Reactome Pathway Database

Schema > Reaction > Entries

SLC6A4 co-transports 5HT, Cl-, Na+ from extracellular region to cytosol Show undefined attributes

catalystActivity

[CatalystActivity:10458087] serotonin:sodium:chloride symporter activity of SLC6A4 [plasma membrane]

category transition

compartment

created [InstanceEdit:10424722] Weiser, Joel, 2025年08月27日

dbId 10458089

displayName SLC6A4 co-transports 5HT, Cl-, Na+ from extracellular region to cytosol

eventOf

[Pathway:R-SSC-380615] Serotonin clearance from the synaptic cleft - Sus scrofa

evidenceType [EvidenceType:9965817] inferred by electronic annotation

followingEvent

[Reaction:R-SSC-141186] MAOA:FAD oxidatively deaminates of 5HT - Sus scrofa

goBiologicalProcess [GO_BiologicalProcess:172102] serotonin uptake

inferredFrom

[Reaction:R-HSA-444008] SLC6A4 co-transports 5HT, Cl-, Na+ from extracellular region to cytosol - Homo sapiens

input

isInDisease false

isInferred true

maxDepth 1

name

SLC6A4 co-transports 5HT, Cl-, Na+ from extracellular region to cytosol
SERT mediates serotonin uptake

output

releaseDate 2025年09月18日

schemaClass Reaction

species

[Species:49633] Sus scrofa

stId R-SSC-444008

summation

[Summation:9965816] This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)

[Pathway:R-SSC-380615] Serotonin clearance from the synaptic cleft

(precedingEvent)

[Reaction:R-SSC-141186] MAOA:FAD oxidatively deaminates of 5HT

(inferredTo)

[Reaction:R-HSA-444008] SLC6A4 co-transports 5HT, Cl-, Na+ from extracellular region to cytosol

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