Reactome Pathway Database

Schema > Reaction > Entries

Activated FGFR4:p-FRS2 binds GRB2:GAB1:PIK3R1 Show undefined attributes

category binding

compartment

created [InstanceEdit:10424722] Weiser, Joel, 2025年08月27日

dbId 10498247

displayName Activated FGFR4:p-FRS2 binds GRB2:GAB1:PIK3R1

eventOf

[Pathway:R-SSC-5654720] PI-3K cascade:FGFR4 - Sus scrofa

evidenceType [EvidenceType:9965817] inferred by electronic annotation

followingEvent

[Reaction:R-SSC-5654662] Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA - Sus scrofa

inferredFrom

[Reaction:R-HSA-5654659] Activated FGFR4:p-FRS2 binds GRB2:GAB1:PIK3R1 - Homo sapiens

input

isInDisease false

isInferred true

maxDepth 1

name

Activated FGFR4:p-FRS2 binds GRB2:GAB1:PIK3R1

output

[Complex:R-SSC-5654191] Activated FGFR4:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane]

precedingEvent

releaseDate 2025年09月18日

schemaClass Reaction

species

[Species:49633] Sus scrofa

stId R-SSC-5654659

summation

[Summation:9965816] This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)

[Pathway:R-SSC-5654720] PI-3K cascade:FGFR4

(precedingEvent)

[Reaction:R-SSC-5654662] Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA

(inferredTo)

[Reaction:R-HSA-5654659] Activated FGFR4:p-FRS2 binds GRB2:GAB1:PIK3R1

© 2025 Reactome

Cite Us!