Reactome Pathway Database

Schema > Reaction > Entries

4 PBGs bind to form HMB Show undefined attributes

catalystActivity

[CatalystActivity:10440973] hydroxymethylbilane synthase activity of HMBS:DIPY [cytosol]

category transition

compartment

[Compartment:70101] cytosol

created [InstanceEdit:10424722] Weiser, Joel, 2025年08月27日

dbId 10440975

displayName 4 PBGs bind to form HMB

eventOf

[Pathway:R-SSC-189451] Heme biosynthesis - Sus scrofa

evidenceType [EvidenceType:9965817] inferred by electronic annotation

followingEvent

[Reaction:R-SSC-189488] UROS transforms HMB to URO3 - Sus scrofa

inferredFrom

[Reaction:R-HSA-189406] 4 PBGs bind to form HMB - Homo sapiens

input

isInDisease false

isInferred true

maxDepth 1

name

4 PBGs bind to form HMB
H2O + 4 porphobilinogen => hydroxymethylbilane + 4 NH4(+)
Four PBGs combine through deamination to form hydroxymethylbilane (HMB)

output

precedingEvent

[Reaction:R-SSC-189439] ALAD condenses 2 dALAs to form PBG - Sus scrofa

releaseDate 2025年09月18日

schemaClass Reaction

species

[Species:49633] Sus scrofa

stId R-SSC-189406

summation

[Summation:9965816] This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)

[Pathway:R-SSC-189451] Heme biosynthesis

(precedingEvent)

[Reaction:R-SSC-189488] UROS transforms HMB to URO3

(inferredTo)

[Reaction:R-HSA-189406] 4 PBGs bind to form HMB

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