Reactome Pathway Database

Schema > Reaction > Entries

Phosphorylated SHC recruits GRB2:SOS1 Show undefined attributes

category binding

compartment

created [InstanceEdit:10424722] Weiser, Joel, 2025年08月27日

dbId 10460157

displayName Phosphorylated SHC recruits GRB2:SOS1

eventOf

[Pathway:R-SSC-912526] Interleukin receptor SHC signaling - Sus scrofa

evidenceType [EvidenceType:9965817] inferred by electronic annotation

followingEvent

[Reaction:R-SSC-5672965] RAS GEFs promote RAS nucleotide exchange - Sus scrofa

inferredFrom

[Reaction:R-HSA-453111] Phosphorylated SHC recruits GRB2:SOS1 - Homo sapiens

input

isInDisease false

isInferred true

maxDepth 1

name

Phosphorylated SHC recruits GRB2:SOS1

output

[Complex:R-SSC-921157] Interleukin receptor complexes with activated SHC1:GRB2:SOS1 [plasma membrane]

precedingEvent

releaseDate 2025年09月18日

schemaClass Reaction

species

[Species:49633] Sus scrofa

stId R-SSC-453111

summation

[Summation:9965816] This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)

[Pathway:R-SSC-912526] Interleukin receptor SHC signaling

(precedingEvent)

[Reaction:R-SSC-5672965] RAS GEFs promote RAS nucleotide exchange

(inferredTo)

[Reaction:R-HSA-453111] Phosphorylated SHC recruits GRB2:SOS1

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