Reactome Pathway Database

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The Ligand:GPCR:Gz complex dissociates Show undefined attributes

category dissociation

compartment

created [InstanceEdit:9965813] Weiser, Joel, 2025年08月27日

dbId 10001849

displayName The Ligand:GPCR:Gz complex dissociates

eventOf

[Pathway:R-MMU-418597] G alpha (z) signalling events - Mus musculus

evidenceType [EvidenceType:9965817] inferred by electronic annotation

followingEvent

[Reaction:R-MMU-8981892] Active G alpha (z) binds RGS proteins - Mus musculus
[Reaction:R-MMU-392064] G alpha (z) inhibits adenylate cyclase - Mus musculus
[Reaction:R-MMU-8964241] G beta-gamma complex and PIP3 recruit BTK to membrane - Mus musculus
[Reaction:R-MMU-398040] Gbeta:gamma activation of PLC beta - Mus musculus
[Reaction:R-MMU-8964605] PAK1:ARHGEF6 complex binds G-protein beta-gamma complex - Mus musculus
[Reaction:R-MMU-392295] Gbeta:gamma recruits PI3K gamma - Mus musculus

inferredFrom

[Reaction:R-HSA-751024] The Ligand:GPCR:Gz complex dissociates - Homo sapiens

input

[Complex:R-MMU-751030] ADRA2A-C:Catecholamine:Heterotrimeric G-protein Gz (active) [plasma membrane]

isInDisease false

isInferred true

maxDepth 1

name

The Ligand:GPCR:Gz complex dissociates

output

precedingEvent

[Reaction:R-MMU-749453] Liganded Gz-activating GPCR acts as a GEF for Gz - Mus musculus

releaseDate 2025年09月18日

schemaClass Reaction

species

[Species:48892] Mus musculus

stId R-MMU-751024

summation

[Summation:9965816] This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)

[Pathway:R-MMU-418597] G alpha (z) signalling events

(precedingEvent)

(inferredTo)

[Reaction:R-HSA-751024] The Ligand:GPCR:Gz complex dissociates

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