Reactome | O-glycosylation of 3a is terminated

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O-glycosylation of 3a is terminated Show undefined attributes

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authored

[InstanceEdit:9698836] Stephan, Ralf, 2020年08月28日

catalystActivity

[CatalystActivity:9683749] sialyltransferase activity of sialyltransferases

category transition

compartment

[Compartment:190626] endoplasmic reticulum-Golgi intermediate compartment

created [InstanceEdit:9694660] Cook, Justin, 2020年07月07日

crossReference

[DatabaseIdentifier:11944893] Mondo:0100096

dbId 9694718

disease

[Disease:9683912] COVID-19

displayName O-glycosylation of 3a is terminated

edited

[InstanceEdit:9698836] Stephan, Ralf, 2020年08月28日

eventOf

[Pathway:R-HSA-9694719] Maturation of protein 3a - Homo sapiens

followingEvent

inferredFrom

[Reaction:R-HSA-9683769] O-glycosylation of 3a is terminated - Homo sapiens

input

isChimeric false

isInDisease true

isInferred true

literatureReference

[LiteratureReference:9682859] Glycosylation of the severe acute respiratory syndrome coronavirus triple-spanning membrane proteins 3a and M

maxDepth 1

modified [InstanceEdit:9830342] Matthews, Lisa, 2023年03月08日

name

O-glycosylation of 3a is terminated

output

precedingEvent

[Reaction:R-HSA-9694438] GalNAc is transferred onto 3a - Homo sapiens

relatedSpecies

[Species:9681683] Severe acute respiratory syndrome coronavirus 2

releaseDate 2020年09月15日

reviewStatus [ReviewStatus:9821382] five stars

reviewed

[InstanceEdit:9699044] Acencio, Marcio Luis, 2020年09月09日

schemaClass Reaction

species

[Species:48887] Homo sapiens

stId R-HSA-9694718

summation

[Summation:9694722] This COVID-19 event has been created by a combination of computational inference (see https://reactome.org/documentation/inferred-events) from SARS-CoV-1 data and manual curation, as described in the summation for the overall SARS-CoV-2 infection pathway.

A sialyltransferase adds a terminal sialic acid moiety to protein 3a with an O-linked glycosyl side chain. This glycosylated form later is associated with the virion (Oostra et al, 2006)

Referrals

(hasEvent)

[Pathway:R-HSA-9694719] Maturation of protein 3a

(precedingEvent)

(inferredTo)

[Reaction:R-HSA-9683769] O-glycosylation of 3a is terminated

Reactome Pathway Database

Reactome Pathway Database

O-glycosylation of 3a is terminated Show undefined attributes

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