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Wound healing. Oral and topical activity of Aloe vera.
The influence of Aloe vera, orally and topically, on wound healing was studied and suggest that A. vera is effective by both oral and topical routes of administration.

Anti-nociceptive action of peripheral mu-opioid receptors by G-beta-gamma protein-mediated inhibition of TRPM3 channels
It is shown in neurons of murine dorsal root ganglia that pro-nociceptive TRPM3 channels, present in the peripheral parts of nociceptors, are strongly inhibited by μOR activation, much more than other TRP channels in the same compartment, like TRPV1 and TRPA1.

Regulation of the transient receptor potential channel TRPM3 by phosphoinositides
TRPM3 is dynamically regulated by plasma membrane PI(4,5)P2 and related PIPs.

Diacylglycerol mediates regulation of TASK potassium channels by Gq-coupled receptors
It is demonstrated that the second messenger lipid diacylglycerol (DAG) gates TASK1/3, defining a new role for DAG in controlling the dynamics of cellular excitability and identifying DAG as the signal regulating TASk channels downstream of GPCRs.

Genetic Evidence for Involvement of Neuronally Expressed S1P1 Receptor in Nociceptor Sensitization and Inflammatory Pain
The data show that neuronally expressed S 1P1 receptors play a significant role in regulating nociceptor function and that S1P/S1P1 signaling may be a key player in the onset of thermal hypersensitivity and hyperalgesia associated with inflammation.

Controlling the Activity of a Phosphatase and Tensin Homolog (PTEN) by Membrane Potential*
Ci-VSPTEN provides a novel approach for studying the complex mechanism of activation, cellular control, and pharmacology of this important tumor suppressor, and is useful for probing the role and specificity of these messengers in many cellular processes and to analyze the timing of phosphoinositide signaling.

A human phospholipid phosphatase activated by a transmembrane control module[S]
It is suggested that the endogenous VSD of hVSP1 is a control module that initiates signaling through the phosphatase domain and indicate a role for VSP-mediated phosphoinositide signaling in mammals.

Direct modulation of TRPM4 and TRPM3 channels by the phospholipase C inhibitor U73122
It is found that the most frequently employed PLC inhibitor, U73122, activates endogenous ionic currents in widely used cell lines and this work sets out to identify these U 73122‐sensitive ion channels.

Chloride – The Underrated Ion in Nociceptors
Chlorine channels as well as mediators that modulate chloride fluxes are regulated in pain disorders and contribute to nociceptor excitation and sensitization it is timely and important to emphasize their critical role in nocICEptive primary afferents in this review.
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