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Reaction
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Entries
Activated FGFR4:p-FRS2 binds GRB2:GAB1:PIK3R1
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authored
[InstanceEdit:1489508] Rothfels, K, 2011年08月15日
category
binding
compartment
[Compartment:70101] cytosol
[Compartment:984] extracellular region
[Compartment:876] plasma membrane
created
[InstanceEdit:5654660] Rothfels, Karen, 2014年12月03日
dbId
5654659
deleted
[Deleted:5655543] Deletion of instance: 1268245
displayName
Activated FGFR4:p-FRS2 binds GRB2:GAB1:PIK3R1
eventOf
[Pathway:R-HSA-5654720] PI-3K cascade:FGFR4 - Homo sapiens
followingEvent
[Reaction:R-HSA-5654662] Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA - Homo sapiens
input
[Complex:R-HSA-5654193] Activated FGFR4:p-FRS2 [plasma membrane]
[Complex:R-HSA-179864] GRB2:GAB1:PIK3R1 [cytosol]
isChimeric
false
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:189823] A lipid-anchored Grb2-binding protein that links FGF-receptor activation to the Ras/MAPK signaling pathway
[LiteratureReference:191045] Stimulation of phosphatidylinositol 3-kinase by fibroblast growth factor receptors is mediated by coordinated recruitment of multiple docking proteins
[LiteratureReference:191514] The phosphotyrosine phosphatase SHP2 is a critical mediator of transformation induced by the oncogenic fibroblast growth factor receptor 3
[LiteratureReference:443100] Binding of Shp2 tyrosine phosphatase to FRS2 is essential for fibroblast growth factor-induced PC12 cell differentiation
maxDepth
1
modified
[InstanceEdit:10778922] Weiser, Joel, 2025年08月27日
name
Activated FGFR4:p-FRS2 binds GRB2:GAB1:PIK3R1
orthologousEvent
[Reaction:R-RNO-5654659] Activated FGFR4:p-FRS2 binds GRB2:GAB1:PIK3R1 - Rattus norvegicus
[Reaction:R-DME-5654659] Activated FGFR4:p-FRS2 binds GRB2:GAB1:PIK3R1 - Drosophila melanogaster
[Reaction:R-GGA-5654659] Activated FGFR4:p-FRS2 binds GRB2:GAB1:PIK3R1 - Gallus gallus
[Reaction:R-XTR-5654659] Activated FGFR4:p-FRS2 binds GRB2:GAB1:PIK3R1 - Xenopus tropicalis
[Reaction:R-SSC-5654659] Activated FGFR4:p-FRS2 binds GRB2:GAB1:PIK3R1 - Sus scrofa
[Reaction:R-BTA-5654659] Activated FGFR4:p-FRS2 binds GRB2:GAB1:PIK3R1 - Bos taurus
[Reaction:R-CFA-5654659] Activated FGFR4:p-FRS2 binds GRB2:GAB1:PIK3R1 - Canis familiaris
[Reaction:R-MMU-5654659] Activated FGFR4:p-FRS2 binds GRB2:GAB1:PIK3R1 - Mus musculus
output
[Complex:R-HSA-5654191] Activated FGFR4:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane]
precedingEvent
[Reaction:R-HSA-5654418] Activated FGFR4 phosphorylates FRS2 - Homo sapiens
[Reaction:R-HSA-177931] Binding of PIK3 regulatory alpha subunit to GRB2:GAB1 - Homo sapiens
releaseDate
2011年09月20日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:1549563] Gotoh, N, 2011年08月26日
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-5654659
summation
[Summation:1268244] The direct GRB2-binding sites of FRS2 have a major role in a...
Referrals
(replacementInstances)
[Deleted:5655543] Deletion of instance: 1268245
(normalReaction)
[Reaction:R-HSA-5655248] Activated FGFR4 mutants:p-FRS2 binds GRB2:GAB1:PIK3R1
(hasEvent)
[Pathway:R-HSA-5654720] PI-3K cascade:FGFR4
(precedingEvent)
[Reaction:R-HSA-5654662] Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
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