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ASIC3, a sensor of acidic and primary inflammatory pain
It is shown that ∼60% of rat cutaneous sensory neurons express ASIC3‐like currents, and peripheral ASIC3 channels are essential sensors of acidic pain and integrators of molecular signals produced during inflammation where they contribute to primary hyperalgesia.

TREK‐1, a K+ channel involved in polymodal pain perception
It is demonstrated that TREK‐1 qualifies as one of the molecular sensors involved in pain perception and as an attractive target for the development of new analgesics.

The mechano‐activated K+ channels TRAAK and TREK‐1 control both warm and cold perception
The mechano‐gated and highly temperature‐sensitive potassium channels of the TREK/TRAAK family, which normally work as silencers of the excitatory channels, are also implicated, important for the definition of temperature thresholds and temperature ranges in which excitation of nociceptor takes place and for the intensity of excitation when it occurs.

Black mamba venom peptides target acid-sensing ion channels to abolish pain
It is shown that a new class of three-finger peptides from another snake, the black mamba, is able to abolish pain through inhibition of ASICs expressed either in central or peripheral neurons, and these peptides are called mambalgins.

Silencing of the Cav3.2 T‐type calcium channel gene in sensory neurons demonstrates its major role in nociception
The results provide direct evidence linking CaV3.2 T‐type channels to pain perception and suggest that CaV 3.2 may offer a specific molecular target for the treatment of pain.

The effects of total sleep deprivation, selective sleep interruption and sleep recovery on pain tolerance thresholds in healthy subjects
The analgesic effect of SWS recovery is apparently greater than the analgesia induced by level I (World Health Organization) analgesic compounds in mechanical pain experiments in healthy volunteers.

Acid-Sensing Ion Channels in Postoperative Pain
A significant role for peripheral ASIC3-containing channels in postoperative pain is demonstrated and ASIC3 appears to have an important role in deep tissue but also affects prolonged pain evoked by skin incision alone.

A tarantula peptide against pain via ASIC1a channels and opioid mechanisms
The analgesic properties of the peptide are suppressed by antagonists of the μ and δ-opioid receptors and are lost in Penk1−/− mice.
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