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Schema
>
Reaction
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Entries
ALK binds ALKAL ligand
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authored
[InstanceEdit:9851210] Rothfels, Karen, 2023年10月14日
category
binding
compartment
[Compartment:876] plasma membrane
[Compartment:984] extracellular region
created
[InstanceEdit:9842653] Rothfels, Karen, 2023年08月27日
dbId
9842656
displayName
ALK binds ALKAL ligand
edited
[InstanceEdit:9851215] Rothfels, Karen, 2023年10月14日
eventOf
[Pathway:R-HSA-201556] Signaling by ALK - Homo sapiens
followingEvent
[Reaction:R-HSA-9700662] Liganded-ALK dimer binds type I ALK-binding TKIs - Homo sapiens
[Reaction:R-HSA-201521] ALK autophosphorylation - Homo sapiens
input
2 ×
[EntityWithAccessionedSequence:R-HSA-201502] ALK [plasma membrane]
[CandidateSet:R-HSA-9842597] ALKAL2:(ALKAL1) [extracellular region]
isChimeric
false
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:9842437] Deorphanization of the human leukocyte tyrosine kinase (LTK) receptor by a signaling screen of the extracellular proteome
[LiteratureReference:9842539] FAM150A and FAM150B are activating ligands for anaplastic lymphoma kinase
[LiteratureReference:9842433] Augmentor ? and ? (FAM150) are ligands of the receptor tyrosine kinases ALK and LTK: Hierarchy and specificity of ligand-receptor interactions
[LiteratureReference:9842490] Identification of a biologically active fragment of ALK and LTK-Ligand 2 (augmentor-?)
[LiteratureReference:9842445] Mechanism for the activation of the anaplastic lymphoma kinase receptor
[LiteratureReference:9842419] Structural basis of cytokine-mediated activation of ALK family receptors
maxDepth
1
modified
[InstanceEdit:10680101] Weiser, Joel, 2025年08月27日
name
ALK binds ALKAL ligand
orthologousEvent
[Reaction:R-GGA-9842656] ALK binds ALKAL ligand - Gallus gallus
[Reaction:R-DRE-9842656] ALK binds ALKAL ligand - Danio rerio
[Reaction:R-SSC-9842656] ALK binds ALKAL ligand - Sus scrofa
[Reaction:R-BTA-9842656] ALK binds ALKAL ligand - Bos taurus
[Reaction:R-CFA-9842656] ALK binds ALKAL ligand - Canis familiaris
[Reaction:R-RNO-9842656] ALK binds ALKAL ligand - Rattus norvegicus
[Reaction:R-MMU-9842656] ALK binds ALKAL ligand - Mus musculus
output
[Complex:R-HSA-9842608] ALK dimer:ALKAL2:(ALKAL1) [plasma membrane]
releaseDate
2023年12月06日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:9852935] Turner, Suzanne, 2023年11月08日
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-9842656
summation
[Summation:9842664] Signaling through the ALK receptor is activated by the bindi...
Referrals
(normalReaction)
[Reaction:R-HSA-9700184] Ligand-independent dimerization of point mutants of ALK
[Reaction:R-HSA-9700179] Ligand-independent dimerization of ALK fusions
(hasEvent)
[Pathway:R-HSA-201556] Signaling by ALK
(precedingEvent)
[Reaction:R-HSA-9700662] Liganded-ALK dimer binds type I ALK-binding TKIs
[Reaction:R-HSA-201521] ALK autophosphorylation
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