Reactome Pathway Database

Schema > Reaction > Entries

UROS transforms HMB to URO3 Show undefined attributes

catalystActivity

[CatalystActivity:10441047] uroporphyrinogen-III synthase activity of UROS [cytosol]

category transition

compartment

[Compartment:70101] cytosol

created [InstanceEdit:10424722] Weiser, Joel, 2025年08月27日

dbId 10441049

displayName UROS transforms HMB to URO3

eventOf

[Pathway:R-SSC-189451] Heme biosynthesis - Sus scrofa

evidenceType [EvidenceType:9965817] inferred by electronic annotation

followingEvent

[Reaction:R-SSC-189425] UROD decarboxylates URO3 to COPRO3 - Sus scrofa

inferredFrom

[Reaction:R-HSA-189488] UROS transforms HMB to URO3 - Homo sapiens

input

[SimpleEntity:R-ALL-189449] HMBL [cytosol]

isInDisease false

isInferred true

maxDepth 1

name

UROS transforms HMB to URO3
hydroxymethylbilane => H2O + uroporphyrinogen III
Conversion of HMB to uroporphyrinogen III

output

precedingEvent

[Reaction:R-SSC-189406] 4 PBGs bind to form HMB - Sus scrofa

releaseDate 2025年09月18日

schemaClass Reaction

species

[Species:49633] Sus scrofa

stId R-SSC-189488

summation

[Summation:9965816] This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)

[Pathway:R-SSC-189451] Heme biosynthesis

(precedingEvent)

[Reaction:R-SSC-189425] UROD decarboxylates URO3 to COPRO3

(inferredTo)

[Reaction:R-HSA-189488] UROS transforms HMB to URO3

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