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Go!
Schema
>
Complex
>
Entries
GRB2-1:SOS1 [cytosol]
Show undefined attributes
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compartment
[Compartment:70101] cytosol
componentOf
[Complex:R-SSC-5686070] GRB2-1:SOS1:p-3Y-SHC1 [cytosol] - Sus scrofa
[Complex:R-SSC-9032071] BDNF,NTF4:p-5Y-NTRK2:p-Y-FRS2:GRB2-1:SOS1 [plasma membrane] - Sus scrofa
consumedByEvent
[Reaction:R-SSC-5686073] GRB2-1:SOS1 binds p-3Y-SHC1 - Sus scrofa
[Reaction:R-SSC-5685366] GRB2-1:SOS1 binds p-Y-SHC - Sus scrofa
[Reaction:R-SSC-2179415] GRB2:SOS1 binds to HBEGF:p-Y-EGFR - Sus scrofa
[Reaction:R-SSC-1306969] GRB2:SOS1 complex binds phosphorylated ERBB4:ERBB2 heterodimers - Sus scrofa
[Reaction:R-SSC-177943] GRB2:SOS1 complex binds to EGF:EGFR complex - Sus scrofa
[Reaction:R-SSC-1250380] Recruitment of GRB2:SOS1 to phosphorylated SHC1 in complex with phosphorylated ERBB4 homodimers - Sus scrofa
[Reaction:R-SSC-8853734] 2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 binds GRB2-1:SOS1 - Sus scrofa
[Reaction:R-SSC-205286] GRB2:SOS interacts with p-KIT - Sus scrofa
[Reaction:R-SSC-74746] GRB2-1:SOS1 binds p-Y427-SHC1 - Sus scrofa
[Reaction:R-SSC-74736] GRB2-1:SOS1 binds p-IRS1,p-IRS2 - Sus scrofa
[BlackBoxEvent:R-SSC-9032073] NTRK2-phosphorylated FRS2 binds GRB2 - Sus scrofa
[Reaction:R-SSC-8851900] SHC1-2 bound to MET recruits GRB2:SOS1 - Sus scrofa
[Reaction:R-SSC-8851804] Activated MET recruits GRB2-1:SOS1 - Sus scrofa
[Reaction:R-SSC-5654423] Activated FGFR4:p-SHC1 binds GRB2:SOS1 - Sus scrofa
[Reaction:R-SSC-186826] GRB2:SOS1 complex binds to the active receptor - Sus scrofa
[Reaction:R-SSC-177936] GRB2:SOS1 binds to phosphorylated SHC1 in complex with EGFR - Sus scrofa
[Reaction:R-SSC-5654597] Activated FGFR1:p-SHC1 binds GRB2:SOS1 - Sus scrofa
[Reaction:R-SSC-2730844] Interaction of GRB2:SOS complex with p-SHC1 - Sus scrofa
[Reaction:R-SSC-5654664] Activated FGFR4:p-FRS binds GRB2:SOS1 - Sus scrofa
[Reaction:R-SSC-5654586] Activated FGFR1:p-FRS binds GRB2:SOS1 - Sus scrofa
[Reaction:R-SSC-453111] Phosphorylated SHC recruits GRB2:SOS1 - Sus scrofa
[Reaction:R-SSC-453111] Phosphorylated SHC recruits GRB2:SOS1 - Sus scrofa
[Reaction:R-SSC-453111] Phosphorylated SHC recruits GRB2:SOS1 - Sus scrofa
[Reaction:R-SSC-453111] Phosphorylated SHC recruits GRB2:SOS1 - Sus scrofa
[Reaction:R-SSC-8854899] 2x p-5Y-RET:GDNF:GFRA complexes bind GRB2-1:SOS1 - Sus scrofa
created
[InstanceEdit:10424722] Weiser, Joel, 2025年08月27日
dbId
10429895
displayName
GRB2-1:SOS1 [cytosol]
hasComponent
[EntityWithAccessionedSequence:R-SSC-74686] GRB2 [cytosol]
[EntityWithAccessionedSequence:R-SSC-64847] SOS1 [cytosol]
inDisease
false
inferredFrom
[Complex:R-HSA-109797] GRB2-1:SOS1 [cytosol] - Homo sapiens
maxDepth
2
name
GRB2-1:SOS1
producedByEvent
[Reaction:R-SSC-109813] GRB2-1 binds SOS1 - Sus scrofa
schemaClass
Complex
species
[Species:49633] Sus scrofa
stId
R-SSC-109797
summation
[Summation:9965818] This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.
