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Entries
Ligand-independent dimerization of point mutants of ALK
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authored
[InstanceEdit:9724129] Rothfels, Karen, 2021年03月22日
category
transition
compartment
[Compartment:876] plasma membrane
created
[InstanceEdit:9700185] Rothfels, Karen, 2020年09月14日
crossReference
[DatabaseIdentifier:11944892] Mondo:0004992
dbId
9700184
disease
[Disease:1500689] cancer
displayName
Ligand-independent dimerization of point mutants of ALK
edited
[InstanceEdit:9725664] Rothfels, Karen, 2021年03月30日
eventOf
[Pathway:R-HSA-9725370] Signaling by ALK fusions and activated point mutants - Homo sapiens
followingEvent
[Reaction:R-HSA-9700186] Autophosphorylation of point mutants of ALK - Homo sapiens
input
2 ×
[DefinedSet:R-HSA-9700567] ALK point mutants [plasma membrane]
isChimeric
false
isInDisease
true
isInferred
false
literatureReference
[LiteratureReference:9699633] Anaplastic lymphoma kinase (ALK): structure, oncogenic activation, and pharmacological inhibition
[LiteratureReference:9667872] Mechanistic insight into ALK receptor tyrosine kinase in human cancer biology
[LiteratureReference:9718441] The role of the ALK receptor in cancer biology
[LiteratureReference:9699768] Role and targeting of anaplastic lymphoma kinase in cancer
[LiteratureReference:9701722] Identification of ALK as a major familial neuroblastoma predisposition gene
[LiteratureReference:9723288] Cell culture and Drosophila model systems define three classes of anaplastic lymphoma kinase mutations in neuroblastoma
[LiteratureReference:9723817] Activating ALK mutations found in neuroblastoma are inhibited by Crizotinib and NVP-TAE684
[LiteratureReference:9700412] Activating mutations in ALK provide a therapeutic target in neuroblastoma
[LiteratureReference:9723851] Somatic and germline activating mutations of the ALK kinase receptor in neuroblastoma
[LiteratureReference:9700372] Oncogenic mutations of ALK kinase in neuroblastoma
[LiteratureReference:9701769] Anaplastic thyroid cancers harbor novel oncogenic mutations of the ALK gene
[LiteratureReference:9715255] Identification of oncogenic point mutations and hyperphosphorylation of anaplastic lymphoma kinase in lung cancer
[LiteratureReference:9700339] Crizotinib-resistant NPM-ALK mutants confer differential sensitivity to unrelated Alk inhibitors
[LiteratureReference:9700357] Treatment Efficacy and Resistance Mechanisms Using the Second-Generation ALK Inhibitor AP26113 in Human NPM-ALK-Positive Anaplastic Large Cell Lymphoma
maxDepth
1
modified
[InstanceEdit:9851215] Rothfels, Karen, 2023年10月14日
name
Ligand-independent dimerization of point mutants of ALK
normalReaction
[Reaction:R-HSA-9842656] ALK binds ALKAL ligand
output
[DefinedSet:R-HSA-9700436] ALK point mutant dimers [plasma membrane]
releaseDate
2021年06月09日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:9729891] Inghirami, Giorgio, 2021年05月04日
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-9700184
summation
[Summation:9723306] In addition to activation by translocations that lead to the...
updateTrackers
[UpdateTracker:9853260] Update Tracker - [Reaction:9700184] Ligand-independent dimerization of point mutants of ALK - v87:[modifyText]
Referrals
(updatedInstance)
[UpdateTracker:9853260] Update Tracker - [Reaction:9700184] Ligand-independent dimerization of point mutants of ALK - v87:[modifyText]
(hasEvent)
[Pathway:R-HSA-9725370] Signaling by ALK fusions and activated point mutants
(precedingEvent)
[Reaction:R-HSA-9700186] Autophosphorylation of point mutants of ALK
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