Reactome | Fusion and Release of SARS-CoV-2 Nucleocapsid

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Fusion and Release of SARS-CoV-2 Nucleocapsid Show undefined attributes

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authored

[InstanceEdit:9699040] Gillespie, Marc E, 2020年09月09日

category dissociation

compartment

[Compartment:24337] endocytic vesicle membrane

created [InstanceEdit:9694660] Cook, Justin, 2020年07月07日

crossReference

[DatabaseIdentifier:11944893] Mondo:0100096

dbId 9694689

disease

[Disease:9683912] COVID-19

displayName Fusion and Release of SARS-CoV-2 Nucleocapsid

edited

[InstanceEdit:9699040] Gillespie, Marc E, 2020年09月09日

eventOf

[Pathway:R-HSA-9694614] Attachment and Entry - Homo sapiens

followingEvent

[Reaction:R-HSA-9694723] Uncoating of SARS-CoV-2 Genome - Homo sapiens

inferredFrom

[Reaction:R-HSA-9686699] Fusion and Release of SARS-CoV-1 Nucleocapsid - Homo sapiens

input

[Complex:R-COV-9694585] S1:S2:M:E:encapsidated SARS-CoV-2 genomic RNA: 7a:O-glycosyl 3a tetramer [endocytic vesicle lumen]

isChimeric false

isInDisease true

isInferred true

literatureReference

[LiteratureReference:9687536] Genome-Wide Screen Reveals Valosin-Containing Protein Requirement for Coronavirus Exit from Endosomes

maxDepth 1

modified [InstanceEdit:9830342] Matthews, Lisa, 2023年03月08日

name

Fusion and Release of SARS-CoV-2 Nucleocapsid

output

precedingEvent

regulatedBy

[PositiveRegulation:9687542] Positive regulation by 'VCP [cytosol]'

relatedSpecies

[Species:9681683] Severe acute respiratory syndrome coronavirus 2

releaseDate 2020年09月15日

reviewStatus [ReviewStatus:9821382] five stars

reviewed

[InstanceEdit:9699044] Acencio, Marcio Luis, 2020年09月09日

schemaClass Reaction

species

[Species:48887] Homo sapiens

stId R-HSA-9694689

summation

[Summation:9694578] This COVID-19 event has been created by a combination of computational inference (see https://reactome.org/documentation/inferred-events) from SARS-CoV-1 data and manual curation, as described in the summation for the overall SARS-CoV-2 infection pathway.

The SARS-CoV-2 nucleocapsid is released from the host cell endosome into the cytosol. Molecular details of this step are not well worked out. Studies of the infection of the human cultured cells with HCoV-229E coronavirus established a requirement for VCP (transitional endoplasmic reticulum ATPase) protein function for release to occur (Wong et al. 2015). A similar requirement for VCP involvement in SARS-CoV-2 nucleocapsid release is inferred here.

Referrals

(hasEvent)

[Pathway:R-HSA-9694614] Attachment and Entry

(precedingEvent)

[Reaction:R-HSA-9694723] Uncoating of SARS-CoV-2 Genome

(inferredTo)

[Reaction:R-HSA-9686699] Fusion and Release of SARS-CoV-1 Nucleocapsid

Reactome Pathway Database

Reactome Pathway Database

Fusion and Release of SARS-CoV-2 Nucleocapsid Show undefined attributes

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