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nsp14 acts as a 3'-to-5' exonuclease to remove misincorporated nucleotides from nascent RNA Show undefined attributes

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authored

[InstanceEdit:9697308] Orlic-Milacic, Marija, 2020年08月12日

catalystActivity

[CatalystActivity:9694426] 3'-5'-RNA exonuclease activity of SARS coronavirus gRNA:RTC:nascent RNA minus strand with mismatched nucleotide [double membrane vesicle viral factory outer membrane]

category transition

compartment

created [InstanceEdit:9694660] Cook, Justin, 2020年07月07日

crossReference

[DatabaseIdentifier:11944893] Mondo:0100096

dbId 9694632

disease

[Disease:9683912] COVID-19

displayName nsp14 acts as a 3'-to-5' exonuclease to remove misincorporated nucleotides from nascent RNA

edited

[InstanceEdit:9697657] Orlic-Milacic, Marija, 2020年08月18日

eventOf

[Pathway:R-HSA-9694686] Replication of the SARS-CoV-2 genome - Homo sapiens

followingEvent

input

isChimeric false

isInDisease true

isInferred false

literatureReference

maxDepth 1

modified [InstanceEdit:9830342] Matthews, Lisa, 2023年03月08日

name

nsp14 acts as a 3'-to-5' exonuclease to remove misincorporated nucleotides from nascent RNA

output

precedingEvent

[Reaction:R-HSA-9815529] nsp12 transfers guanylyl onto SARS-CoV-2 plus strand subgenomic RNAs - Homo sapiens

relatedSpecies

[Species:9681683] Severe acute respiratory syndrome coronavirus 2

releaseDate 2020年09月15日

reviewStatus [ReviewStatus:9821382] five stars

reviewed

[InstanceEdit:9699044] Acencio, Marcio Luis, 2020年09月09日

schemaClass Reaction

species

[Species:48887] Homo sapiens

stId R-HSA-9694632

summation

[Summation:9694564] In human SARS coronavirus 2 (SARS-CoV-2) nsp14 is essential ...

updateTrackers

Referrals

(updatedInstance)

(hasEvent)

[Pathway:R-HSA-9694686] Replication of the SARS-CoV-2 genome

(precedingEvent)

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