Reactome Pathway Database

Schema > Reaction > Entries

histidine => urocanate + NH4+ Show undefined attributes

catalystActivity

[CatalystActivity:9967645] histidine ammonia-lyase activity of HAL [cytosol]

category transition

compartment

[Compartment:70101] cytosol

created [InstanceEdit:9965813] Weiser, Joel, 2025年08月27日

dbId 9967647

displayName histidine => urocanate + NH4+

eventOf

[Pathway:R-MMU-70921] Histidine catabolism - Mus musculus

evidenceType [EvidenceType:9965817] inferred by electronic annotation

followingEvent

[Reaction:R-MMU-70903] urocanate + H2O => 4-imidazolone-5-propanoate - Mus musculus

inferredFrom

[Reaction:R-HSA-70899] histidine => urocanate + NH4+ - Homo sapiens

input

[SimpleEntity:R-ALL-29612] L-His [cytosol]

isInDisease false

isInferred true

maxDepth 1

name

histidine => urocanate + NH4+
L-histidine => NH4(+) + trans-urocanate

output

precedingEvent

[Reaction:R-MMU-8932851] PQLC2 transports L-Arg,L-His,L-Lys from lysosomal lumen to cytosol - Mus musculus

releaseDate 2025年09月18日

schemaClass Reaction

species

[Species:48892] Mus musculus

stId R-MMU-70899

summation

[Summation:9965816] This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)

[Pathway:R-MMU-70921] Histidine catabolism

(precedingEvent)

[Reaction:R-MMU-70903] urocanate + H2O => 4-imidazolone-5-propanoate

(inferredTo)

[Reaction:R-HSA-70899] histidine => urocanate + NH4+

© 2025 Reactome

Cite Us!