Reactome Pathway Database

Schema > Pathway > Entries

Aspirin ADME Show undefined attributes

compartment

created [InstanceEdit:10424722] Weiser, Joel, 2025年08月27日

dbId 10540609

displayName Aspirin ADME

eventOf

[TopLevelPathway:R-SSC-9748784] Drug ADME - Sus scrofa

evidenceType [EvidenceType:9965817] inferred by electronic annotation

goBiologicalProcess [GO_BiologicalProcess:8764] xenobiotic metabolic process

hasDiagram true

hasEHLD false

hasEvent

[Reaction:R-SSC-9645220] SLC16A1:BSG cotransports monocarboxylates, H+ from extracellular region to cytosol - Sus scrofa
[Reaction:R-SSC-9749607] SLCO2B1-1 transports ASA- from extracellular region to cytosol of GI cells - Sus scrofa
[Reaction:R-SSC-9749590] ASA- acetylates ALB - Sus scrofa
[Reaction:R-SSC-9749583] SLC22A7 transports ASA-,ST from extracellular region to cytosol of hepatocytes - Sus scrofa
[Reaction:R-SSC-9749792] CES1,CES2 hydrolyze ASA- to ST - Sus scrofa
[Reaction:R-SSC-9749986] CYP2,3 cytochromes hydroxylate ST to 2,3-DHBA - Sus scrofa
[Reaction:R-SSC-9750016] CYP2,3 cytochromes hydroxylate ST to 2,5-DHBA - Sus scrofa
[Reaction:R-SSC-9749971] ACSM2B-like proteins transform 2,5-DHBA to 2,5-DHB-CoA - Sus scrofa
[Reaction:R-SSC-9750001] GLYAT-like proteins transfer glycine to 2,5-DHB-CoA to form gentisuric acid - Sus scrofa
[Reaction:R-SSC-9750656] ABCC2, ABCC3 transport salicylate metabolites from cytosol to extracellular region of hepatic cells - Sus scrofa
[Reaction:R-SSC-9750666] ALB binds ST - Sus scrofa

inferredFrom

[Pathway:R-HSA-9749641] Aspirin ADME - Homo sapiens

isInDisease false

isInferred true

maxDepth 2

name

Aspirin ADME

releaseDate 2025年09月18日

schemaClass Pathway

species

[Species:49633] Sus scrofa

stId R-SSC-9749641

summation

[Summation:9965816] This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)

[TopLevelPathway:R-SSC-9748784] Drug ADME

(inferredTo)

[Pathway:R-HSA-9749641] Aspirin ADME

(hasEncapsulatedEvent)

[Pathway:R-SSC-2162123] Synthesis of Prostaglandins (PG) and Thromboxanes (TX)

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