh Baea, Moses J. Bockarie, Peter Siba, James W. Kazura, Daniel J. Tisch, Peter A. Zimmerman

PLOS Neglected Tropical Diseases: published July 11, 2013 | https://doi.org/10.1371/journal.pntd.0002308

A Single Immunization with MVA Expressing GnGc Glycoproteins Promotes Epitope-specific CD8+-T Cell Activation and Protects Immune-competent Mice against a Lethal RVFV Infection

Elena López-Gil, Gema Lorenzo, Esther Hevia, Belén Borrego, Martin Eiden, Martin Groschup, Sarah C. Gilbert, Alejandro Brun

PLOS Neglected Tropical Diseases: published July 11, 2013 | https://doi.org/10.1371/journal.pntd.0002309

Cathelicidin-like Helminth Defence Molecules (HDMs): Absence of Cytotoxic, Anti-microbial and Anti-protozoan Activities Imply a Specific Adaptation to Immune Modulation

Karine Thivierge, Sophie Cotton, Deborah A. Schaefer, Michael W. Riggs, Joyce To, Maria E. Lund, Mark W. Robinson, John P. Dalton, Sheila M. Donnelly

PLOS Neglected Tropical Diseases: published July 11, 2013 | https://doi.org/10.1371/journal.pntd.0002307

Overexpression of the Endothelial Protein C Receptor Is Detrimental during Pneumonia-Derived Gram-negative Sepsis (Melioidosis)

Liesbeth M. Kager, Marcel Schouten, W. Joost Wiersinga, J. Daan de Boer, Lionel C. W. Lattenist, Joris J. T. H. Roelofs, Joost C. M. Meijers, Marcel Levi, Arjen M. Dondorp, Charles T. Esmon, Cornelis van 't Veer, Tom van der Poll

PLOS Neglected Tropical Diseases: published July 11, 2013 | https://doi.org/10.1371/journal.pntd.0002306

Identification of Tsetse (Glossina spp.) Using Matrix-Assisted Laser Desorption/Ionisation Time of Flight Mass Spectrometry

Antje Hoppenheit, Jayaseelan Murugaiyan, Burkhard Bauer, Stephan Steuber, Peter-Henning Clausen, Uwe Roesler

PLOS Neglected Tropical Diseases: published July 11, 2013 | https://doi.org/10.1371/journal.pntd.0002305

Achievements and Challenges upon the Implementation of a Program for National Control of Congenital Chagas in Bolivia: Results 2004–2009

Cristina Alonso-Vega, Claire Billot, Faustino Torrico

PLOS Neglected Tropical Diseases: published July 11, 2013 | https://doi.org/10.1371/journal.pntd.0002304

Assessment of Transmission in Trachoma Programs over Time Suggests No Short-Term Loss of Immunity

Fengchen Liu, Travis C. Porco, Kathryn J. Ray, Robin L. Bailey, Harran Mkocha, Beatriz Muñoz, Thomas C. Quinn, Thomas M. Lietman, Sheila K. West

PLOS Neglected Tropical Diseases: published July 11, 2013 | https://doi.org/10.1371/journal.pntd.0002303

Correction: Assessment of Transmission in Trachoma Programs over Time Suggests No Short-Term Loss of Immunity

Sequential Waves of Gene Expression in Patients with Clinically Defined Dengue Illnesses Reveal Subtle Disease Phases and Predict Disease Severity

Peifang Sun, Josefina García, Guillermo Comach, Maryanne T. Vahey, Zhining Wang, Brett M. Forshey, Amy C. Morrison, Gloria Sierra, Isabel Bazan, Claudio Rocha, Stalin Vilcarromero, Patrick J. Blair, Thomas W. Scott, Daria E. Camacho, Christian F. Ockenhouse, Eric S. Halsey, Tadeusz J. Kochel

PLOS Neglected Tropical Diseases: published July 11, 2013 | https://doi.org/10.1371/journal.pntd.0002298

Molecular Epidemiology Reveals Genetic Diversity amongst Isolates of the Cryptococcus neoformans/C. gattii Species Complex in Thailand

Sirada Kaocharoen, Popchai Ngamskulrungroj, Carolina Firacative, Luciana Trilles, Dumrongdej Piyabongkarn, Wijit Banlunara, Natteewan Poonwan, Angkana Chaiprasert, Wieland Meyer, Ariya Chindamporn

PLOS Neglected Tropical Diseases: published July 4, 2013 | https://doi.org/10.1371/journal.pntd.0002297

The Use of NanoTrap Particles as a Sample Enrichment Method to Enhance the Detection of Rift Valley Fever Virus

Nazly Shafagati, Aarthi Narayanan, Alan Baer, Katherine Fite, Chelsea Pinkham, Charles Bailey, Fatah Kashanchi, Benjamin Lepene, Kylene Kehn-Hall

PLOS Neglected Tropical Diseases: published July 4, 2013 | https://doi.org/10.1371/journal.pntd.0002296

Transcriptomic Profiling of Diverse Aedes aegypti Strains Reveals Increased Basal-level Immune Activation in Dengue Virus-refractory Populations and Identifies Novel Virus-vector Molecular Interactions

Shuzhen Sim, Natapong Jupatanakul, José L. Ramirez, Seokyoung Kang, Claudia M. Romero-Vivas, Hamish Mohammed, George Dimopoulos

PLOS Neglected Tropical Diseases: published July 4, 2013 | https://doi.org/10.1371/journal.pntd.0002295

Field Evaluation of the Cepheid GeneXpert Chlamydia trachomatis Assay for Detection of Infection in a Trachoma Endemic Community in Tanzania

Alexander Jenson, Laura Dize, Harran Mkocha, Beatriz Munoz, Jennifer Lee, Charlotte Gaydos, Thomas Quinn, Sheila K. West

PLOS Neglected Tropical Diseases: published July 4, 2013 | https://doi.org/10.1371/journal.pntd.0002265

Cover

The Pantanal

Editorial

Viewpoints

Expert Commentary

Review

Research Articles

Related Articles

Related Articles

Related Articles

Related Articles