Reactome Pathway Database

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SARS-CoV-2 3a induces potassium efflux Show undefined attributes

authored

[InstanceEdit:9730519] Stephan, Ralf, 2021年05月07日

catalystActivity

[CatalystActivity:9730517] inward rectifier potassium channel activity of O-glycosyl 3a tetramer [plasma membrane]

category transition

compartment

created [InstanceEdit:9730519] Stephan, Ralf, 2021年05月07日

crossReference

dbId 9730521

disease

[Disease:9683912] COVID-19

displayName SARS-CoV-2 3a induces potassium efflux

edited

[InstanceEdit:9766200] Shamovsky, Veronica, 2022年02月18日

eventOf

[Pathway:R-HSA-9705671] SARS-CoV-2 activates/modulates innate and adaptive immune responses - Homo sapiens

input

[SimpleEntity:R-ALL-29804] K+ [cytosol]

isChimeric false

isInDisease true

isInferred false

literatureReference

[LiteratureReference:9730532] SARS-CoV-2 viroporin encoded by ORF3a triggers the NLRP3 inflammatory pathway

maxDepth 1

modified [InstanceEdit:9830342] Matthews, Lisa, 2023年03月08日

name

SARS-CoV-2 3a induces potassium efflux

output

[SimpleEntity:R-ALL-74126] K+ [extracellular region]

precedingEvent

[BlackBoxEvent:R-HSA-9694572] 3a localizes to the cell membrane - Homo sapiens

relatedSpecies

[Species:9681683] Severe acute respiratory syndrome coronavirus 2

releaseDate 2022年03月23日

reviewStatus [ReviewStatus:9821382] five stars

reviewed

[InstanceEdit:9766195] Messina, Francesco, 2022年02月18日

schemaClass Reaction

species

[Species:48887] Homo sapiens

stId R-HSA-9730521

summation

[Summation:9730507] SARS-CoV-2 viroporin 3a (ORF3a) is a membrane protein that t...

Referrals

(hasEvent)

[Pathway:R-HSA-9705671] SARS-CoV-2 activates/modulates innate and adaptive immune responses

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