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SARS-CoV-2 nsp3 cleaves IRF3 Show undefined attributes

authored

[InstanceEdit:9733900] Stephan, Ralf, 2021年06月11日

catalystActivity

[CatalystActivity:9729726] cysteine-type endopeptidase activity of N-glycan nsp3 [endoplasmic reticulum membrane]

category transition

compartment

[Compartment:70101] cytosol

created [InstanceEdit:9729750] Stephan, Ralf, 2021年05月03日

crossReference

[DatabaseIdentifier:11944893] Mondo:0100096

dbId 9729730

disease

[Disease:9683912] COVID-19

displayName SARS-CoV-2 nsp3 cleaves IRF3

edited

[InstanceEdit:9766200] Shamovsky, Veronica, 2022年02月18日

eventOf

[Pathway:R-HSA-9705671] SARS-CoV-2 activates/modulates innate and adaptive immune responses - Homo sapiens

input

isChimeric false

isInDisease true

isInferred false

literatureReference

[LiteratureReference:9729719] SARS-CoV-2 proteases PLpro and 3CLpro cleave IRF3 and critical modulators of inflammatory pathways (NLRP12 and TAB1): implications for disease presentation across species

maxDepth 1

modified [InstanceEdit:9830342] Matthews, Lisa, 2023年03月08日

name

SARS-CoV-2 nsp3 cleaves IRF3

output

precedingEvent

relatedSpecies

[Species:9681683] Severe acute respiratory syndrome coronavirus 2

releaseDate 2022年03月23日

reviewStatus [ReviewStatus:9821382] five stars

reviewed

[InstanceEdit:9766195] Messina, Francesco, 2022年02月18日

schemaClass Reaction

species

[Species:48887] Homo sapiens

stId R-HSA-9729730

summation

[Summation:9729722] SARS-CoV-2 nsp3 protease (PLpro) specifically cleaves IRF3 a...

Referrals

(hasEvent)

[Pathway:R-HSA-9705671] SARS-CoV-2 activates/modulates innate and adaptive immune responses

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