Open Access

Peer-reviewed

A Phase 2a randomized, single-center, double-blind, placebo-controlled study to evaluate the safety and preliminary efficacy of oral iOWH032 against cholera diarrhea in a controlled human infection model

• Rahsan Erdem ,

  Contributed equally to this work with: Rahsan Erdem, Gwen Ambler

  Roles Investigation, Methodology, Writing – original draft, Writing – review & editing

  Affiliation PATH, Seattle, Washington, United States of America

  ORCID logo https://orcid.org/0000-0002-4397-2606

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• Gwen Ambler ,

  Contributed equally to this work with: Rahsan Erdem, Gwen Ambler

  Roles Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

  Current address: Opticyte, Inc., Seattle, Washington, United States of America

  Affiliation PATH, Seattle, Washington, United States of America

  ORCID logo https://orcid.org/0000-0003-1992-6607

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• Mohamed Al-Ibrahim,

  Roles Investigation, Methodology, Writing – review & editing

  Affiliation Pharmaron, Baltimore, Maryland, United States of America

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• Katarzyna Fraczek,

  Roles Investigation

  Affiliation Pharmaron, Baltimore, Maryland, United States of America

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• Steven D. Dong,

  Roles Investigation

  Affiliation PATH, Seattle, Washington, United States of America

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• Christopher Gast,

  Roles Investigation, Methodology

  Affiliation PATH, Seattle, Washington, United States of America

  ORCID logo https://orcid.org/0000-0003-4216-679X

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• Laina D. Mercer,

  Roles Formal analysis, Investigation, Methodology, Writing – review & editing

  Affiliation PATH, Seattle, Washington, United States of America

  ORCID logo https://orcid.org/0000-0002-2517-8900

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• Michael Raine,

  Roles Investigation, Methodology

  Affiliation PATH, Seattle, Washington, United States of America

  ORCID logo https://orcid.org/0000-0001-8396-6748

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• Sharon M. Tennant,

  Roles Investigation, Writing – review & editing

  Affiliation Center for Vaccine Development and Global Health, School of Medicine, University of Maryland, Baltimore, Maryland, United States of America

  ORCID logo https://orcid.org/0000-0002-0651-5748

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• Wilbur H. Chen,

  Roles Investigation, Methodology, Writing – review & editing

  Affiliation Center for Vaccine Development and Global Health, School of Medicine, University of Maryland, Baltimore, Maryland, United States of America

  ORCID logo https://orcid.org/0000-0001-7741-5536

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• Eugenio L. de Hostos,

  Roles Conceptualization, Funding acquisition, Investigation, Methodology, Supervision, Writing – review & editing

  Current address: Lyell Immunopharma, Inc., South San Francisco, California, United States of America

  Affiliation PATH, Seattle, Washington, United States of America

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• Robert K. M. Choy

  Roles Formal analysis, Investigation, Methodology, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: rchoy@path.org

  Affiliation PATH, Seattle, Washington, United States of America

  ORCID logo https://orcid.org/0000-0002-8441-4029

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