Referrals
(hasComponent)
[Complex:R-SSC-9032071] BDNF,NTF4:p-5Y-NTRK2:p-Y-FRS2:GRB2-1:SOS1 [plasma membrane]
[Complex:R-SSC-5686070] GRB2-1:SOS1:p-3Y-SHC1 [cytosol]
[Complex:R-SSC-186827] PDGF:Phospho-PDGF receptor dimer:Grb2:Sos1 [plasma membrane]
[Complex:R-SSC-921157] Interleukin receptor complexes with activated SHC1:GRB2:SOS1 [plasma membrane]
[Complex:R-SSC-5654296] Activated FGFR2:pY-SHC1:GRB2:SOS1 [plasma membrane]
[Complex:R-SSC-1306947] NRGs/EGFLs:p-ERBB4:p-ERBB2:GRB2:SOS1 [plasma membrane]
[Complex:R-SSC-5654343] Activated FGFR4:pY-SHC1:GRB2:SOS1 [plasma membrane]
[Complex:R-SSC-205202] GRB2:SOS1:p-KIT complex [plasma membrane]
[Complex:R-SSC-5654275] Activated FGFR1:p-SHC1:GRB2:SOS1 [plasma membrane]
[Complex:R-SSC-8851807] HGF:p-4Y-MET dimer:GRB2-1:SOS1 [plasma membrane]
[Complex:R-SSC-5654287] Activated FGFR2:p-FRS:GRB2:SOS1 [plasma membrane]
[Complex:R-SSC-1250505] EGF:p-EGFR:p-ERBB2:GRB2:SOS1 [plasma membrane]
[Complex:R-SSC-1250382] GRB2:SOS1:p-Y349,350-SHC1:p-ERBB4 [plasma membrane]
[Complex:R-SSC-5654327] Activated FGFR4:p-FRS2:GRB2:SOS1 [plasma membrane]
[Complex:R-SSC-5685367] GRB2-1:SOS1:p-Y-SHC [cytosol]
[Complex:R-SSC-109798] GRB2-1:SOS1:p-Y427-SHC1 [cytosol]
[Complex:R-SSC-109800] GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2 [cytosol]
[Complex:R-SSC-180331] EGF-like ligands:p-6Y-EGFR:p-Y349,350-SHC1:GRB2:SOS1 [plasma membrane]
[Complex:R-SSC-5654264] Activated FGFR1:p-FRS2:GRB2:SOS1 [plasma membrane]
[Complex:R-SSC-179820] EGF-like ligands:p-6Y-EGFR:GRB2:SOS1 [plasma membrane]
[Complex:R-SSC-2685672] p-SHC1:GRB2:SOS [cytosol]
[Complex:R-SSC-2179409] GRB2:SOS1:HB-EGF:p-6Y-EGFR [plasma membrane]
[Complex:R-SSC-8854903] 2x p-5Y-RET:GDNF:GFRA complexes:GRB2-1:SOS1 [plasma membrane]
[Complex:R-SSC-5654308] Activated FGFR3:p-FRS:GRB2:SOS1 [plasma membrane]
[Complex:R-SSC-8854399] 2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1:GRB2-1:SOS1 [plasma membrane]
[Complex:R-SSC-5654316] Activated FGFR3:pY-SHC1:GRB2:SOS1 [plasma membrane]
[Complex:R-SSC-1250479] GRB2:SOS1:p-Y349,350-SHC1:Phosphorylated ERBB2 heterodimers [plasma membrane]
[Complex:R-SSC-8851897] HGF:p-4Y-MET dimer:p-Y317-SHC1-2:GRB2:SOS1 [plasma membrane]
(input)
[BlackBoxEvent:R-SSC-9032073] NTRK2-phosphorylated FRS2 binds GRB2
[Reaction:R-SSC-5686073] GRB2-1:SOS1 binds p-3Y-SHC1
[Reaction:R-SSC-5685366] GRB2-1:SOS1 binds p-Y-SHC
[Reaction:R-SSC-8851900] SHC1-2 bound to MET recruits GRB2:SOS1
[Reaction:R-SSC-2179415] GRB2:SOS1 binds to HBEGF:p-Y-EGFR
[Reaction:R-SSC-8851804] Activated MET recruits GRB2-1:SOS1
[Reaction:R-SSC-5654423] Activated FGFR4:p-SHC1 binds GRB2:SOS1
[Reaction:R-SSC-186826] GRB2:SOS1 complex binds to the active receptor
[Reaction:R-SSC-1306969] GRB2:SOS1 complex binds phosphorylated ERBB4:ERBB2 heterodimers
[Reaction:R-SSC-177936] GRB2:SOS1 binds to phosphorylated SHC1 in complex with EGFR
[Reaction:R-SSC-5654597] Activated FGFR1:p-SHC1 binds GRB2:SOS1
[Reaction:R-SSC-2730844] Interaction of GRB2:SOS complex with p-SHC1
[Reaction:R-SSC-177943] GRB2:SOS1 complex binds to EGF:EGFR complex
[Reaction:R-SSC-1250380] Recruitment of GRB2:SOS1 to phosphorylated SHC1 in complex with phosphorylated ERBB4 homodimers
[Reaction:R-SSC-5654664] Activated FGFR4:p-FRS binds GRB2:SOS1
[Reaction:R-SSC-8853734] 2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 binds GRB2-1:SOS1
[Reaction:R-SSC-205286] GRB2:SOS interacts with p-KIT
[Reaction:R-SSC-5654586] Activated FGFR1:p-FRS binds GRB2:SOS1
[Reaction:R-SSC-74746] GRB2-1:SOS1 binds p-Y427-SHC1
[Reaction:R-SSC-74736] GRB2-1:SOS1 binds p-IRS1,p-IRS2
[Reaction:R-SSC-453111] Phosphorylated SHC recruits GRB2:SOS1
[Reaction:R-SSC-8854899] 2x p-5Y-RET:GDNF:GFRA complexes bind GRB2-1:SOS1
(output)
[Reaction:R-SSC-109813] GRB2-1 binds SOS1
(inferredTo)
[Complex:R-HSA-109797] GRB2-1:SOS1 [cytosol]
(activeUnit)
[CatalystActivity:10515687] guanyl-nucleotide exchange factor activity of HGF:p-4Y-MET dimer:GRB2-1:SOS1 [plasma membrane]
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