The harmful effects of lead poisoning have been well-established since ancient times, with the First Century Roman writer Vitruvius warning of the health hazards of the widely-used metal. Today, we know that "there is almost no function in the human body which is not affected by lead toxicity."

Lead exposure increases deaths from cardiovascular diseases among adults, particularly in low and middle-income countries. The long-term storage of lead in bones can lead to a wide range of health effects, including high blood pressure and renal failure.

For pregnant women and their babies, lead exposure is particularly devastating—it can cross the placental barrier, causing complications of pregnancy, miscarriages, stillbirths, and low birth weight.

In children, lead exposure has long-term and irreversible impacts on mental function reducing educational performance and employment opportunities. Together, these health consequences for individuals compromise the economic growth and social stability of entire countries.

While high income countries have significantly reduced lead exposure through rigorous testing, targeted research, and robust policy interventions, low- and middle-income countries, including several in Asia and the Pacific, continue to grapple with dangerously high levels of lead exposure.

An estimated 95% of the world’s IQ loss and 90% of cardiovascular deaths from exposure to lead is in low and middle-income countries, according to a 2023 study. The economic costs of lead exposure are staggering, with losses in total GDP of 10.5% in East Asia and the Pacific, 9.1% in South Asia, and 8.9% in Sub-Saharan Africa.

With effective interventions, high-income countries have reduced this economic impact of lead exposure to losses of 5.0% of total GDP but have not yet eliminated all sources of lead exposure.

The scale of the challenge is immense. Lead exposure causes three times as many deaths as exposure to unsafe water and sanitation and just as many deaths as air pollution. South Asia has some of the highest blood lead levels in the world with India alone home to 275 million children affected by lead poisoning —this amounts to half of all India’s children and one-third of the children affected by lead globally.

Bangladesh struggles with chronic lead exposure, largely due to contaminated spices, while Afghanistan faces a "silent epidemic" linked to lead-leaching cookware.

In the Philippines, 2021-2022 data from the Expanded National Nutrition Survey shows that over a million Filipino children ages 6-9 years have elevated blood lead levels. In Indonesia, more than 8 million children are estimated to have high blood lead levels with millions more at risk from lead paint covering homes and public facilities.

Across Asia and the Pacific, the informal recycling of used lead-acid batteries continues to poison communities, contaminating air, soil, and water.

The different sources of lead exposure complicate the challenge to remove the problem, however, the scope of the health and socioeconomic damage from lead demands decisive and comprehensive action. But we are not starting from zero.

The evidence base is robust, and the solutions are within reach. What remains is the political will and coordinated action across sectors to implement them effectively. The recent launch of the Partnership for a Lead-Free Future at the United Nations General Assembly marks a watershed moment in the global fight against lead poisoning.

Exposure to lead is one of the most preventable public health threats, and yet it remains a pervasive environmental poison.

Health systems are at the forefront of the response toward a lead-free future.

Developing countries must strengthen health regulatory frameworks and enforce existing standards for lead content in products such as food, cosmetics, paints, and water. Inconsistent enforcement has been a major barrier in reducing exposure, and this must be addressed with urgency.

Stronger regulatory oversight and harsher penalties for non-compliance will be key, particularly in industries known for high lead usage. International development partners, through technical advice and policy-based lending, can play a pivotal role in incentivizing reforms and ensuring their effective implementation.

Building healthcare capacity is crucial. Healthcare professionals have low knowledge of the symptoms of lead poisoning, such as irritability and lethargy in mild doses and tremors and other neuropathies in higher doses.

Training is needed so that health workers identify lead poisoning and provide timely referrals for treatment. Developing the necessary healthcare infrastructure—from rural clinics to urban hospitals—is fundamental to ensuring that testing, treatment, and prevention measures can be implemented from communities, primary care facilities to hospitals.

Health actions should support the establishment of systematic, large-scale testing and data collection systems. Reliable data plays an essential role in understanding the full scope of lead exposure and to inform targeted interventions. Alongside quantitative measurements, the use of qualitative and ethnographic data is invaluable tool to understand how and why lead-contaminated products are used - and who is exposed to them.

Public awareness is critical. Surveys reveal that knowledge about the dangers of lead exposure is shockingly low. Large-scale educational and health promotion campaigns must be launched to raise awareness of the sources and effects of lead poisoning, particularly in communities most at risk.

While the health sector has a role in addressing lead poisoning, whatever the source, the scale and complexity of the problem demands coordinated action well beyond a single sector.

Governments, civil society, multilateral institutions, development agencies and the private sector must all come together to share resources, knowledge, and best practices. Only through collaboration can we hope to reduce and ultimately eliminate lead from our environment. The launch of the Partnership for a Lead-Free Future is a vital step in bringing stakeholders together.

Exposure to lead is one of the most preventable public health threats, and yet it remains a pervasive environmental poison. The science is clear; the solutions are known. A lead-free future is not just a possibility—it is a necessity.

By acting now, we can safeguard the health and potential of millions of children, secure the economic and social well-being of developing countries, and ensure a healthier, brighter Asia and Pacific for generations to come.